Relationship between power Doppler grade and the pathological blood vessel features in long-standing rheumatoid arthritis

Saito, Katsumi; Abe, Asami; Kamishima, Tamotsu; Ishikawa, Hajime; Wakaki, Kunihiko; Ishizu, Akihiro

doi:10.1007/s00296-016-3576-2

Cited by 1 publication

(2 citation statements)

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“…This suggests that dilated vessels but not all vessels contribute to the substantial blood flow. Similar relationship between PD values and synovial vessels in longstanding RA patients has been reported (Schmidt et al 2000;Saito et al 2016).…”

Section: Discussionsupporting

confidence: 83%

“…Those findings contribute to estimate disease severity (Newman et al 1994(Newman et al , 1996. PD values have been shown to represent the blood vessel area in synovial tissues (Saito et al 2016) and well reflect response to treatment (Fukae et al 2014;Hau et al 2002Hau et al , 1999Ribbens et al 2003), prognosis (Ellegaard et al 2011;Koch. 1998;Salaffi et al 2010;Scirè et al 2009), and bone destruction (Brown et al 2008;Fukae et al 2014;Ikeda et al 2013;Peluso et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Detection of Increased Vascular Signal in Arthritis-Prone Rats Without Joint Swelling Using Superb Microvascular Imaging Ultrasonography

Horie

Nishida

Tanimura

et al. 2019

Ultrasound in Medicine & Biology

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This study aimed to determine whether ultrasonography (US) can detect increased vascular signal in the synovial tissue prior to overt synovitis in rheumatoid arthritis (RA). Env-pX rats that spontaneously develop RA-like synovitis were used. Ankle joints of 15 pre-morbid env-pX rats were observed with power Doppler and superb microvascular imaging (SMI) using an ultrahighfrequency (8-24 MHz) probe. Signal values were counted as the number of pixels. The total number of vessels and vessel area in the synovial tissue were histologically evaluated. Dilated vessels were determined from the mean value of synovial vessels in three wild-type rats. In all env-pX rats, apparent synovial proliferation was not observed. However, vasodilation was evident. Only SMI values were significantly correlated with the number of dilated vessels (r=0.585, p=0.022) but not with the total number of vessels. US with SMI using ultrahighfrequency probe can detect increased vascular signal in the synovial tissue of arthritis-prone rats.

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Section: Discussionsupporting

confidence: 83%