Relationship between Postural Stability, Lead Content, and Selected Parameters of Oxidative Stress

Wąsik, Marta; Miśkiewicz-Orczyk, Katarzyna; Słota, Michał; Lisowska, Grażyna; Kasperczyk, Aleksandra; Bellanti, Francesco; Dobrakowski, Michał; Błaszczyk, Urszula; Bułdak, Rafał Jakub; Kasperczyk, Sławomir

doi:10.3390/ijms232112768

Cited by 2 publications

(1 citation statement)

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“…The accumulation of a high level of heavy metals triggers a variety of deadly symptoms, such as reproductive issues and hepato–renal dysfunction ( 32 ). Pb is a neurotoxin that can impair metabolism and exert negative effects on the neurological, gastrointestinal, and renal systems, as well as hemopoiesis and renal function ( 33 ). Pb exposure can block heme synthesis and harm the brain and kidney systems ( Figure 3 ) ( 34 ).…”

Section: Introductionmentioning

confidence: 99%

Heavy metal toxicity in poultry: a comprehensive review

Aljohani

2023

Front. Vet. Sci.

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Arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) have been recognized as most toxic heavy metals that are continuously released into the environment, both from natural sources and from anthropogenic production of fertilizers, industrial activities, and waste disposal. Therefore, As, Cd, Hg, and Pb are found in increasing concentrations in bodies of water, fodder, feed, and in the tissues of livestock, including poultry, in the surroundings of industrial areas, leading to metabolic, structural, and functional abnormalities in various organs in all animals. In poultry, bioaccumulation of As, Pb, Cd, and Hg occurs in many organs (mainly in the kidneys, liver, reproductive organs, and lungs) as a result of continuous exposure to heavy metals. Consumption of Cd lowers the efficiency of feed conversion, egg production, and growth in poultry. Chronic exposure to As, Pb, Cd, and Hg at low doses can change the microscopic structure of tissues (mainly in the brain, liver, kidneys, and reproductive organs) as a result of the increased content of these heavy metals in these tissues. Histopathological changes occurring in the kidneys, liver, and reproductive organs are reflected in their negative impact on enzyme activity and serum biochemical parameters. Metal toxicity is determined by route of exposure, length of exposure, and absorbed dosage, whether chronic and acute. This review presents a discussion of bioaccumulation of As, Cd, Pb, and Hg in poultry and the associated histopathological changes and toxic concentrations in different tissues.

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Section: Introductionmentioning

confidence: 99%

Heavy metal toxicity in poultry: a comprehensive review

Aljohani

2023

Front. Vet. Sci.

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Click evoked otoacoustic emissions in occupational exposure to lead, concentrations of selected essential elements and markers of oxidative stress

Wąsik,

Lisowska,

Słota

et al. 2024

Eur Arch Otorhinolaryngol

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Purpose This study focused on the selected markers of oxidative stress, impact of elevated lead levels on long-term hearing quality. We investigated whether the presence of certain essential minerals might provide protection to the auditory system against the effects of lead (and cadmium) compounds. Methods The research group included 280 male employees of the zinc and lead smelter, which was divided into: L-Pb—low blood lead concentration (PbB) subgroup, H-Pb—high PbB subgroup. Hearing tests were performed using the click evoked otoacoustic emission (CEOAE). Results Zinc protoporphyrin level was significantly higher in the H-Pb subgroup by 68%. Cd concentration was significantly higher in H-Pb by 33%. The Ca concentration was significantly lower in the H-Pb by − 2%. Selected oxidative stress markers concentration were significantly higher in the H-Pb group: malondialdehyde (MDA) by 4%, and lipofuscin (LPS) by 9%. In the CEOAE results showed statistically significant differences between the L-Pb and H-Pb subgroups. Larger negative changes in otoemission amplitude were observed in H-Pb subgroup. All otoemission results showed a statistically significant negative correlation with age, time of work, MDA concentration, and with PbB. Selected CEOAE parameters showed a significant negative correlation with cadmium blood concentration (CdB), and a positive correlation with Ca and Zn. Conclusion Elevated blood lead content in occupational exposure is associated with an increase in MDA and LPS concentration, which negatively correlates with CEOAE parameters. This suggests an important role of oxidative stress in the long-term deterioration of hearing.

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Relationship between Postural Stability, Lead Content, and Selected Parameters of Oxidative Stress

Cited by 2 publications

References 40 publications

Heavy metal toxicity in poultry: a comprehensive review

Heavy metal toxicity in poultry: a comprehensive review

Click evoked otoacoustic emissions in occupational exposure to lead, concentrations of selected essential elements and markers of oxidative stress

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