Relationship between Post-traumatic Stress Disorder and subsequent myocardial infarction: a systematic review and meta-analysis

Jacquet-Smailovic, Murielle; Brennsthul, Marie-Jo; Denis, Ilona; Kirche, Amanda; Tarquinio, Camille; Tarquinio, Cyril

doi:10.1016/j.jad.2021.10.056

Cited by 17 publications

(15 citation statements)

References 31 publications

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“…To test the study hypothesis, given prior evidence on the relationship between CVDs and the affective symptoms of anxiety and depression in the patients [3], and as carried out in previous research [55], these two psychological variables were used as covariates in each analysis in order to test the effects of the psychological interventions on subjective emotional wellbeing (increasing positive affect and reducing negative affect) and management of cardiac and chronic disease self-efficacy over time. As expected, the results revealed that the interaction of the study phases and the experimental groups was significant for all psychological variables analyzed (positive and negative affect, cardiac management selfefficacy, and self-efficacy for managing chronic disease).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Mindfulness and Positive Strengthening mHealth Interventions for the Promotion of Subjective Emotional Wellbeing and Management of Self-Efficacy for Chronic Cardiac Diseases

Tabernero

Gutiérrez‐Domingo

Steca

et al. 2022

JPM

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Intervention in health prevention and treatment via mobile phones is becoming a key element on health promotion. Testing the efficacy of these mobile health (mHealth) psychological interventions for cardiovascular health is necessary as it is a chronic pathology, and it can influence the affective and cognitive states of patients. This research aimed to analyze the effectiveness of two brief psychological interventions—mindfulness and positive strengthening—to promote subjective emotional wellbeing and disease management self-efficacy using mHealth. This was a three-arm intervention and feasibility study, with a pre-post design and three follow-up measures with 105 patients (93 completed all phases) with cardiovascular diseases. Group 1 and 2 received the mindfulness or strengthening intervention, and Group 3 was the control group. The positive–negative affect and management self-efficacy for chronic and cardiovascular diseases were analyzed over time, while anxiety and depression levels were assessed at the beginning of the study. The results showed that mindfulness and positive strengthening interventions both had a positive effect on participants’ affective state and management self-efficacy for the disease in comparison with the control group over time, even after controlling for baseline anxiety and depression levels. Positive strengthening seems to be more effective for improving cardiac self-efficacy, while mindfulness practice was significantly more effective at reducing negative affect at the first face-to-face evaluation.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Mindfulness and Positive Strengthening mHealth Interventions for the Promotion of Subjective Emotional Wellbeing and Management of Self-Efficacy for Chronic Cardiac Diseases

Tabernero

Gutiérrez‐Domingo

Steca

et al. 2022

JPM

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“…Recent meta-analyses have shown that PTSD is an independent risk factor for CVD development even when controlling for depression and coronary risk factors (e.g. high systolic blood pressure [BP], dyslipidemia), and that PTSD is associated with a 49% increase in risk for myocardial infarction onset and hospitalisations or cardiac-related death (Edmondson et al, 2013 ; Jacquet-Smailovic et al, 2022 ). In terms of PTSD symptom clusters, higher re-experiencing and hyperarousal symptoms have been associated with cardiac event recurrence and mortality (Edmondson et al, 2011 ; Presciutti et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The impact of PTSD on associations between sex hormones and cardiovascular disease symptoms

Chen,

Jain,

Merker

et al. 2024

European Journal of Psychotraumatology

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Background: Women have twice the lifetime prevalence of posttraumatic stress disorder (PTSD) relative to men, and PTSD is a known risk factor for cardiovascular disease (CVD). Two sex hormones – estradiol and progesterone – have been found to impact both PTSD and CVD symptomatology, but the way in which sex hormones influence cardiovascular physiology among individuals with PTSD is not well understood. Objective: This study sought to clarify the association between sex hormones, PTSD, and CVD among trauma-exposed women. Method: Sixty-six trauma-exposed women ( M age = 31.45, SD = 8.92) completed a clinical interview for PTSD and self-reported CVD symptoms; estradiol and progesterone were assayed from blood samples. The association between each sex hormone and CVD symptoms was analyzed, controlling for age, systolic blood pressure (BP), and diastolic BP. Results: Neither estradiol nor the PTSD-by-estradiol interaction was significantly associated with CVD symptoms. Higher progesterone and, relatedly, progesterone-to-estradiol ratio (PE ratio) were each significantly associated with greater CVD symptom severity, but only for individuals with lower relative PTSD severity. Conclusions: The findings indicate that PTSD moderates the relationship between progesterone and CVD symptoms, and further research is warranted to reconcile findings in existing literature regarding the direction of and mechanisms behind this relationship.

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“…Women have double the risk of PTSD relative to men. 5 PTSD is associated with a 50% to 60% increased risk of incident CVD 6 and elevated stroke 7 and dementia 8 risk.…”

Section: Introductionmentioning

confidence: 99%

Posttraumatic Stress Disorder Symptoms and Cardiovascular and Brain Health in Women

Thurston,

Jakubowski,

Chang

et al. 2023

JAMA Netw Open

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ImportancePosttraumatic stress disorder (PTSD), cardiovascular disease (CVD), and Alzheimer disease are major public health issues, particularly for women. The implications of PTSD for cardiovascular and brain health for women is poorly understood.ObjectiveTo assess whether PTSD symptoms among midlife women are associated with carotid intima media thickness (IMT), an indicator of carotid atherosclerosis; brain white matter hyperintensity volume (WMHV), an indicator of brain small vessel disease; and cognitive performance and to test a modifying role of the APOEε4 genotype.Design, Setting, and ParticipantsIn this cross-sectional study, participants were enrolled between 2016 to 2021 and completed questionnaires (PTSD Checklist–Civilian Version), physical measures, phlebotomy, neuropsychological testing, a carotid ultrasonographic examination, and 3-Tesla brain magnetic resonance imaging. Participants included community-based women ages 45 to 67 years without a history of CVD, stroke, or dementia. Data were analyzed from July 2022 to September 2023.ExposuresPTSD symptoms.Main Outcomes and MeasuresOutcomes of interest were associations of PTSD symptoms with carotid IMT, brain WMHV, and cognition, assessed in linear regression models. Interactions by APOEε4 were tested. Covariates included age, race and ethnicity, education, and CVD risk factors.ResultsAmong 274 participants (mean [SD] age, 59.03 [4.34] years; 6 Asian participants [2.2%]; 48 Black participants [17.5%]; 215 White participants [78.5%]; 5 multiracial participants [1.8%]), 64 participants (24.71%) were APOEε4 genotype carriers. Higher PTSD symptoms were associated with greater carotid IMT (multivariable β = 0.07 [95% CI, 0.01 to 0.13]; P = .03). Associations of PTSD symptoms with neurocognitive outcomes significantly varied by APOEε4 status. Among women with APOEε4, PTSD symptoms were associated with greater whole-brain WMHV (β = 0.96 [95% CI, 0.30 to 1.63]; P = .009), periventricular WMHV (β = 0.90 [95% CI, 0.24 to 1.56]; P = .02), deep WMHV (β = 1.21 [95% CI, 0.23 to 2.20]; P = .01), and frontal WMHV (β = 1.25 [95% CI, 0.05 to 2.45]; P = .04), as well as with poorer cognition, specifically attention and working memory (β = −3.37 [95% CI, −6.12 to −0.62]; P = .02), semantic fluency (β = −6.01 [95% CI, −10.70 to −1.31]; P = .01), perceptual speed (β = −12.73 [95% CI, −20.71 to −4.75]; P = .002), and processing speed (β = −11.05 [95% CI, −17.80 to −4.30]; P = .002) in multivariable models.Conclusions and RelevanceIn this cross-sectional study of midlife women, greater PTSD symptoms were associated with higher carotid atherosclerosis and, among women who were APOEε4 carriers, greater brain small vessel disease and poorer cognitive performance. These findings point to the adverse implications of PTSD symptoms for cardiovascular and neurocognitive health among women in midlife, particularly for women who are APOEε4 carriers.

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Relationship between Post-traumatic Stress Disorder and subsequent myocardial infarction: a systematic review and meta-analysis

Cited by 17 publications

References 31 publications

Effectiveness of Mindfulness and Positive Strengthening mHealth Interventions for the Promotion of Subjective Emotional Wellbeing and Management of Self-Efficacy for Chronic Cardiac Diseases

Effectiveness of Mindfulness and Positive Strengthening mHealth Interventions for the Promotion of Subjective Emotional Wellbeing and Management of Self-Efficacy for Chronic Cardiac Diseases

The impact of PTSD on associations between sex hormones and cardiovascular disease symptoms

Posttraumatic Stress Disorder Symptoms and Cardiovascular and Brain Health in Women

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