Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms

Sun, Wei; Li, Zirong; Shi, Zhengcai; Wang, Bailiang; Gao, Fuqiang; Yang, Yurun; Guo, Wanshou

doi:10.1007/s00590-013-1223-0

Cited by 20 publications

(23 citation statements)

References 19 publications

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“…This endeavor revealed a relationship between PAI-1 4G/5G gene polymorphism and post-SARS osteonecrosis mediated by the mechanisms of intravascular coagulation-induced thrombosis and resulting fibrin thrombi in the area of osteonecrosis. 24 In support of our assumptions, PAI-1, vWF, and factor VIII were revealed to be increased in all 4 studied patients with severe and deleterious COVID-19 associated pneumonia. 25 All these findings put forward that patients' underlining genetic variations might be responsible for different thrombotic events risks in the novel coronavirus disease.…”

supporting

confidence: 77%

Unpuzzling COVID-19 Prothrombotic State: Are Preexisting Thrombophilic Risk Profiles Responsible for Heterogenous Thrombotic Events?

Burlacu

Genovesi

Popa

et al. 2020

Clin Appl Thromb Hemost

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supporting

confidence: 77%

Unpuzzling COVID-19 Prothrombotic State: Are Preexisting Thrombophilic Risk Profiles Responsible for Heterogenous Thrombotic Events?

Burlacu

Genovesi

Popa

et al. 2020

Clin Appl Thromb Hemost

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“…The osteonecrosis of the femoral head (ONFH) is common in young adults, and it is the leading cause of hip joint replacements in many Asian countries including China [ 1 ]. Although the disease remains well-known, it is not fully understood because of the difficulty in early diagnosis, miscellaneous etiologies, unclear pathogenesis, and undetermined successful treatment [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Various efforts have been made in an attempt to enhance the healing of osseous defects in the femoral head before collapse occurs. The treatment approach is determined based on early diagnosis and preservation of the affected hip [ 1 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

High-Energy Extracorporeal Shock Wave for Early Stage Osteonecrosis of the Femoral Head: A Single-Center Case Series

Gao

Sun

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Our retrospective study assessed the effects of treatment of early stage ONFH with extracorporeal shock wave therapy. 335 patients (528 hips) were treated with shockwave therapy in our institution. Each patient underwent two sessions. The hips were divided into two groups according to whether the lateral pillar of the femoral head (LPFH) was preserved: LPFH and non-LPFH groups. Patients were followed up at 3, 6, and 12 months after the treatment. Most of the patients (83.9% hips) demonstrated pain reduction and improved mobility of the treated joint (visual analogue scale score, P = 0.00006; Harris hip score, P = 0.00091). During the follow-up period, 16 hips failed following femoral head collapse and required hip arthroplasty (2 hips in LPFH group and 14 hips in non-LPFH group). The lesion size decreased after ESWT. However, the differences were statistically not significant (LPFH group, P = 0.091; non-LPFH group, P = 0.087). A significant reduction in bone marrow edema was observed after treatment (LPFH group, P = 0.007; non-LPFH group, P = 0.016). High-energy extracorporeal shock wave therapy resulted in considerable improvement in early stage ONFH, which can effectively relieve pain and improve the function of the hip.

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“…Thrombosis formation is influenced by PAI-1 gene polymorphisms. [ 24 ] Accumulating evidences have suggested that the PAI-1 gene 4G/5G polymorphism might be an etiological factor for ON occurrence in renal transplant patients, [ 25 ] post-SARS patients [ 26 ] and glucocorticoid-induced ON patients. [ 27 ] There also other polymorphisms exist in the PAI-1 gene, such as rs6092 (exon 1) and rs7242 (3′UTR).…”

Section: Discussionmentioning

confidence: 99%

Association between plasminogen activator inhibitor gene polymorphisms and osteonecrosis of the femoral head susceptibility

Liu

Yuan

et al. 2017

Medicine

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This study aimed to analyze the correlation of the plasminogen activator inhibitor (PAI-1) gene polymorphisms (rs6092 and rs7242) with susceptibility of osteonecrosis of the femoral head (ONFH).This case-control study included 106 ONFH patients and 151 healthy controls. PAI-1 polymorphisms were genotyped by polymerase chain reaction (PCR) with direct sequencing. The genotype distribution of polymorphism in the control group was checked with the status of Hardy–Weinberg equilibrium (HWE). The χ2 test was applied to compare the genotypes of polymorphisms between the case and control groups. The association intensity between PAI-1 polymorphisms and ONFH risk was estimated by odds ratios (ORs) and 95% confidence intervals (95% CI). The linkage disequilibrium of PAI-1 polymorphisms was analyzed by Haploview.We found that the genotypes and alleles of PAI-1 rs6092 and rs7242 polymorphisms had no obvious association with the risk of ONFH (P >.05). But the strong linkage disequilibrium existed between rs6092 and rs7242 polymorphisms and haplotype G-T was significantly associated with the decreased risk of ONFH occurrence (OR = 0.666, 95%CI = 0.445–0.998).PAI-1 rs6092 and rs7242 polymorphisms are not associated with ONFH development, but haplotype G-T may be a protective factor of ONFH.

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Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms

Abstract: Plasminogen activator inhibitor-1 is sensitive blood symbol for screening high-risk susceptible population; 4G/4G PAI-1 genotype may be an etiological factor in osteonecrosis.

Cited by 20 publications

References 19 publications

Unpuzzling COVID-19 Prothrombotic State: Are Preexisting Thrombophilic Risk Profiles Responsible for Heterogenous Thrombotic Events?

Unpuzzling COVID-19 Prothrombotic State: Are Preexisting Thrombophilic Risk Profiles Responsible for Heterogenous Thrombotic Events?

High-Energy Extracorporeal Shock Wave for Early Stage Osteonecrosis of the Femoral Head: A Single-Center Case Series

Association between plasminogen activator inhibitor gene polymorphisms and osteonecrosis of the femoral head susceptibility

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