Relationship between Polymorphism of the Angiotensin-Converting Enzyme Gene and the Response to Angiotensin-Converting Enzyme Inhibition in Hypertensive Patients

Abstract

The aim of this study was to investigate the relationship between polymorphism of the angiotensin-converting enzyme (ACE) gene and the blood pressure response to ACE inhibition in a hypertensive cohort. Imidapril (5--10 mg/day) or benazepril (10--20 mg/day) was administered for 6 weeks to 517 essential hyperten-

A Physiologic Approach to the Pharmacogenomics of Hypertension

“…These endpoints have ranged from improvement in measured hemodynamics to reduction in proteinuria to BP response. However, significant conflicting data have since been reported that reveal no association between rs1799752 and ACEI or ARB BP response 17,[33][34][35][36][37][38][39] . Although evidence does not support the use of rs1799752 as a predictor of ACEI or ARB response, a few studies suggest this SNP may remain a predictor of diuretic response [40][41][42] .…”

Sistema renina-angiotensina: é possível identificar genes de suscetibilidade à hipertensão?

“…The association between ACE I/D polymorphism and hypertension 10,24 has been reported, with high morbidity rate for hypertensives and diabetics, although studies conducted with Caucasian populations have not detected a more impacting effect of that gene in hypertensives 18,[38][39][40][41][42] . A study where Blood Pressure Ambulatory Monitoring (ABPM) was used, BP and pressure load were related to ACE I/D polymorphism 43 .…”

A Single Nucleotide Polymorphism in the Carboxylesterase Gene Is Associated with the Responsiveness to Imidapril Medication and the Promoter Activity

“…It has been reported that the ACE I/D polymorphism may influence the ability of imidapril to prevent restenosis after percutaneous transluminal coronary angioplasty (16). However, the responsiveness to imidapril showed no association with the ACE I/D genotype (17), and the genes and the genotypes that are associated with the response to this drug remain largely unknown.…”