Relationship between polycythemia and in-hospital mortality in chronic obstructive pulmonary disease patients with low-risk pulmonary embolism

Chughtai, Aamer; Jiang, Hongli; Gao, Lingyun; Yang, Yan; Yang, Yang; Liu, Yuejian; Zhen-liang, Xie; Li, Weimin

doi:10.21037/jtd.2016.11.31

Cited by 11 publications

(9 citation statements)

References 52 publications

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“…Two other cohort studies, each less than 300 participants, evaluated the prevalence of polycythemia in European COPD outpatients [ 12 , 13 ]. Studies based on hospitalized COPD patients or severe COPD patients receiving LTOT may have inaccurate polycythemia prevalence estimates due to selection and misclassification biases [ 10 , 11 , 37 ]. The COPDGene study prospectively enrolled a large number of non-Hispanic white and African American current and former smokers with and without COPD from multiple clinical centers across the US.…”

Section: Discussionmentioning

confidence: 99%

Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors

et al. 2021

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Background Secondary polycythemia is associated with cigarette smoking and chronic obstructive pulmonary disease (COPD). However, the prevalence of polycythemia in COPD and the contributing risk factors for polycythemia in COPD have not been extensively studied. Methods We analyzed the presence of secondary polycythemia in current and former smokers with moderate to very severe COPD at the five-year follow-up visit in the observational COPDGene study. We used logistic regression to evaluate the association of polycythemia with age, sex, race, altitude, current smoking status, spirometry, diffusing capacity for carbon monoxide (DLCO), quantitative chest CT measurements (including emphysema, airway wall thickness, and pulmonary artery to aorta diameter ratio), resting hypoxemia, exercise-induced hypoxemia, and long-term oxygen therapy. Results In a total of 1928 COPDGene participants with moderate to very severe COPD, secondary polycythemia was found in 97 (9.2%) male and 31 (3.5%) female participants. In a multivariable logistic model, severe resting hypoxemia (OR 3.50, 95% CI 1.41–8.66), impaired DLCO (OR 1.28 for each 10-percent decrease in DLCO % predicted, CI 1.09–1.49), male sex (OR 3.60, CI 2.20–5.90), non-Hispanic white race (OR 3.33, CI 1.71–6.50), current smoking (OR 2.55, CI 1.49–4.38), and enrollment in the Denver clinical center (OR 4.42, CI 2.38–8.21) were associated with higher risk for polycythemia. In addition, continuous (OR 0.13, CI 0.05–0.35) and nocturnal (OR 0.46, CI 0.21–0.97) supplemental oxygen were associated with lower risk for polycythemia. Results were similar after excluding participants with anemia and participants enrolled at the Denver clinical center. Conclusions In a large cohort of individuals with moderate to very severe COPD, male sex, current smoking, enrollment at the Denver clinical center, impaired DLCO, and severe hypoxemia were associated with increased risk for secondary polycythemia. Continuous or nocturnal supplemental oxygen use were associated with decreased risk for polycythemia.

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Section: Discussionmentioning

confidence: 99%

Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors

et al. 2021

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“…The risk of PE in this setting is also unclear (Nadeem et al, 2013) as an increased Hct in the general population is also associated with increased VTE risk (Braekkan et al, 2010). A recent study suggests that patients with COPD at low risk of VTE had increased incidence of pulmonary embolism if they had concurrent erythrocytosis (Guo et al, 2016).…”

Section: Hypoxic Pulmonary Diseasementioning

confidence: 99%

A guideline for the management of specific situations in polycythaemia vera and secondary erythrocytosis

et al. 2018

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“…A total of 8 trials (23,899 patients) were included for analysis (14)(15)(16)(17)(18)(19)(20)(21). Table 1 describes the characteristics of included studies.…”

Section: Resultsmentioning

confidence: 99%

Correlation between the severity of chronic inflammatory respiratory disorders and the frequency of venous thromboembolism: meta-analysis

Pak¹,

S²,

Ruzieh³

2017

Southwest J Pulm Crit Care

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The present study aims to integrate the growing body of evidence on the possible association between the severity of chronic inflammatory respiratory disorders (CIRDs) and the frequency of venous thromboembolism (VTE). Eight studies were analyzed to assess the correlation between the severity of CIRDs and the incidence of VTE. Our results suggest that there is no significant increased risk of VTE in patients with severe CIRD compared to mild or moderate CIRD, OR=0.92 (95% CI 0.59 -1.43; I 2 = 74%). Further studies are indicated to explore this possible association. Gaining a better understanding of the VTE risk for patients with CIRDs will enable clinicians to provide better individualized risk management and preventive care.

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Relationship between polycythemia and in-hospital mortality in chronic obstructive pulmonary disease patients with low-risk pulmonary embolism

Abstract: Polycythemia is an independent risk factor for all-cause in-hospital mortality in COPD patients with PE at low risk.

Cited by 11 publications

References 52 publications

Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors

Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors

A guideline for the management of specific situations in polycythaemia vera and secondary erythrocytosis

Correlation between the severity of chronic inflammatory respiratory disorders and the frequency of venous thromboembolism: meta-analysis

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