Relationship between platelet-to-lymphocyte ratio and the presence and severity of coronary artery ectasia

Kundi, Harun; Gök, Murat; Çetın, Mustafa; Kızıltunç, Emrullah; Çiçekçioğlu, Hülya; Çetin, Mustafa; Karayiğit, Orhan; Örnek, Ender

doi:10.14744/anatoljcardiol.2015.6639

Cited by 14 publications

(24 citation statements)

References 25 publications

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“…Recently, increased PLR and decreased LMR have been reported to be associated with disease activity in many diseases. [ 33 – 37 ] But they could not show these correlations with other inflammatory marks such as hs-CRP or ESR. These serum inflammatory parameters can be considered as appropriate, confirmatory tests for hs-CRP and ESR.…”

Section: Discussionmentioning

confidence: 99%

Serum PLR and LMR in Behçet's disease

Jiang¹,

Zang

Li³

2017

Medicine

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The aim of this study is to determine platelet to lymphocyte ratio (PLR) and lymphocytes to monocytes ratio (LMR) levels in Behçet's disease (BD) and to investigate their relationships with disease activity.Hematological and inflammatory parameters including high-sensitivity C-reactive proteins (hs-CRP), erythrocyte sedimentation rate (ESR), PLR, and LMR were examined in BD and healthy controls.Data from 140 patients with BD (108 with active and 32 with inactive disease) and 107 controls were enrolled. PLR (153.21 ± 65.44, 106.20 ± 28.91, P <.001, respectively) was remarkably higher, whereas LMR (5.37 ± 5.47, 8.95 ± 5.84, P <.001, respectively) was significantly lower in BD than in controls. Active BD patients had significantly higher PLR (159.20 vs 131.14, P = .037), ESR (38.30 vs 24.55, P = .017), and hs-CRP (30.20 vs 17.21, P = .027) than those with inactive BD. However, no significant difference in LMR was found between the groups. Moreover, PLR was positively correlated with BDCAF (r = 0.193, P <.05), hs-CRP (r = 0.402, P <.01), and ESR (r = 0.284, P <.01), whereas LMR was negatively correlated with BDCAF (r = –0.175, P <.05), hs-CPR (r = –0.263, P <.01), and ESR (r = –0.175, P <.05). Additionally, both PLR and LMR were shown to be independent factors for BD by multivariate logistic regression analysis. Furthermore, a PLR level of 124.63 was determined as the best cut-off value by ROC analysis (sensitivity 64.3%, specificity 78.0%, and the area under the ROC curve 0. 753).PLR was elevated in active BD as compared to inactive BD. PLR may be a reliable, cost-effective, and novel potential parameter to help evaluate disease activity in BD.

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Section: Discussionmentioning

confidence: 99%

Serum PLR and LMR in Behçet's disease

Jiang¹,

Zang

Li³

2017

Medicine

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“…In recent years, PLR, derived from platelet and lymphocyte counts and indicated as a useful indicator of systemic inflammatory response, was firstly used as a prognostic marker of some oncological diseases [20][21][22]. Then, this marker was shown to be associated with inflammation in cardiovascular diseases [11][12][13][14][15]. In addition, PLR has been reported to correlate with other inflammatory markers such as CRP and fibrinogen, which have proven to be predictive and prognostic in cardiovascular disease [23].…”

Section: Discussionmentioning

confidence: 99%

“…Low blood lymphocyte count has been shown to be associated with poor cardiovascular outcomes in coronary artery disease (CAD) [9,10]. Platelet-to-lymphocyte ratio (PLR), derived from these values, is a useful parameter showing the degree of the inflammatory response, which is used as an important prognostic factor in many cardiovascular diseases [11][12][13][14][15]. In our previous study, we showed that high PLR levels in patients with ACS increase in-hospital mortality [12].…”

Section: Introductionmentioning

confidence: 99%

Platelet-to-lymphocyte ratio is a predictor of long-term mortality in patients with acute coronary syndrome

Oylumlu

Arslan

Polat

et al. 2020

pwki

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Introduction: Atherosclerosis is a chronic inflammatory process and inflammation is an important component of acute coronary syndrome (ACS). Platelet-to-lymphocyte ratio (PLR) is a useful parameter showing the degree of the inflammatory response. Aim: To explore the association between PLR and long-term mortality in patients with ACS. Material and methods: A total of 538 patients who had a diagnosis of ACS between January 2012 and August 2013 were followed up to 60 months. On admission, blood sampling to calculate PLR and detailed clinical data were obtained. Results: In total, 538 patients with a mean age of 61.5 ±13.1 years (69% male) were enrolled in the study. Median follow-up was 79 months (IQR: 74-83 months). Patients were divided into 3 tertiles based on PLR levels. Five-year mortality of the patients was significantly higher among patients in the upper PLR tertile when compared with the lower and middle PLR tertile groups (55 (30.7%) vs. 27 (15.0%) and 34 (19.0%); p < 0.001, p = 0.010 respectively). In the Cox regression analysis, a high level of PLR was an independent predictor of 5-year mortality (OR = 1.005, 95% CI: 1.001-1.008, p = 0.004). Kaplan-Meier analysis according to the long-term mortality-free survival revealed the higher occurrence of mortality in the third PLR tertile group compared to the first (p < 0.001) and second tertiles (p = 0.009). Conclusions: PLR, which is an easily calculated and universally available marker, may be useful in long-term risk classification of patients presenting with ACS.

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“…First described in 1967 as an indicator of ozone exposure, 10 NLR has shown prognostic value in different cardiovascular conditions including stable coronary artery disease, acute coronary syndromes, HF, and coronary artery bypass grafting (CABG). 11 On the other hand, platelet-to-lymphocyte ratio (PLR) was first described in 2008 as a prognostic marker in periampullary cancer 12 and has also shown prognostic value in patients with ST elevation acute myocardial infarction [13][14][15] and stable coronary artery disease 16,17 and in patients with an implantable cardioverter defibrillator. 18 Despite raising evidence supporting the use of NLR and PLR in cardiovascular disease, no study has evaluated the role of these markers in patients undergoing HTX.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as predictors of survival after heart transplantation

et al. 2017

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AimsThe aim of this study was to evaluate whether neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) predict outcome in heart failure (HF) patients undergoing heart transplantation (HTX).Methods and resultsData from 111 HF patients undergoing HTX 2010–2015 were retrospectively reviewed. NLR and PLR were calculated before HTX, immediately after HTX, and at 6 and 24 hours. Primary endpoint was in‐hospital mortality, and secondary endpoints were 1 year mortality and renal replacement therapy (RRT). Prognostic factors were assessed by multivariate analysis, and the predictive values of NLR and PLR for mortality were compared. The discriminatory performance for predicting in‐hospital mortality was better for NLR [area under the receiver operating characteristic curve (AUC) = 0.644, 95% confidence interval 0.492–0.797] than for PLR (AUC = 0.599, 95% confidence interval 0.423–0.776). Best cut‐off value was 2.41 for NLR (sensitivity 86%, specificity 67%) and 92.5 for PLR (sensitivity 86%, specificity 68%). When divided according to best cut‐off value, in‐hospital mortality was significantly higher in the high NLR group (17.5% vs. 3.2%, P < 0.05), but not in the high PLR group (16.5% vs. 6.3%, P = ns). One year mortality was not significantly higher for either group (37.5% vs. 6.5% for NLR; 36.7% vs. 9.4% for PLR, P = ns for both), while RRT was significantly higher in both the NLR and PLR high groups (33.8% vs. 0%; 32.9% vs. 3.1%, respectively, P < 0.001). Multivariate analysis indicated that only high NLR (hazard ratio = 3.403, P < 0.05) and pre‐transplant diabetes (hazard ratio = 3.364, P < 0.05) were independent prognostic factors for 1 year mortality.ConclusionsHigh NLR was a predictor for in‐hospital mortality, and an independent prognostic factor for 1 year mortality. Both high NLR and high PLR were predictors for RRT.

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Relationship between platelet-to-lymphocyte ratio and the presence and severity of coronary artery ectasia

Cited by 14 publications

References 25 publications

Serum PLR and LMR in Behçet's disease

Serum PLR and LMR in Behçet's disease

Platelet-to-lymphocyte ratio is a predictor of long-term mortality in patients with acute coronary syndrome

Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as predictors of survival after heart transplantation

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