Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi

Johnston, W. Thomas; Mutalima, Nora; Sun, Dengming; Emmanuel, Benjamin; Bhatia, Kishor; Aka, Peter; Wu, Xiaolin; Borgstein, Eric; Liomba, George N.; Kamiza, Steve; Mkandawire, Nyengo; Batumba, Mkume; Carpenter, Lucy; Jaffe, Harold W.; Molyneux, Elizabeth; Goedert, James J.; Soppet, Daniel; Newton, Robert; Mbulaiteye, Sam M.

doi:10.1038/srep03741

Cited by 44 publications

(57 citation statements)

References 32 publications

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“…Research confirmed Epstein-Barr virus (EBV) as a causative organism for eBL (Rowe et al, 2014). Further studies have elucidated the roles of malaria infections and EBV in tumourigenesis (Johnston et al, 2014). BL is a highly aggressive B cell NHL associated with a translocation involving the MYC oncogene on chromosome 8.…”

Section: Haematological Cancersmentioning

confidence: 99%

Haematological cancers in African children: progress and challenges

et al. 2017

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SummaryCancer is increasingly important in low and middle-income settings where infectious diseases are declining. Childhood cancers treated in well-resourced centres have excellent outcomes with more than 80% survival. This success is not reflected in low-income settings where challenges involve every step on the care pathway. Access to diagnosis, delayed presentation, advanced disease, co-morbidities and underlying malnutrition make treatment difficult. Treatments are costly for impoverished families. Yet, the common haematological malignancies (Burkitt lymphoma, Hodgkin lymphoma, non Hodgkin lymphoma) are relatively easy to diagnose and, when managed with simple chemotherapy protocols, give limited but good results. As funding becomes available for cancer research we must ensure that the care and cure of these children is top of the agenda. There is already evidence of improved outcomes in middle-income countries. For others there is a long journey ahead.

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Section: Haematological Cancersmentioning

confidence: 99%

Haematological cancers in African children: progress and challenges

et al. 2017

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“…2 The ecological association between eBL and P. falciparum was shown in the 1970s, 1 but there is still limited evidence from studies examining this association at an individual level. [3][4][5][6][7][8] In 2012, the International Agency for Research on Cancer classified P. falciparum infection in holoendemic areas as "probably carcinogenic to humans." 9 A better description of eBL epidemiology is needed to enhance current understanding of the etiology of the disease.…”

mentioning

confidence: 99%

“…Endemic Burkitt lymphoma (eBL) is a B-cell non-Hodgkin lymphoma genetically characterized by a chromosomal translocation t (8,14) that results in deregulation of the c-MYC oncogene. eBL is the main pediatric cancer in equatorial Africa accounting for about 50% of childhood cancers, and 90% of lymphomas.…”

mentioning

confidence: 99%

Incidence of Endemic Burkitt Lymphoma in Three Regions of Mozambique

O’Callaghan-Gordo

Casabonne

Carrilho

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Data on the burden and incidence of endemic Burkitt lymphoma (eBL) across Mozambique are scarce. We retrospectively retrieved information on eBL cases from reports of the three main hospitals of Mozambique: Maputo Central Hospital (MCH), Beira Central Hospital (BCH), and Nampula Central Hospital (NCH) between 2004 and 2014. For 2015, we prospectively collected information of new eBL cases attending these hospitals. A total of 512 eBL cases were reported between 2004 and 2015: 153 eBL cases were reported in MCH, 195 in BCH, and 164 in NCH. Mean age of cases was 6.9 years (standard deviation = 2.8); 63% (319/504) of cases were males. For 2015, the estimated incidence rate of eBL was 2.0, 1.7, and 3.9 per 10 6 person-year at risk in MCH, BCH, and NCH, respectively. Incidence was higher in NCH (northern Mozambique), where intensity of malaria transmission is higher. Data presented show that eBL is a common pediatric malignancy in Mozambique, as observed in neighboring countries.

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“…Varios estudios han demostrado que la parasitemia, la prevalencia de infección por Plasmodium y algunas variantes genéticas se relacionan directamente con el desarrollo del linforma. Si bien los mecanismos biológicos y oncogénicos no se han establecido completamente, se ha identificado la activación atípica de células B de memoria cuya inducción puede estar mediada por el imbalance oxidativo propio de la infección parasitaria 8 .…”

Section: Artículo Originalunclassified