Relationship between plasminogen activator inhibitor-1 antigen, leptin, and fat mass in obese children and adolescents

Sudi, Karl; Gallistl, Siegfried; Weinhandl, Gudrun; Muntean, W.; Borkenstein, Martin

doi:10.1053/meta.2000.6736

Cited by 36 publications

(28 citation statements)

References 39 publications

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“…35 Our results coincide with these findings, although our age group is lower than that studied by these other authors. In the single linear correlation analysis, for the obese group, leptin correlated positively with PAI-1, although in a multivariant regression analysis leptin is not an independent predictive factor for PAI-1.…”

Section: Tablesupporting

confidence: 92%

Relationship between high plasma leptin concentrations and metabolic syndrome in obese pre-pubertal children

Valle

Gascón

Martos³

et al. 2003

Int J Obes

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OBJECTIVE: To evaluate the relationship between serum leptin levels and metabolic syndrome, fasting insulin level and anthropometric index in obese pre-pubertal children. DESIGN: A cross-sectional study was carried out on obese children. SUBJECTS: A study was made of 41 obese children (aged 6 -9 y) and the same number of non-obese children (control group), matched by age and sex. METHODS: Body mass index (BMI), waist=hip ratio (WHR) and blood pressure were determined in each child. Serum leptin, glucose, insulin, lipid profile, sex hormone binding globulin (SHBG), plasminogen activator inhibitor-1 (PAI-1), tissueplasminogen activator (t-PA) and fibrinogen were all measured. RESULTS: The serum leptin level was significantly higher in obese children (15.47 vs 4.73 ng=ml). In the obese group, leptin showed a positive correlation with BMI (P < 0.001), insulin (P < 0.001), triglycerides (P < 0.05), PAI-1 (P < 0.05) and t-PA (P < 0.05), and correlated negatively with SHBG (P < 0.01), apolipoprotein A-I (P < 0.05) and high-density lipoproteins cholesterol (HDL-C) (P < 0.05). Corrected for BMI and WHR, leptin (P partial ¼ 0.002) is only an independent predictive factor for basal insulin. Using multivariant regression analysis, only insulin (P partial ¼ 0.003) and BMI (P partial ¼ 0.018) were independent predictive factors for leptin. CONCLUSION: For this age group, high leptin resistance may be another component of metabolic syndrome, and may be involved in its etiopathogenesis. The involvement of leptin in this syndrome may be indirect, modulating the insulin's action.

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Section: Tablesupporting

confidence: 92%

Relationship between high plasma leptin concentrations and metabolic syndrome in obese pre-pubertal children

Valle

Gascón

Martos³

et al. 2003

Int J Obes

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“…In multiple linear regression analysis, PAI-1-Ag and log triglycerides explained independent signi®cant proportions of the variance of tPA-Ag (r 2 0.19, P`0.01). As partially described previously, 23 PAI-1-Ag correlated Haemostatic risk factors in childhood obesity S Gallistl et al signi®cantly with log insulin (r 0.43, P 0.002), log C-peptide (r 0.48, P`0.001), log VLDL (r 0.38, P 0.009), and log triglycerides (r 0.4, P 0.005). After adjustment for FM the correlations between PAI-1-Ag and the determined metabolic parameters did not remain signi®cant.…”

Section: Relation Between Haemostatic and Metabolic Risk Factorssupporting

confidence: 64%

“…25 In agreement with the assumption that adipose tissue plays a major role in the regulation of plasma PAI-1 levels, we have demonstrated previously that only FM contributed to the variance in PAI-1-Ag in obese children and adolescents. 23 Recent data suggest that subcutaneous adipose tissue expresses more PAI-1 than visceral adipose tissue, 26 which contradicts the ®nding that the plasma PAI-1 level correlates with visceral but not subcutaneous fat area as assessed by computed tomography. 27 We did not investigate body fat distribution, since computed tomography was no option in our study population and it has been suggested that assessment of the waist-to-hip ratio cannot be uncritically recommended as measure of body fat distribution in children.…”

Section: Discussionmentioning

confidence: 98%

Determinants of haemostatic risk factors for coronary heart disease in obese children and adolescents

Gallistl¹,

Sudi

Borkenstein³

et al. 2000

Int J Obes

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OBJECTIVE: To investigate the contribution of serum lipids, parameters of glucose metabolism, body composition and cardiovascular ®tness to the variance of several haemostatic risk factors for coronary heart disease (CHD) in obese children and adolescents. SUBJECTS AND MEASUREMENTS: Forty-two healthy, obese children and adolescents (20 male, 22 female, age 12.6 AE 3.2 y; body mass index (BMI), 30.4 AE 5.3 kgam 2 ), were screened for haemostatic and metabolic risk factors for CHD. Thirty-®ve of the participants (18 male, age 13.5 AE 2.9 y; BMI, 29.9 AE 4.5 kgam 2 ; 17 female, age 12.8 AE 2.1 y, BMI, 31.1 AE 5.3 kgam 2 ) were assessed for cardiovascular ®tness by means of incremental cycle ergometer exercise. RESULTS: After adjustment for age, fat mass correlated signi®cantly with plasminogen activator inhibitor-1 antigen (PAI-1-Ag) in boys and girls and factor VIIc only in girls. Children with lower power output ( 2.77 Wakg) showed signi®cantly higher values for factor VIIc, ®brinogen and tissue-type plasminogen activator antigen (tPA-Ag). Neither body composition nor cardiovascular ®tness contributed independently to the variance of the determined haemostatic risk factors, except PAI-1-Ag, which has been shown to be determined by fat mass. In multiple linear regression analysis, triglycerides and PAI-1-Ag explained signi®cant independent proportions of the variance of tPA-Ag. Factor VIIc was explained by C-peptide, insulin and ®brinogen. Von Willebrand factor antigen (vWF-Ag) was signi®cantly related to glucose and insulin. CONCLUSION: The results suggest that in obese children and adolescents the haemostatic risk factors factor VIIc, vWF-Ag and tPA-Ag are mainly determinated by plasma insulin and triglyceride concentrations, but are primarily independent of body composition and cardiovascular ®tness.

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“…Hispanic adults with impaired glucose tolerance and diabetes have increased levels of PAI-1, which are associated with BMI, fasting insulin, and proinsulin and are negatively associated with the ISI (33). This strong association between PAI-1 levels and obesity and insulin resistance has also been identified in children and adolescents (34,35). Accordingly, our data show that both PAI-1 and t-PA levels are strongly associated with BMI and truncal fat in Hispanic youth as well as with hs-CRP.…”

Section: Multivariate Analysismentioning

confidence: 82%

Overweight Latino Children and Adolescents Have Marked Endothelial Dysfunction and Subclinical Vascular Inflammation in Association With Excess Body Fat and Insulin Resistance

et al. 2008

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OBJECTIVE -We measured plasma markers of endothelial dysfunction, vascular inflammation, and pro-coagulation in obese Hispanic/Latino children and adolescents with normal glucose tolerance and determined their relationship to body composition and indexes of glucose and lipid metabolism. RESEARCH DESIGN AND METHODS-A total of 38 lean or obese Hispanic children and adolescents (10 -18 years of age) were selected. The overweight group (n ϭ 21) had a BMI Ͼ85th percentile for their age and sex, and the lean group (n ϭ 17) had a BMI between the 25th and 50th percentiles. Studies included an oral glucose tolerance test, measurements of plasma glucose and lipids, several markers of endothelial function and inflammation, and determination of body composition by dual X-ray absorptiometry.RESULTS -The obese group had higher systolic blood pressure and plasma triglycerides and was more insulin resistant than the lean group. The obese group also had higher plasma soluble intercellular adhesion molecule (259.5 Ϯ 60.0 vs. 223.2 Ϯ 47.5 ng/ml, P ϭ 0.047), tumor necrosis factor-␣ (2.57 Ϯ 1.1 vs. 1.74 Ϯ 0.6 pg/ml, P ϭ 0.008), high-sensitivity C-reactive protein (2.0 vs. 0.13 mg/l, P Ͻ 0.0001), plasminogen-activated inhibitor-1 (47.0 Ϯ 35.7 vs. 12.0 Ϯ 5.2 ng/ml, P Ͻ 0.0001), tissue plasminogen activator (6.1 Ϯ 1.9 vs. 4.1 Ϯ 0.8 ng/ml, P ϭ 0.001), and white blood cell count (6.9 vs. 5.3 ϫ 10 3 , P ϭ 0.031) and lower levels of adiponectin (8.7 Ϯ 3.3 vs. 12.6 Ϯ 5.2 g/ml, P ϭ 0.022). No significant differences were observed for soluble vascular cell adhesion molecule or interleukin-6. CONCLUSIONS -Overweight Hispanic children and adolescents with normal glucose tolerance exhibit increased plasma markers of endothelial dysfunction and subclinical inflammation in association with obesity and insulin resistance. These abnormalities may predispose them to the development of type 2 diabetes and cardiovascular disease.

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Relationship between plasminogen activator inhibitor-1 antigen, leptin, and fat mass in obese children and adolescents

Cited by 36 publications

References 39 publications

Relationship between high plasma leptin concentrations and metabolic syndrome in obese pre-pubertal children

Relationship between high plasma leptin concentrations and metabolic syndrome in obese pre-pubertal children

Determinants of haemostatic risk factors for coronary heart disease in obese children and adolescents

Overweight Latino Children and Adolescents Have Marked Endothelial Dysfunction and Subclinical Vascular Inflammation in Association With Excess Body Fat and Insulin Resistance

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