Relationship between Plasma Triglycerides and Removal of Chylomicrons*

Nestel, Paul J.

doi:10.1172/jci104980

Cited by 242 publications

(58 citation statements)

References 12 publications

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“…Figure 3C illustrates that HDL cholesteryl ester as percentage of plasma declined after an oral fat load from 10% (6-11) to 8% (4-11), p<0.05, analyzed from 0 to 8 hours. LDL and TRL cholesteryl ester did not change significantly from 8 1 % (78-88) to 82% (79-88), and from 10% (5-12) to 11% (5)(6)(7)(8)(9)(10)(11)(12)(13)(14), respectively.…”

Section: Cholesteryi Ester Distribution Between Upoprotelnsmentioning

confidence: 84%

Alimentary lipemia-induced redistribution of cholesteryl ester between lipoproteins. Studies in normolipidemic, combined hyperlipidemic, and hypercholesterolemic men.

et al. 1989

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Section: Cholesteryi Ester Distribution Between Upoprotelnsmentioning

confidence: 84%

Alimentary lipemia-induced redistribution of cholesteryl ester between lipoproteins. Studies in normolipidemic, combined hyperlipidemic, and hypercholesterolemic men.

et al. 1989

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“…For example, higher plasma VLDL triglyceride levels are associated with lower plasma HDL-C levels, 531 smaller, denser LDL particles, 5 -32 and increased postprandial accumu- lation of triglyceride-rich particles of intestinal origin. 33 All of these effects may enhance the atherogenicity of circulating lipoproteins and increase coronary disease risk in men compared with women. 313234 The differences in lipoprotein pattern between men and women (higher triglycerides, lower HDL-C, and smaller, denser LDL particles) are paralleled by the differences in lipoprotein pattern between people with non-insulin-dependent diabetes (NIDDM) and people with normal glucose tolerance.…”

Section: Discussionmentioning

confidence: 99%

Relation of plasma triglyceride and apoB levels to insulin-mediated suppression of nonesterified fatty acids. Possible explanation for sex differences in lipoprotein pattern.

McKeigue

Laws

Chen

et al. 1993

Arterioscler Thromb

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To test whether a sex difference in insulin-mediated suppression of nonesterified fatty acids (NEFAs) could account for sex differences in plasma triglyceride levels, we studied 632 normoglycemic men and women of European and South Asian descent aged 40 to 69 years. Mean fasting NEFA levels were 19% higher in women than in men. Between fasting and 2 hours after a 75-g oral glucose load, NEFA levels fell by 69% in women and 55% in men, so that mean NEFA levels at 2 hours after loading were 19% lower in women than in men. Plasma triglyceride and apolipoprotein B levels were correlated with 2-hour NEFA levels in each sex and ethnic group, and these associations were independent of glucose, insulin, and central obesity. These results are consistent with experimental studies of the effects of insulin and NEFAs on hepatic production of triglycerides and apolipoprotein B. Suppression of NEFA levels in response to insulin is greater in women than in men, and this may account for some of the sex differences in lipoprotein pattern and coronary heart disease risk. {Arteriosclerosis and Thrombosis 1993;13:1187-1192) KEY WORDS • triglyceride • apo B • insulin • fatty acids, nonesterified • obesity • sex factors • glucose T he higher coronary heart disease risk in men compared with women may be related to sex differences in lipoprotein pattern. 1 In comparison with women, men have higher levels of very-lowdensity lipoprotein (VLDL) triglyceride and apolipoprotein (apo) B, lower levels of high-density lipoprotein cholesterol (HDL-C), and a higher proportion of small, dense particles in the low-density lipoprotein (LDL) fraction. -4 The metabolic basis of these differences is poorly understood, although in both men and women HDL-C levels and LDL composition are closely dependent on plasma triglyceride levels. 56 Sex differences in the regulation of plasma triglyceride could thus account for some of the other sex differences in lipoprotein pattern.In a large population survey we demonstrated that elevated triglyceride levels and other metabolic disturbances associated with insulin resistance were more prevalent in people of South Asian (Indian, Pakistani, and Bangladeshi) descent than in Europeans, and that in both of these groups plasma triglyceride levels were higher in men than in women. 7 We also observed that the fall in plasma triglycerides in response to a glucose load was greater in women than in men: in Europeans the average change between fasting and 2 hours after loading was -6% in men and -16% in women, whereas in South Asians the average changes were -1% and -8%, respectively. 7Most triglycerides in plasma are carried in VLDL particles, which are produced in the liver and contain apoB. Elevation of VLDL triglyceride levels is closely related to an impairment in the ability of insulin to suppress nonesterified fatty acids (NEFAs), 89 which are the principal substrate for hepatic triglyceride synthesis. 10 We suggested that sex differences in the regulation of NEFA levels by insulin might thus account for the sex di...

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“…A brief summary of all studies published after 1987 is shown in Table 3. Studies before 1987, which in fact deal almost exclusively with those published before 1964, are not included as none of them took into account the fact that the level of fasting plasma triglycerides is such an important determinant of the evolution of postprandial plasma lipids after fat intake [109]. and B-100 Postprandial elevation of TRL ApoB-100 seems specifically associated with CAD + higher plasma triglycerides in the late postprandial phase or a generally elevated triglyceride curve (area under curve measurement) even after correction for the fasting level.…”

Section: Clinical Evidence For a Link Between Disturbed Metabolism Ofmentioning

confidence: 99%

Postprandial lipoprotein metabolism and atherosclerosis

Karpe

1999

Journal of Internal Medicine

361

242

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Relationship between Plasma Triglycerides and Removal of Chylomicrons*

Cited by 242 publications

References 12 publications

Alimentary lipemia-induced redistribution of cholesteryl ester between lipoproteins. Studies in normolipidemic, combined hyperlipidemic, and hypercholesterolemic men.

Alimentary lipemia-induced redistribution of cholesteryl ester between lipoproteins. Studies in normolipidemic, combined hyperlipidemic, and hypercholesterolemic men.

Relation of plasma triglyceride and apoB levels to insulin-mediated suppression of nonesterified fatty acids. Possible explanation for sex differences in lipoprotein pattern.

Postprandial lipoprotein metabolism and atherosclerosis

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