Relationship Between Plasma Neopterin and High Sensitivity C-Reactive Protein Levels and Circadian Rhythm of Blood Pressure in Hypertensive Patients with Obstructive Sleep Apnea Syndrome

Wang, Hai‐Ling; Cheng, Yun-dai; Wang, Yu; Zhang, Ying; Liu, Zhi-xuan; Liu, Qing-zeng; Tong, Haifeng; Xiao-jun, Wang; Yang, Mingyuan; Shi, Ke; Jing, Guoli

doi:10.1038/ajh.2012.78a

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They found no statistically significant difference between patients with and without OSA, but they found that neopterin levels were positively correlated with BMI [25]. In another study, plasma neopterin levels were found to be elevated in hypertensive patients with OSA and were positively correlated with the severity of OSA [26]. In this study the median value of neopterin measured in the severe group was significantly higher than the values measured in the control and mild-moderate groups (p<0.05; Table 2).…”

Section: Discussionmentioning

confidence: 94%

Serum neopterin, YKL-40, IL-6, and TNF-α in patients with obstructive sleep apnea

Admış,

Şahin,

Balbay

et al. 2023

Acta Medica

View full text Add to dashboard Cite

Objective: Obstructive Sleep Apnea (OSA) is characterized by recurrent episodes of complete or partial upper airway obstruction during sleep. The role of locally increased inflammation in the upper respiratory tract is known in the pathogenesis of OSA. This study aimed to examine the role of some inflammatory markers in OSA. Materials and Methods: Adult patients who underwent diagnostic polysomnography (PSG) for the first time, were evaluated in this prospective study. Serum levels of neopterin, human cartilage glycoprotein 39 (YKL-40), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were examined in the study group. Results: The study included 165 adult patients. Individuals of 56 who were did not have OSA were taken as the control group. Patients diagnosed with OSA (n=109) were included in the study and divided into two groups mild-moderate and severe based on the OSA apnea-hypopnea index (AHI). The study groups were divided into 3 cathegories: AHI <5 (control) Group 1, AHI 5-15 (mild), and AHI 15-30 (moderate) Group 2, AHI>30 (severe) Group 3. Individuals of 165 who completed the study [Group 1 (n=56), Group 2 (n=69), Group 3 (n=40)] were included in the statistical evaluation. There was a significant difference between the groups in terms of neopterin, YKL-40, and IL-6 values (p<0.05). The median value of IL-6 and neopterin measured in the severe group was significantly higher than the value measured in the control and mild-moderate groups (p<0.001). The mean value of YKL-40 measured in the severe group was significantly higher than the value measured in the control group (p=0.012). No significant difference was observed in TNF-α serum levels of groups. Conclusion: Serum levels of neopterin, YKL-40, and IL-6 were found to be elevated in OSA patients (especially in the severe group).

show abstract

Section: Discussionmentioning

confidence: 94%

Serum neopterin, YKL-40, IL-6, and TNF-α in patients with obstructive sleep apnea

Admış,

Şahin,

Balbay

et al. 2023

Acta Medica

View full text Add to dashboard Cite

show abstract

Increased neopterin concentration in patients with primary arterial hypertension

Cieślewicz

Korzeniowska

Bogdański

et al. 2015

JMS

View full text Add to dashboard Cite

The data on the safety profile of anti-tumor necrosis factor (anti-TNF) therapy in real-life patients cohorts with in flammatory bowel disease (IBD) still are lacking. Neopterin is a pteridine derivative produced from guanosine triphosphate mainly by activated monocytes and macrophages in response to cytokines produced by T-lymphocytes and natural killer cells. Changes in neopterin level reflect the stage of activation of cellular immune system and can be associated with various diseases. Low-grade inflammation is also an important factor in the pathophysiology of hypertension. In presented study we assessed neopterin concentration in 63 patients with primary arterial hypertension compared to 14 control healthy volunteers. Obtained results confirmed increased neopterin level in patients group.

show abstract

Relationship Between Plasma Neopterin and High Sensitivity C-Reactive Protein Levels and Circadian Rhythm of Blood Pressure in Hypertensive Patients with Obstructive Sleep Apnea Syndrome

Cited by 2 publications

References 0 publications

Serum neopterin, YKL-40, IL-6, and TNF-α in patients with obstructive sleep apnea

Serum neopterin, YKL-40, IL-6, and TNF-α in patients with obstructive sleep apnea

Increased neopterin concentration in patients with primary arterial hypertension

Contact Info

Product

Resources

About