Relationship between plasma levels and the anti-neuropathic pain effect of Lamotrigine in rat model

Pharmacological and neuroethological study of the acute and chronic effects of lamotrigine in the genetic audiogenic seizure hamster (GASH:Sal)

“…Its bioavailability was reported to be N90% [55,56], and the time required to reach its peak concentration in plasma following oral administration is 0.5-3 h [28,56]. The peak plasma concentrations of LTG in the GASH:Sal were observed approximately 60 min after parenteral drug administration, and LTG had an elimination half-life of 6 h, which is shorter than that recorded in guinea pigs (approximately 11.5 h) [57], albino rats (12 h) [58], and Sprague-Dawley rats (33.5 h) [28] but is comparable to the 120-240 min observed in CD-1 mice by Arban et al [59]. According to Patsalos et al [60], in patients with no comedication interaction, the half-life of LTG ranges from 15 to 35 h. We should take into account the possibility of more rapid elimination due to the low body weight of small animals and to various physiological and metabolic parameters, such as differences between the levels of metabolizing enzymes (CYPs) across species [61].…”