Relationship between plasma ghrelin levels and insulin resistance and blood pressure in octogenarians

Zhao, Yalei; Shao, Li; Teng, Lili; Dai-fu, Zhang; Zhang, Hua

doi:10.1007/s11596-010-0347-2

Cited by 4 publications

(1 citation statement)

References 37 publications

(32 reference statements)

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“…Our data shows that ghrelin negatively correlated with SBP and DBP in Arab Females. Several studies looked at the effect of intravenous injection of human ghrelin on BP and heart rate [ 25 , 31 – 34 ]. For example, Nagaya et al showed that intravenous injection of ghrelin caused a long-lasting GH release as well as favorable hemodynamic effects causing a decrease in resistance of peripheral artery that ultimately caused a drop in BP without increasing heart rate [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population

Abu‐Farha

Dehbi

Noronha

et al. 2014

International Journal of Endocrinology

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Ghrelin is a stomach produced hormone that has been shown to have protective role against development of CVD which is a leading cause of death in the Arab world. The objective of this study is to examine the gender difference in association between traditional CVD risk factors and plasma ghrelin among Arabs. 359 Arab residents in Kuwait participated in a cross-sectional survey (≥20 years old): 191 were females and 168 were males. Plasma level of ghrelin was assessed using Luminex-based assay. Ghrelin levels were significantly higher in females (935 ± 78 pg/mL) than males (763 ± 65 pg/mL) (P = 0.0007). Females showed inverse association with WC (r = −0.23, P = 0.001) and HbA1C (r = −0.19, P = 0.0102) as well as SBP (r = −0.15, P = 0.0383) and DBP (r = −0.16, P = 0.0230), respectively. Higher levels of ghrelin were shown to associate with increased insulin resistance, as measured by HOMAIR, in male Arab subjects (P-trend = 0.0202) but not in females. In this study we show that higher ghrelin level was negatively associated with measures of obesity, HbA1C, and blood pressure in females and positively associated with increased insulin resistance in Arab males.

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Section: Discussionmentioning

confidence: 99%

Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population

Abu‐Farha

Dehbi

Noronha

et al. 2014

International Journal of Endocrinology

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Circulating Obestatin Levels Correlate with Fasting Insulin and HOMA-IR but Not with Hypertension in Elderly Men

Shao

Zhao

Teng

et al. 2013

Cell Biochem Biophys

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Obestatin, encoded by the same gene as ghrelin, was first described as a physiological opponent of ghrelin. The association between circulating obestatin levels and blood pressure remains unclear. Furthermore, adequate information is non-existent regarding the older male population with hypertension. For this purpose, we enrolled 185 unrelated hypertensive male patients aged ≥ 80 years (range 80-102 years). One hundred seventy nine age-matched healthy subjects served as controls. Plasma levels of obestatin and insulin were measured using commercial ELISA and RIA. HOMA-IR was calculated using standard method. We found that plasma obestatin levels correlated significantly with insulin levels (P = 0.034) and homeostasis model assessment index for insulin resistance (HOMA-IR: P = 0.028). However, plasma obestatin differed non-significantly between hypertensive (5.06 ± 0.68 ng/mL) and non-hypertensive (4.72 ± 0.82 ng/mL) individuals. Plasma obestatin levels were not associated with systolic (P = 0.818) or diastolic (P = 0.564) blood pressure, waist-to-hip ratio (WHR: P = 0.725), uric acid (P = 0.603), total cholesterol (TC: P = 0.589), low-density lipoprotein cholesterol (LDL-C: P = 0.057); high-density lipoprotein cholesterol (HDL-C: P = 0.432), triglyceride (TG: P = 0.418), and fasting blood glucose (FBG: P = 0.101). We, therefore, concluded that fasting circulating obestatin levels did not directly correlate with blood pressure in men aged ≥ 80 years.

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Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress

Spencer

Clarke

et al. 2012

Biological Psychiatry

213

177

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Relationship between plasma ghrelin levels and insulin resistance and blood pressure in octogenarians

Cited by 4 publications

References 37 publications

Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population

Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population

Circulating Obestatin Levels Correlate with Fasting Insulin and HOMA-IR but Not with Hypertension in Elderly Men

Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress

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