Relationship between plasma asymmetric dimethylarginine level and autonomic dysfunction in diabetic patients

Akyel, Ahmet; Çengel, Atiye; Tavıl, Yusuf; Şahinarslan, Asife; Topal, Salih; Yayla, Çağrı; Elbeğ, Şehri; Boyacı, Bülent; Arslan, Metin

doi:10.5543/tkda.2012.01826

Cited by 4 publications

(19 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Five studies assessed the influence of high blood pressure on HRV in T2DM compared with healthy controls [49,50,54,55,58]. Other studies compared HRV between T2DM patients and controls based on blood catecholamine levels [44], circadian autonomic rhythm in insulinoresistant subjects [45], in cases of bowel preparation [63], metabolic syndrome [47], circadian rhythm in relation to blood adiponectin [62], or dimethylarginine levels [61], hypoglycaemic episodes [59], in acromegalic patients [53], and inhalation of ultrafine particles [57].…”

Section: Objectives Of Included Articlesmentioning

confidence: 99%

“…In each individual study, exclusion criteria were the same as for T2DM, i.e. pregnancy [43,62], neurological disease [43], BMI over 25 kg/m 2 [42,44,45] or 35 kg/m 2 [58,62], chronic heart [42,44,45,[50][51][52]57,58,[60][61][62][63], liver [56,60,63], or renal [42,42,45,56,58,[60][61][62][63] failure, thyroid disorder [50,52], or treatment that can influence HRV parameters [44][45][46]52,54,[57][58][59][60]. Controls had high blood pressure in five studies [49,56,58,60,62], and were on dialysis in three studies [43,…”

Section: Inclusions and Exclusions Criteriamentioning

confidence: 99%

“…The mean HbA1c in T2DM patients was 7.6±0.8%, ranging from 6.5 [59] to 9.3% [58,62], and 5.2±0.5% in the controls, ranging from 4.1 [42] to 5.8% [58,62]. Eight studies did not report HbA1c in the T2DM patients [43,45,46,48,50,53,61,64] and nine studies did not specify for the controls [43,[45][46][47][48]50,53,61,64]. Blood glucose levels were reported in 14 studies [42,44,46,47,51,52,55,58,[60][61][62][63]65,66] with a mean blood glucose level of 147±16 mg/ dL in T2DM patients, ranging from 117 [47] to 168 [58,62], and 90±6 in controls, ranging from 75 [46] to 95 [55].…”

Section: Populationmentioning

confidence: 99%

“…Weight was reported in three studies [43,46,49], and waist circumference in two studies [47,52]. The mean BMI in T2DM patients was 27.2±3.5 kg/m 2 , ranging from 22.3 [44] to 33.7 [58,62], and 24.8±2.1 in controls, ranging from 21.8 [61] to 29.7 [54]. BMI was not reported in 11 studies in T2DM patients [42,43,46,48,[50][51][52][53]55,57,64], and in 12 studies in controls [42,43,46,48,[50][51][52][53]55,57,59,64].…”

Section: Populationmentioning

confidence: 99%

See 3 more Smart Citations

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Benichou

Pereira

Mermillod

et al. 2018

Annales d'Endocrinologie

View full text Add to dashboard Cite

BackgroundCardiac autonomic neuropathy in type 2 dibetes mellitus (T2DM) patients is frequent and associated with high cardiovascular mortality. Heart rate variability (HRV) is the gold standard to measure cardiac autonomic neuropathy. We aimed to conduct a systematic review and meta-analysis to evaluate the impact of T2DM on HRV parameters. OPEN ACCESS Citation: Benichou T, Pereira B, Mermillod M, Tauveron I, Pfabigan D, Maqdasy S, et al. (2018) Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis. PLoS ONE 13(4): e0195166. https://doi.org/10.-2.13 to -0.91), lower LF (-1.08; -1.46 to -0.69]), and lower HF (-0.79; -1.09 to -0.50). LF/HF did not differ between groups. Levels of blood glucose and HbA1c were associated with several HRV parameters, as well as Time from diagnosis of T2DM ConclusionsT2DM was associated with an overall decrease in the HRV of T2DM patients. Both sympathetic and parasympathetic activity were decreased, which can be explained by the deleterious effects of altered glucose metabolism on HRV, leading to cardiac autonomic neuropathy.

show abstract

Section: Objectives Of Included Articlesmentioning

confidence: 99%

Section: Inclusions and Exclusions Criteriamentioning

confidence: 99%

Section: Populationmentioning

confidence: 99%

Section: Populationmentioning

confidence: 99%

See 2 more Smart Citations

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Benichou

Pereira

Mermillod

et al. 2018

Annales d'Endocrinologie

View full text Add to dashboard Cite

show abstract

“…The abnormal glucose metabolism due to DM may induce cardiomyopathy and lead to changes on the echocardiography (ECG). In previous research, the effects of DM on ECG were concentrated in heart rate variability, [1][2][3][4][5][6] RR interval, 6 T-wave alternans, 7 QTc interval, [8][9][10] and ST segment, 11 which are predictive of cardiac mortality and diagnosis of silent myocardial infarction in DM. Recent reports showed that the maximal magnitude of frontal QRS-T angle (FQRSTA) was significantly associated with the prognosis of elderly patients, 12 myocardial infarction, [13][14][15][16][17] heart failure, 17 and chronic dialysis.…”

mentioning

confidence: 99%

Changes of Virtual Planar QRS and T Vectors Derived from Holter in the Populations with and without Diabetes Mellitus

Chen

Lin

et al. 2015

Ann Noninvasive Electrocardiol

View full text Add to dashboard Cite

Aims: Research related to type 2 diabetes mellitus (DM) and parameters of electrocardiography (ECG) was limited. Patients with and without DM (NDM) were randomly enrolled in a study to exploit the influence of DM on planar QRS and T vectors derived from the Virtual Holter process.Methods: A total of 216 (NDM) and 127 DM patients were consecutively and randomly recruited. We selected a 1-minute length of ECG, which was scheduled for analysis at 4 AM. After a series of calculating algorisms, we received the virtual planar vector parameters.Results: Patients with DM were elderly (65.61 ± 12.08 vs 59.41 ± 16.86 years, P < 0.001); higher morbidity of hypertension (76.38% vs 58.14%, P < 0.001) and coronary artery disease (44.09% vs 32.41%, P = 0.03); thicker interventricular septum (10.92 ± 1.77 vs 10.08 ± 1.96 mm, P < 0.001) and left ventricular posterior wall (9.84 ± 1.38 vs 9.39 ± 1.66 mm, P = 0.03); higher lipid levels and average heart rate (66.67 ± 12.04 vs 61.87 ± 13.36 bpm, P < 0.01); higher angle of horizontal QRS vector (HQRSA, -2.87 ± 48.48 vs -19.00 ± 40.18 degrees, P < 0.01); lower maximal magnitude of horizontal T vector (HTV, 2.33 ± 1.47 vs 2.88 ± 1.89 mm, P = 0.01) and maximal magnitude of right side T vector (2.77 ± 1.55 vs 3.27 ± 1.92 mm, P = 0.03), and no difference in angle of frontal QRS-T vector (FQRSTA, 32.77 ± 54.20 vs 28.39 ± 52.87 degrees, P = 0.74) compared with patients having NDM. After adjusting for confounding factors, DM was significantly effective on FQRSTA (regression coefficient -40.0, 95%CI -66.4 to -13.6, P < 0.01), HQRSA (regression coefficient 22.6, 95%CI 2.5 to 42.8, P = 0.03), and HTV (regression coefficient 0.9, 95%CI 0.2 to 1.7, P = 0.01). Confounding

show abstract

Comparision of Effects of Rosuvastatin Versus Atorvastatin Treatment on Plasma Levels of Asymmetric Dimethylarginine in Patients With Hyperlipidemia Having Coronary Artery Disease

Kurtoğlu

Balta

Sıncer³

et al. 2013

Angiology

View full text Add to dashboard Cite

Elevated plasma levels of asymmetric dimethylarginine (ADMA) are prevalent in patients with hypercholesterolemia and coronary artery disease. A total of 83 patients with hypercholesterolemia and angiographically documented mild coronary artery stenosis were randomized to rosuvastatin treatment (20 mg) or atorvastatin treatment (40 mg) once daily for 6 weeks after a 4-week dietary lead-in phase. Both statins decreased total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride levels effectively. Only rosuvastatin increased high-density lipoprotein cholesterol (HDL-C) levels. Both rosuvastatin and atorvastatin decreased plasma ADMA levels; rosuvastatin had a significantly greater effect. The reduction in ADMA levels were correlated with the reduction in TC and LDL-C levels as well as LDL-C-HDL-C ratio. Treatment with rosuvastatin or atorvastatin in patients with hyperlipidemia with mild coronary artery stenosis may lead to a decrease in ADMA levels, which may contribute to improved endothelial function.

show abstract

Relationship between plasma asymmetric dimethylarginine level and autonomic dysfunction in diabetic patients

Abstract: Our findings show that plasma ADMA levels are increased and HRV is reduced in diabetic patients, indicating that these patients have both endothelial dysfunction and autonomic dysfunction, but plasma ADMA levels cannot be used to evaluate autonomic dysfunction.

Cited by 4 publications

References 21 publications

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Changes of Virtual Planar QRS and T Vectors Derived from Holter in the Populations with and without Diabetes Mellitus

Comparision of Effects of Rosuvastatin Versus Atorvastatin Treatment on Plasma Levels of Asymmetric Dimethylarginine in Patients With Hyperlipidemia Having Coronary Artery Disease

Contact Info

Product

Resources

About