Relationship between plasma adrenomedullin levels and metabolic control, risk factors, and diabetic microangiopathy in patients with type 2 diabetes.

Türk, Hacı Mehmet; Buyukberber, S; Sevinç, Alper; Ak, Gupta; Ateş, Mahmut; Sári, Réka; Şavlı, Haluk; Çığlı, Ahmet

doi:10.2337/diacare.23.6.864a

Cited by 22 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, whether or not the presence of diabetic microangiopathy resulted in elevation in adrenomedullin levels was also controversial. Nakamura et al (9) suggested that increment in plasma adrenomedullin was dependent on the severity of diabetic nephropathy, whereas other investigators reported otherwise (7).…”

mentioning

confidence: 78%

“…In vitro data suggested that hyperglycemia might increase vascular adrenomedullin expression (10). However, this notion could not be substantiated in vivo (7,8). Other postulated mechanisms included acute hyperinsulinemia (28), increased oxidative stress (based on in vivo studies) (29), and proatherogenic/ inflammatory factors such as angiotensin II, endothelin-1 (30), interleukin-1␤, and tumor necrosis factor-␣ (31) (based on cell culture studies).…”

Section: Measurement Of Forearm Cutaneous Microcirculatory Functionmentioning

confidence: 99%

“…Animal model research revealed that hyperglycemia increased vascular adrenomedullin expression (10). Other studies, however, cannot find any relationship between plasma adrenomedullin concentrations and the degree of metabolic control or risk factors traditionally associated with endothelial injury (e.g., hypertension and dyslipidemia) (7,8). These studies were typically conducted among small numbers of subjects in whom potential confounders (e.g., therapeutic agents) were unaccounted.…”

mentioning

confidence: 99%

“…Preliminary studies on small numbers of type 2 diabetic subjects reported inconsistent results. Turk et al (7) showed that type 2 diabetes was associated with significant elevation in plasma adrenomedullin levels. However, this finding was not replicated by another study, which demonstrated no difference in plasma adrenomedullin levels between diabetic patients and control subjects (8).…”

mentioning

confidence: 99%

See 3 more Smart Citations

The Relationship Between Adrenomedullin, Metabolic Factors, and Vascular Function in Individuals With Type 2 Diabetes

Lim

Morgenthaler²,

Tavintharan

et al. 2007

Diabetes Care

View full text Add to dashboard Cite

CHEE FANG SUM, MBBS1 OBJECTIVE -Subjects with type 2 diabetes are at risk for vascular injury. Several vasoactive factors (e.g., angiotensin) have been implicated. We hypothesize that adrenomedullin, a novel vascoactive factor, is deranged in subjects with type 2 diabetes.RESEARCH DESIGN AND METHODS -Using a new immunoluminometric method, plasma midregional proadrenomedullin (MR-proADM) was measured in four groups of Chinese subjects: healthy (n ϭ 100, fasting plasma glucose [FPG] Ͻ5.6 mmol/l), impaired fasting glucose (IFG) (n ϭ 60, FPG 5.6 -6.9 mmol/l), and diabetic subjects with (n ϭ 100) and without (n ϭ 100) nephropathy. Resting forearm cutaneous microcirculatory perfusion (RCMP) was quantified in vivo using 2-dimensional laser Doppler flowmetry. We investigated the relationship between plasma MR-proADM concentrations, multiple metabolic factors, and vascular function.RESULTS -We observed a stepwise increase in MR-proADM among the groups: healthy group mean Ϯ SD 0.27 Ϯ 0.09, IFG group 0.29 Ϯ 0.13, diabetic group 0.42 Ϯ 0.13, and diabetic nephropathy group 0.81 Ϯ 0.54 nmol/l (diabetic vs. healthy and IFG groups, P ϭ 0.04; and diabetic nephropathy group vs. all, P Ͻ 0.01). Statistical adjustment for sex, age, BMI, and blood pressure did not affect the conclusions. Multiple linear regression analysis revealed that highly sensitive C-reactive protein (␤ ϭ 0.11; P ϭ 0.01), insulin resistance index (␤ ϭ 0.20; P ϭ 0.001), LDL cholesterol (␤ ϭ 0.31; P Ͻ 0.001), and adiponectin (␤ ϭ 0.33; P Ͻ 0.001) were significant predictors of plasma MR-proADM concentrations among nondiabetic individuals. Among subjects with diabetes, plasma MR-proADM concentrations correlated significantly with RCMP (r ϭ 0.43, P ϭ 0.002).CONCLUSIONS -Plasma MR-proADM concentration was elevated in subjects with type 2 diabetes. This was further accentuated when nephropathy set in. MR-proADM was related to multiple metabolic factors and basal microcirculatory perfusion. Adrenomedullin might play a role in the pathogenesis of diabetic vasculopathy. Diabetes Care 30:1513-1519, 2007I ndividuals with type 2 diabetes are at risk for vascular injury. Although major advances have been made in uncovering the mechanism of diabetic vasculopathy, the exact pathophysiology remains incompletely understood (1). In recent years, the importance of endothelial dysfunction has taken central stage (2). By secreting a repertoire of finely regulated vasoactive factors with opposing functions working in autocrine and paracrine fashion, the endothelium is pivotal in maintaining vascular homeostasis (3). Numerous vascoactive factors have been described. Among these factors, adrenomedullin, a 52-amino acid peptide, has been intensively investigated due to its vascular protective properties (e.g., vasodilatory and antiproliferative) and promising potential as a therapeutic target (4). However, understanding of the pathobiology of adrenomedullin in diabetic vasculopathy has only just begun.In healthy states, adrenomedullin circulates at low picomolar concentration, which i...

show abstract

mentioning

confidence: 78%

Section: Measurement Of Forearm Cutaneous Microcirculatory Functionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

The Relationship Between Adrenomedullin, Metabolic Factors, and Vascular Function in Individuals With Type 2 Diabetes

Lim

Morgenthaler²,

Tavintharan

et al. 2007

Diabetes Care

View full text Add to dashboard Cite

show abstract

“…ADM is an adipokine (3) and is expressed in many different tissues, including adipose tissue, adrenal medulla, lung, heart, and kidney (1)(2)(3)(4). Its plasma level is elevated in obesity (5-7), hypertension (8,9), renal failure (8,9), type 2 diabetes (10)(11)(12), and congestive heart failure (8,13). ADM also plays an important regulatory role in both acute and chronic inflammation (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene

Cheung

Ong²,

Tso³

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Adrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers. Design and methods: Plasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped. Results: Plasma ADM level increased with decreasing plasma IL6 level (bZK0.116, PZ0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (PZ0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5-17.8%) lower than the non-carriers (bZK0.115, PZ0.011). Haplotype analysis revealed a similar significant association with plasma ADM (PZ0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (PZ0.010). Conclusion: Plasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction.

show abstract

Adrenomedullin and diabetes mellitus

Ruzicska

Tóth

Tulassay

et al. 2001

Diabetes Metabolism Res

View full text Add to dashboard Cite

Adrenomedullin (AM) is a novel 52 amino acid peptide hormone, originally isolated from human pheochromocytoma. AM acts as a local autocrine and/or paracrine vasoactive hormone and has vasodilator and blood pressure lowering properties. AM as a vasodilative molecule protects the vascular wall but its exact role is still uncertain. AM is considered to play an important endocrine role in various tissues in maintaining electrolyte and fluid homeostasis. Its plasma concentration in healthy conditions is low. In hypertension, chronic renal failure and congestive heart failure its plasma concentration increases in a parallel manner with the severity of the disease. It is assumed that this peptide plays an important role in physiological and pathological conditions compensating the effects of vasoconstrictive molecules. Investigations have proven that in diabetic angiopathies the levels and production of vasoconstrictive factors and AM are increased, while other relaxing substances such as nitric oxide (NO) are decreased. It is still uncertain whether the increased release of AM is a compensatory mechanism or a coincidental event. Although the precise role of AM in the pathogenesis of diabetic complications is still to be elucidated, the altered concentration of AM in diabetes could indicate a certain interaction between AM induction and vascular function. Hence, the induction of vascular AM can be a new target of therapeutic approach to diabetic complications.

show abstract

Relationship between plasma adrenomedullin levels and metabolic control, risk factors, and diabetic microangiopathy in patients with type 2 diabetes.

Abstract: Sane , Saito H: Endogenous glucose production and glucose effectiveness in type 2 diabetic subjects derived from stablelabeled minimal model approach.

Cited by 22 publications

References 0 publications

The Relationship Between Adrenomedullin, Metabolic Factors, and Vascular Function in Individuals With Type 2 Diabetes

The Relationship Between Adrenomedullin, Metabolic Factors, and Vascular Function in Individuals With Type 2 Diabetes

Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene

Adrenomedullin and diabetes mellitus

Contact Info

Product

Resources

About