Relationship Between Peritoneal Collagen Type IV Concentrations and the Presence of Disseminated Metastases in Gastric Cancer

Korenaga, Daisuke; Funahashi, Satoru; Yano, Kazuhiro; Maekawa, Soichiro; Ikeda, Toshihiko; Sugimachi, Keizō

doi:10.1001/archsurg.1995.01430070091018

Cited by 7 publications

(7 citation statements)

References 10 publications

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“…3F), and these ECM proteins were certainly involved in the spheroids that were recovered from the peritoneal cavity (Fig. 3F), results that explain very well the clinical findings previously reported by our laboratory (17).…”

Section: Cxcr4-dependent Tumor Metastasis To the Mesentery Is Directisupporting

confidence: 87%

Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation

et al. 2016

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Peritonitis carcinomatosa is an advanced and intractable state of gastrointestinal and ovarian cancer, where mechanistic elucidation might enable the development of more effective therapies. Peritoneal dissemination of this type of malignancy has been generally thought to initiate from "milky spots" of primitive lymphoid tissues in the peritoneal cavity. In this study, we offer evidence challenging this idea, based on the finding that tumor implantation and directional dissemination was not required for the presence of milky spots, but rather SCF/CXCL12-expressing niche-like cells located at the border regions of perivascular adipose tissue. Interestingly, we found that peritoneal cavity lavage fluid, which specifically contains peritoneal collagen type IV and plasma fibronectin, dramatically facilitated spheroid formation of murine and human colon cancer cells. Spheroid formation strongly induced the expression of CXCR4 in an Sp1-dependent manner to promote niche-directed metastasis. Notably, disrupting sphere formation or inhibiting Sp1 activity was sufficient to suppress tumor dissemination and potentiated chemosensitivity to 5-fluorouracil. Our findings illuminate mechanisms of peritoneal cancer dissemination and highlight the Sp1/CXCR4/CXCL12 signaling axis as a rational target for the development of therapeutics to manage this intractable form of malignancy. Cancer Res; 76(2); 347-57. Ó2016 AACR.

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Section: Cxcr4-dependent Tumor Metastasis To the Mesentery Is Directisupporting

confidence: 87%

Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation

et al. 2016

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“…Serum CEA level is a common preoperative and follow-up marker of gastrointestinal tumours (Holyoke et al, 1975;Korenaga et al, 1995). Serum CEA is a useful indicator of potential curability in patients who undergo gastrectomy and it provides predictive value in determining tumour stage and prognostic information for patients with potentially resectable gastric cancer Tachibana et al, 1998;Kochi et al, 2000).…”

Section: Second-line Chemotherapy In Metastatic Gastric Cancer V Catamentioning

confidence: 99%

Second-line chemotherapy for patients with advanced gastric cancer: who may benefit?

et al. 2008

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No established second-line chemotherapy is available for patients with advanced gastric cancer failing to respond or progressing to first-line chemotherapy. However, 20 -40% of these patients commonly receive second-line chemotherapy. We evaluated the influence of clinico-pathologic factors on the survival of 175 advanced gastric cancer patients, who received second-line chemotherapy at three oncology departments. Univariate and multivariate analyses found five factors which were independently associated with poor overall survival: performance status 2 (hazard ratio (HR), 1.79; 95% CI, 1.16 -2.77; P ¼ 0.008), haemoglobin p11.5 g l À1 (HR, 1.48; 95% CI, 1.06 -2.05; P ¼ 0.019), CEA level 450 ng ml À1 (HR, 1.86; 95% CI, 1.21 -2.88; P ¼ 0.004), the presence of greater than or equal to three metastatic sites of disease (HR, 1.72; 95% CI, 1.16 -2.53; P ¼ 0.006), and time-toprogression under first-line chemotherapy p6 months (HR, 1.97; 95% CI, 1.39 -2.80; Po0.0001). A prognostic index was constructed dividing patients into low-(no risk factor), intermediate-(one to two risk factors), or high-(three to five risk factors) risk groups, and median survival times for each group were 12.7 months, 7.1 months, and 3.3 months, respectively (Po0.001). In the absence of data deriving from randomised trials, this analysis suggests that some easily available clinical factors may help to select patients with advanced gastric cancer who could derive more benefit from second-line chemotherapy.

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“…CEA is generally accepted as a specific marker of gastrointestinal tumor [20,21] . Recently, measurement of CEA level and CEA RT-PCR assay in peritoneal washes have been used to detect the existence of free cancer cells in the peritoneal cavity [10,22,23] .…”

Section: Discussionmentioning

confidence: 99%

Peritoneal lavage cytology and carcinoembryonic antigen determination in predicting peritoneal metastasis and prognosis of gastric cancer

Zheng²,

Chuanwen³

et al. 2005

WJG

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AIM:To evaluate the role of peritoneal lavage cytology (PLC) and carcinoembryonic antigen (CEA) determination of peritoneal washes (pCEA) in predicting the peritoneal metastasis and prognosis after curative resection of gastric cancer. METHODS:PLC and radioimmunoassay of CEA were performed in peritoneal washes from 64 patients with gastric cancer and 8 patients with benign diseases. RESULTS:The positive rate of pCEA (40.6%) was significantly higher than that of PLC (23.4%) (P <0.05). The positive rates of PLC and pCEA correlated with the depth of tumor invasion and lymph node metastasis (P <0.05). pCEA was found to have a higher sensitivity and a lower false-positive rate in predicting peritoneal metastasis after curative resection of gastric cancer as compared to PLC. The 1-, 3-, and 5-year survival rates of patients with positive cytologic findings or positive pCEA results were significantly lower than those of patients with negative cytologic findings or negative pCEA results (P <0.05). Multivariate analysis indicated that pCEA was an independent prognostic factor for the survival of patients with gastric cancer. CONCLUSION:Intraoperative pCEA is a more sensitive and reliable predictor of peritoneal metastasis as well as prognosis in patients with gastric cancer as compared to PLC method.

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Relationship Between Peritoneal Collagen Type IV Concentrations and the Presence of Disseminated Metastases in Gastric Cancer

Abstract: Quantitative detection of abnormal collagen type IV levels may be useful for predicting the presence of disseminated metastases in patients with gastric cancer.

Cited by 7 publications

References 10 publications

Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation

Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation

Second-line chemotherapy for patients with advanced gastric cancer: who may benefit?

Peritoneal lavage cytology and carcinoembryonic antigen determination in predicting peritoneal metastasis and prognosis of gastric cancer

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