Relationship between Peripheral Blood miR-181c, miR-101, and Cognitive Impairment in Patients with Diabetes Mellitus Complicated with Acute Stroke

Abstract

Objectives. To explore the relationship between peripheral blood microRNA-181c (miR-181c), microRNA-101 (miR-101), and cognitive impairment (CI) in patients with diabetes mellitus (DM) complicated with acute stroke (AS). Methods. A retrospective analysis was performed on 70 patients with DM complicated with AS admitted to the hospital between January 2019 and December 2021. According to presence or absence of CI, they were divided into CI group (41 cases) and non-CI group (29 cases). The clinical characteristics and general data (blood glucose and blood lipid) of patients were statistically analyzed. The relative expression levels of miR-181c and miR-101 in peripheral blood were detected by real-time fluorescence quantitative PCR. The risk factors of CI were analyzed by logistic regression analysis. The diagnostic value of peripheral blood miR-181c and miR-101 for CI was evaluated by receiver operating characteristic (ROC) curves. Results. The relative expression levels of peripheral blood miR-181c and miR-101 in the CI group were lower than those in the non-CI group ( P < 0.05 ). The occurrence of CI was related to age, course of DM, AS location, time from onset to admission, HbA1c, TG, UA, and Hcy levels ( P < 0.05 ). Logistic regression analysis showed that age, AS location, HbA1c, miR-181c, and miR-101 were related influencing factors of CI in patients with DM complicated with AS ( P < 0.05 ). The results of ROC curves analysis showed that AUC, sensitivity, and specificity of miR-181c combined with miR-101 for predicting CI were 0.865, 73.17%, and 89.66%, respectively ( P < 0.05 ). Conclusions. The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS. Besides, the combined detection of miR-181c and miR-101 expression has a good diagnostic value for CI.

MicroRNA‐181 in cardiovascular disease: Emerging biomarkers and therapeutic targets

“…65 Furthermore, miR-181 has been linked to diabetic cardiovascular complications. [66][67][68][69] Hydrogen peroxide (H 2 O 2 ) markedly increased miR-181a expression in the H9C2 rat cardiomyocytes and regulated the mitochondrial apoptotic pathway by targeting glutathione peroxidase-1 (GPx1), a pivotal intracellular antioxidant enzyme. 70 MiR-181a-5p was involved in hypoxia-reoxygenation-induced cardiomyocyte apoptosis by targeting sirtuin 1 (SIRT1).…”

“…examined the expression of peripheral blood miRNAs in young healthy controls, aged healthy controls, and age‐matched HF patients and reported that miR‐181 family members' expression was reduced in aged individuals and further reduced in age‐matched HF patients 65 . Furthermore, miR‐181 has been linked to diabetic cardiovascular complications 66–69 . Hydrogen peroxide (H 2 O 2 ) markedly increased miR‐181a expression in the H9C2 rat cardiomyocytes and regulated the mitochondrial apoptotic pathway by targeting glutathione peroxidase‐1 (GPx1), a pivotal intracellular antioxidant enzyme 70 .…”

Retracted: Relationship between Peripheral Blood miR-181c, miR-101, and Cognitive Impairment in Patients with Diabetes Mellitus Complicated with Acute Stroke

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…Tis article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”