Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth—a cross-sectional study in a Japanese population

Matsuda, Shinji; Okanobu, Ai; Hatano, Saki; Kajiya, Mikihito; Sasaki, Susumu; Hamamoto, Yuta; Iwata, Takeo; Ouhara, Kazuhisa; Takeda, Katsuhiro; Mizuno, Noriyoshi; Fujita, Tsuyoshi; Kurihara, Hidemi

doi:10.1007/s00784-019-02846-8

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…Many studies have used PISA for evaluation of periodontal conditions. Since PISA reflects the inflammation status of periodontal tissue, these studies focused on the correlation of PISA and systemic diseases [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43], or the correlation of PISA with novel disease markers [41][42][43][44][45][46][47][48]. In the present study, IRT analysis was used to set a cut-off point for the number of bleeding sites and the maximum values of PD in a single tooth.…”

Section: Discussionmentioning

confidence: 99%

Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination

Nomura

Morozumi

Numabe

et al. 2021

JCM

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The periodontal inflamed surface area (PISA) is a useful index for clinical and epidemiological assessments, since it can represent the inflammation status of patients in one contentious variable. However, calculation of the PISA is difficult, requiring six point probing depth measurements with or without bleeding on probing on 28 teeth, followed by data input in a calculation program. More simple methods are essential for screening periodontal disease or in epidemiological studies. In this study, we tried to establish a convenient partial examination method to estimate PISA. Cross-sectional data of 254 subjects who completed active periodontal therapy were analyzed. Teeth that represent the PISA value were selected by an item response theory approach. The maxillary second molar, first premolar, and lateral incisor and the mandibular second molar and lateral incisor were selected. The sum of the PISAs of these teeth was significantly correlated with the patient’s PISA (R2 = 0.938). More simply, the sum of the maximum values of probing pocket depth with bleeding for these teeth were also significantly correlated with the patient’s PISA (R2 = 0.6457). The simple model presented in this study may be useful to estimate PISA.

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Section: Discussionmentioning

confidence: 99%

Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination

Nomura

Morozumi

Numabe

et al. 2021

JCM

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“…2 Gingivitis triggers the release of cytokines, leading to fibroblast cell proliferation and a subsequent increase in collagen synthesis. 12 Amlodipine simply amplifies this existing pathway by accelerating matrix buildup and inhibiting matrix breakdown. 28 Studies suggest sex plays a role in the development of AIGO because males are more susceptible than females.…”

Section: Risk Factorsmentioning

confidence: 99%

“…In the last 4 years alone, there have been over 17 published case studies describing AIGO. 2,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] In addition to case reports, research also indicates that the prevalence of AIGO may be greater than 1%. Some studies suggest that the prevalence of AIGO is only slightly more common than drug reference guides suggest (ie, < 1%).…”

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confidence: 99%

Amlodipine-Induced Gingival Overgrowth: A Health Justice Issue

Portnoy¹,

Lee²,

McMullen³

et al. 2022

The Journal for Nurse Practitioners

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“…We and other investigators previously reported a role for periodontal inflammation in the development of DIGO in clinical studies 13‐16 and in vivo and in vitro studies 17‐19 . We recently developed a novel DIGO mouse model induced by ligature‐induced periodontitis with the application of CsA, in which the expansion of gingival tissue is excessive 19 …”

Section: Introductionmentioning

confidence: 99%

The role of nuclear receptor 4A1 (NR4A1) in drug‐induced gingival overgrowth

et al. 2021

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Drug‐induced gingival overgrowth (DIGO) is a side effect of cyclosporine A (CsA), nifedipine (NIF), and phenytoin (PHT). Nuclear receptor 4A1 (NR4A1) plays a role in fibrosis in multiple organs. However, the relationship between NR4A1 and DIGO remains unclear. We herein investigated the involvement of NR4A1 in DIGO. In the DIGO mouse model, CsA inhibited the up‐regulation of Nr4a1 expression induced by periodontal disease (PD) in gingival tissue, but not that of Col1a1 and Pai1. We detected gingival overgrowth (GO) in Nr4a1 knock out (KO) mice with PD. A NR4A1 agonist inhibited the development of GO in DIGO model mice. TGF‐β increased Col1a1 and Pai1 expression levels in KO mouse gingival fibroblasts (mGF) than in wild‐type mice, while the overexpression of NR4A1 in KO mGF suppressed the levels. NR4A1 expression levels in gingival tissue were significantly lower in DIGO patients than in PD patients. We also investigated the relationship between nuclear factor of activated T cells (NFAT) and NR4A1. NFATc3 siRNA suppressed the TGF‐β‐induced up‐regulation of NR4A1 mRNA expression in human gingival fibroblasts (hGF). CsA suppressed the TGF‐β‐induced translocation of NFATc3 into the nuclei of hGF. Furthermore, NIF and PHT also decreased NR4A1 mRNA expression levels and suppressed the translocation of NFATc3 in hGF. We confirmed that CsA, NIF, and PHT reduced cytosolic calcium levels increased by TGF‐β, while CaCl2 enhanced the TGF‐β‐up‐regulated NR4A1 expression. We propose that the suppression of the calcium‐NFATc3‐NR4A1 cascade by these three drugs plays a role in the development of DIGO.

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Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth—a cross-sectional study in a Japanese population

Cited by 7 publications

References 25 publications

Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination

Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination

Amlodipine-Induced Gingival Overgrowth: A Health Justice Issue

The role of nuclear receptor 4A1 (NR4A1) in drug‐induced gingival overgrowth

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