Relationship Between Periodontal Disease and C-Reactive Protein Among Adults in the Atherosclerosis Risk in Communities Study

Slade, Gary D.; Ghezzi, Elisa M.; Heiss, Gerardo; Beck, James D.; Riche, Estelle; Offenbacher, Steven

doi:10.1001/archinte.163.10.1172

Cited by 273 publications

(140 citation statements)

References 31 publications

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“…In addition, the results from this study and other reports findings that also showed a relationship between C-reactive protein and periodontal disease 14,24,25 suggesting that this relationship could be of public health relevance. For example, if one of the objectives of a weight reduction program is to reduce a proinflammatory state then evaluation of the patient's periodontal status is important to effectively reduce hs-CRP levels.…”

Section: Discussionsupporting

confidence: 75%

“…Results of several randomized clinical trials corroborate the current view that periodontal treatment is effective in reducing hs-CRP levels; 26 this underlines the importance of good oral health in maintaining systemic health. 25 Accordingly, health promotion programs that are designed to assist obese patients to lose weight and reduce the risks of cardiovascular disease should include oral health promotion.…”

Section: Discussionmentioning

confidence: 99%

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The Relationship between Body Mass Index and Periodontitis in Arab Patients with Type 2 Diabetes Mellitus

et al. 2015

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

The Relationship between Body Mass Index and Periodontitis in Arab Patients with Type 2 Diabetes Mellitus

et al. 2015

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“…CRP was quantified using ELISA assay (range of detection 0.5–50 mg/l) 52. Intra-plate and inter-plate coefficients of variation ranged from 0–37.3% and 0–10.6%, respectively.…”

Section: Methodsmentioning

confidence: 99%

Cumulative life course and adult socioeconomic status and markers of inflammation in adulthood

Pollitt¹,

Kaufman

Rose

et al. 2008

Journal of Epidemiology & Community Health

119

106

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“…6 Periodontal infections are also associated with increases in systemic markers of inflammation including biomarkers such as C reactive protein. 13 By analogy, edentulism is commonly associated with denture infections (denture mucositis) which induce mucosal inflammation and unclean dentures can also pose as a chronic reservoir of oral pathogens. However, the potential role of denture-based infection as a potential risk factor for COPD remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Obstructive airway disease and edentulism in the atherosclerosis risk in communities (ARIC) study

et al. 2012

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ObjectivesWe examined the potential association between prior chronic obstructive pulmonary disease (COPD) and edentulism, and whether the association varied by COPD severity using data from the Dental Atherosclerosis Risk in Communities Study.DesignCross-sectional.SettingCommunity dwelling subjects from four US communities.Participants and measurementsCases were identified as edentulous (without teeth) and subjects with one or more natural teeth were identified as dentate. COPD cases were defined by spirometry measurements that showed the ratio of forced expiratory volume (1 s) to vital capacity to be less than 0.7. The severity of COPD cases was also determined using a modified Global Initiative for Chronic Obstructive Lung Disease classification criteria (GOLD stage I–IV). Multiple logistic regression was used to examine the association between COPD and edentulism, while adjusting for age, gender, centre/race, ethnicity, education level, income, diabetes, hypertension, coronary heart disease and congestive heart failure, body mass index, smoking, smokeless tobacco use and alcohol consumption.Results13 465 participants were included in this analysis (2087 edentulous; 11 378 dentate). Approximately 28.3% of edentulous participants had prior COPD compared with 19.6% among dentate participants (p<0.0001). After adjustment for potential confounders, we observed a 1.3 (1.08 to 1.62) and 2.5 (1.68 to 3.63) fold increased risk of edentulism among GOLD II and GOLD III/IV COPD, respectively, as compared with the non-COPD/dentate referent. Given the short period of time between the measurements of COPD (visit 2) and dentate status (visit 4) relative to the natural history of both diseases, neither temporality nor insight as to the directionality of the association can be ascertained.ConclusionsWe found a statistically significant association between prior COPD and edentulism, with evidence of a positive incremental effect seen with increasing GOLD classification.

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Relationship Between Periodontal Disease and C-Reactive Protein Among Adults in the Atherosclerosis Risk in Communities Study

Abstract: Extensive periodontal disease and BMI are jointly associated with increased CRP levels in otherwise healthy, middle-aged adults, suggesting the need for medical and dental diagnoses when evaluating sources of acute-phase response in some patients.

Cited by 273 publications

References 31 publications

The Relationship between Body Mass Index and Periodontitis in Arab Patients with Type 2 Diabetes Mellitus

The Relationship between Body Mass Index and Periodontitis in Arab Patients with Type 2 Diabetes Mellitus

Cumulative life course and adult socioeconomic status and markers of inflammation in adulthood

Obstructive airway disease and edentulism in the atherosclerosis risk in communities (ARIC) study

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