The purpose of this study is to examine the mediating effects of depression in the relationship between income inequality and satisfaction in life perceived by female fishermen. To verify the purpose of the study, we used data from a survey of 215 female fishermen residing in Jeollanam-do, Korea, conducted at Jeonnam Women’s Plaza (now “Foundation of Jeonam Women and Family”) in 2016. Hierarchical analysis and Sobel-test using SPSS ver. 21.0 were used in the analysis. As a result of the analysis, it was confirmed that there is a partial mediating effect of depression in the relationship between income inequality and satisfaction in life. Based on the result, we proposed practical and policy recommendations that can improve the satisfaction of female fishermen in their lives.