Relationship between paternal somatic health and assisted reproductive technology outcomes

Li, Shufeng; Wise, Lauren A.; Lynch, Carl; Nakajima, Steven T.; Meyers, Stuart A.; Behr, Barry; Baker, Valerie L.

doi:10.1016/j.fertnstert.2016.04.037

Cited by 10 publications

(20 citation statements)

References 26 publications

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“…The investigators suggested that the presence of erectile dysfunction in infertile men, particularly men with azoospermia, might prompt physicians to evaluate possible subclinical underlying morbidities. An early diagnosis of erectile dysfunction and the identification of its risk factors can provide useful information for eventually stratifying cardiovascular risk 26,27,121,139,140 . Whether or not erectile dysfunction in infertile men might be an earlier marker of cardiovascular diseases needs further investigation.…”

Section: Male Infertility and General Health A Proxy Of General Healthmentioning

confidence: 99%

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Sexual dysfunction and male infertility

2018

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Infertility affects up to 12% of all men, and sexual dysfunction occurs frequently in men of reproductive age, causing infertility in some instances. In infertile men, hypoactive sexual desire and lack of sexual satisfaction are the most prevalent types of sexual dysfunction, ranging from 8.9% to 68.7%. Erectile dysfunction and/or premature ejaculation, evaluated with validated tools, have a prevalence of one in six infertile men, and orgasmic dysfunction has a prevalence of one in ten infertile men. In addition, infertile men can experience a heavy psychological burden. Infertility and its associated psychological concerns can underlie sexual dysfunction. Furthermore, general health perturbations can lead to male infertility and/or sexual dysfunction. Erectile dysfunction and male infertility are considered proxies for general health, the former underlying cardiovascular disorders and the latter cancerous and noncancerous conditions. The concept that erectile dysfunction in infertile men might be an early marker of poor general health is emerging. Finally, medications used for general health problems can cause sperm abnormalities and sexual dysfunction. The treatment of some causes of male infertility might improve semen quality and reverse infertility-related sexual dysfunction. In infertile men, an investigation of sexual, general, and psychological health status is advisable to improve reproductive problems and general health.

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Section: Male Infertility and General Health A Proxy Of General Healthmentioning

confidence: 99%

“…Decreased general health status is associated with impaired male sexual 22 and reproductive 23 health. The concept that male infertility might be an early marker of poor general health is emerging 15,[24][25][26][27] .…”

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confidence: 99%

Sexual dysfunction and male infertility

2018

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“…Fourth, the association between the overall health status and treatment of men and ART outcome remains unclear. A recent study suggested that a man's health status may also be associated with ART success and the birth characteristics of the child (23). Although enhanced spermatogenesis per se was improved by comorbidity treatment, further research should determine whether the treatment of the health conditions of men might influence ART outcomes.…”

Section: Discussionmentioning

confidence: 99%

Effects of medical comorbidity on male infertility and comorbidity treatment on spermatogenesis

Shiraishi

Matsuyama

2018

Fertility and Sterility

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Objective: To investigate the prevalence and effects of medical comorbidities on spermatogenesis and to determine whether the treatment of medical comorbidities effectively improves spermatogenesis. Design: Single-center case-control study. Setting: University hospital. Patient(s): A total of 3,328 infertile men and 452 men with normal results on semen examination, with mean age of 35 years. Intervention(s): Hormonal and spermatogenic parameters were compared between the men with and without medical comorbidities. For the men diagnosed with medical comorbidities during the infertility evaluation, semen parameters were compared between those who did and did not undergo treatment of the comorbidities. Main Outcome Measure(s): Rate of comorbidity, relationship between infertility and comorbidity, comorbidity treatment on total motile sperm count. Result(s): The prevalence of comorbidities was significantly higher in the infertile men (21.7%) than in the fertile men (9.1%), particularly for hypertension (17.8%), hyperlipidemia (5.9%), hyperuricemia (5.2%), and skin disease (3.0%). Among the infertile men, the reproductive functions were aberrant in the men with comorbidity compared with those without comorbidity. After treatment for comorbidities, a significant increase was observed in the total motile sperm count compared with both the baseline values and with the poorly controlled men. A multivariate analysis showed that varicocele and comorbidity treatments were independent predictors of an improved total motile sperm count, with odds ratios of 2.895 and 2.057, respectively. Conclusion(s): Medical comorbidities are associated with impaired sperm production. Male infertility evaluation offers not only specific therapy to improve semen parameters but also therapy for nonspecific medical comorbidities, which may benefit general health status and spermatogenesis restoration.

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“…Additionally, paternal lifestyle and environmental effects could affect offspring via epigenetic changes in spermatozoa influencing offspring phenotype 3,4 . While most studies of paternal influences on offspring to date have explored unassisted conception, much less is known in regard to paternal factors and outcomes within assisted reproductive technologies (ART) though poor paternal health may negatively impact outcomes 5 …”

Section: Introductionmentioning

confidence: 99%

“…3,4 While most studies of paternal influences on offspring to date have explored unassisted conception, much less is known in regard to paternal factors and outcomes within assisted reproductive technologies (ART) though poor paternal health may negatively impact outcomes. 5 Male factor infertility accounts for about 30%-50% of all evaluations of infertility with 7% of men worldwide eventually labeled infertile. 6 As such, a large portion of those couples undergoing ART will utilize semen that may have altered parameters.…”

Section: Introductionmentioning

confidence: 99%

Relationship between male age, semen parameters and assisted reproductive technology outcomes

Kasman

Zhao

et al. 2020

Andrology

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Background Low semen quality often obligates the use of assisted reproductive technology; however, the association between semen quality and assisted reproductive technology outcomes is uncertain. Objectives To further assess the impact of semen quality on assisted reproductive technology outcomes. Materials and Methods A retrospective cohort study was carried out at a single academic reproductive medicine center (January 2012‐December 2018). Patients undergoing at least one assisted reproductive technology cycle utilizing freshly ejaculated spermatozoa from the male partner were included. We assessed the association between semen quality (as stratified based on WHO 5th edition criteria), paternal age (< or ≥40), and reproductive/perinatal outcomes. To evaluate the differences in assisted reproductive technology outcomes by semen parameters and age, generalized estimating equations were applied for rates of fertilization, pregnancy, implantation, miscarriage, live birth, blast formation, gestational age, and normal embryo biopsy. Results A total of 2063 couples were identified who underwent 4517 assisted reproductive technology cycles. Average ages of the male and female partners were 39.8 and 37.7, respectively. Lower pregnancy rates were observed in cycles with lower sperm motility (ie <40%; 39.9% vs 44.1%) and total motile count (ie <9 million; 38.3% vs 43.5%). When examining only cycles utilizing Intracytoplasmic Sperm Injection, only a lower motility count was associated with a decline in pregnancy rate (39.1% vs 44.9%). No association was identified between semen quality and gestational age or birth weight. Paternal age was not associated with ART outcomes. However, among assisted reproductive technology cycles in women <40, aneuploidy rate was higher for older men (P < .001). In cycles with women >40, no association between aneuploidy and male age was identified. Discussion Sperm motility is associated with pregnancy rates, while other semen parameters are not. In cycles in women <40, paternal age is associated with embryo aneuploidy rate. Conclusion Paternal factors are associated with assisted reproductive technology outcomes, and future studies should explore mechanisms by which semen quality is associated with assisted reproductive technology outcomes.

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Relationship between paternal somatic health and assisted reproductive technology outcomes

Abstract: The current report identified a possible relationship between a man's health history and IVF outcomes. As these are potentially modifiable factors, further research should determine whether treatment for men's health conditions may improve or impair IVF outcomes.

Cited by 10 publications

References 26 publications

Sexual dysfunction and male infertility

Sexual dysfunction and male infertility

Effects of medical comorbidity on male infertility and comorbidity treatment on spermatogenesis

Relationship between male age, semen parameters and assisted reproductive technology outcomes

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