Relationship between parental lung function and their children's lung function early in life

Putte‐Katier, Nienke van; Uiterwaal, C S P M; Jong, Brita M. de; Kimpen, Jan L. L.; Verheij, Th.J.M.; Numans, Mattijs E.; Ent, Cornelis K. van der

doi:10.1183/09031936.00034210

Cited by 7 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The research nurse will also assess the presence of eczema using the cumulative objective scoring index for atopic dermatitis (SCORAD) [20] (Table 2). During a separate home visit at 4 months of age, lung function tests will be performed with the Single Occlusion Technique (WHISTLER) by a dedicated research nurse [21,22].…”

Section: Measurements Of the Childmentioning

confidence: 99%

Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study

et al. 2020

View full text Add to dashboard Cite

Epidemiological research has shown there to be a strong relationship between preconceptional, prenatal, birth and earlylife factors and lifelong health. The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design. It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern Netherlands. In Lifelines NEXT we aim to include 1500 pregnant Lifelines participants and intensively follow them, their partners and their children until at least 1 year after birth. Longer-term follow-up of physical and psychological health will then be embedded following Lifelines procedures. During the Lifelines NEXT study period biomaterials-including maternal and neonatal (cord) blood, placental tissue, feces, breast milk, nasal swabs and urine-will be collected from the mother and child at 10 time points. We will also collect data on medical, social, lifestyle and environmental factors via questionnaires at 14 different time points and continuous data via connected devices. The extensive collection of different (bio)materials from mother and child during pregnancy and afterwards will provide the means to relate environmental factors including maternal and neonatal microbiome composition) to (epi)genetics, health and developmental outcomes. The nesting of the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended families within the cohort.

show abstract

Section: Measurements Of the Childmentioning

confidence: 99%

Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In some cases, this may reflect the effects of maternal exposures to environmental toxicants during pregnancy and this is discussed in a subsequent section of this review. However, lung function is also partially under genetic influence and this may contribute to low-lung function in asthmatics (20, 21) and to the familial risk seen in offspring of asthmatic parents. The extent to which genetically determined lung function is altered by postnatal environmental exposures is uncertain.…”

Section: Clinical and Pathological Features Of Asthma As It Developsmentioning

confidence: 99%

Elucidation of Pathways Driving Asthma Pathogenesis: Development of a Systems-Level Analytic Strategy

et al. 2014

View full text Add to dashboard Cite

Asthma is a genetically complex, chronic lung disease defined clinically as episodic airflow limitation and breathlessness that is at least partially reversible, either spontaneously or in response to therapy. Whereas asthma was rare in the late 1800s and early 1900s, the marked increase in its incidence and prevalence since the 1960s points to substantial gene × environment interactions occurring over a period of years, but these interactions are very poorly understood (1–6). It is widely believed that the majority of asthma begins during childhood and manifests first as intermittent wheeze. However, wheeze is also very common in infancy and only a subset of wheezy children progress to persistent asthma for reasons that are largely obscure. Here, we review the current literature regarding causal pathways leading to early asthma development and chronicity. Given the complex interactions of many risk factors over time eventually leading to apparently multiple asthma phenotypes, we suggest that deeply phenotyped cohort studies combined with sophisticated network models will be required to derive the next generation of biological and clinical insights in asthma pathogenesis.

show abstract

“…Pulmonary function measures show familial aggregation, with evidence for genetic effects in twin and family studies 9,10 . We previously reported associations between FEV 1 or FEV 1 /FVC and at least 27 genetic loci using large-scale meta-analyses of genome-wide association studies (GWAS) 11–14 .…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association analysis identifies six new loci associated with forced vital capacity

et al. 2014

View full text Add to dashboard Cite

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10−8) with FVC in or near EFEMP1, BMP6, MIR-129-2/HSD17B12, PRDM11, WWOX, and KCNJ2. Two (GSTCD and PTCH1) loci previously associated with spirometric measures were related to FVC. Newly implicated regions were followed-up in samples of African American, Korean, Chinese, and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and pathogenesis of restrictive lung disease.

show abstract

Relationship between parental lung function and their children's lung function early in life

Cited by 7 publications

References 27 publications

Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study

Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study

Elucidation of Pathways Driving Asthma Pathogenesis: Development of a Systems-Level Analytic Strategy

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Contact Info

Product

Resources

About