“…The aetiology of the origin is unknown, but the main theories include abnormal embryologic development of the sphenoid bone, ossification of the ligaments between the clinoid processes [9], or infection of the pituitary gland. The literature also suggests that its abnormal morphology is related to genetic syndromes affecting the craniofacial complex, such as Axenfeld-Rieger syndrome, basal cell naevus syndrome, Down's syndrome, William's syndrome, Freeman-Burian syndrome, Focal Dermal Hypoplasia, Osteogenesis imperfecta and Single Maxillary Midline Central Incisor syndrome [10], and genetically determined dental anomalies such as palatal canine impaction (PCI), hypodontia, dental transposition, mandibular second premolar agenesis, and maxillary lateral incisor agenesis [11][12][13][14][15][16][17][18][19].…”