“…This suggests production of important metabolic products is highest in the early stages and then decreases during the later stages of the growth. For example, extracellular fatty acid formation during growth of C. lipolytica peaks at an early stage as shown by Sobotka et al (1974). They also showed that high oxygen uptake rates coincide with the accumulation of extracellular fatty acids, and in the latter phases of fermentation fatty acids are partially incorporated into cellular components.…”