Relationship between oxygen cost and C-reactive protein response to marathon running in college recreational runners

Abstract

PurposeIndividual variations in response of C-reactive protein (CRP) to acute strenuous exercise are less well known. The purpose of this study was to investigate the relationship between running economy and systemic inflammation following a marathon.Materials and methodsSixteen college recreational runners participated in this study. To measure maximal oxygen uptake and running economy, the treadmill running test was performed 1–2 weeks before the marathon race. Running economy was defined as oxygen cost (mL/kg/km) at submaximal running. CRP and muscle damage markers (creatine kinase and lactate dehydrogenase) were measured before and 1, 2, and 3 days after the race.ResultsAll subjects completed the race in 4 hours 7 minutes 43 seconds±44 minute 29 seconds [mean±SD]. The marathon running significantly increased CRP and muscle damage markers. The levels of inflammation and muscle damage peaked after 1 day and remained high throughout the 3-day recovery period compared to that before the race. Spearman correlation analysis showed that the change in CRP level was significantly positively correlated with oxygen cost (r=0.619, P=0.011) but not maximal oxygen uptake. There was no significant relationship in responses between muscle damage markers and CRP.ConclusionThese findings suggest that running economy is related to postmarathon race CRP response. Further study to clarify the cause of the relationship and clinical significance of transient increase in CRP is necessary.

Isha Yoga Practices and Participation in Samyama Program are Associated with Reduced HbA1C and Systemic Inflammation, Improved Lipid Profile, and Short-Term and Sustained Improvement in Mental Health: A Prospective Observational Study of Meditators

“…Samyama is an intensive process with an estimated time of meditation/yoga practice of 15 h/day over the course of 8 days. This likely resulted in acute inflammation in Samyama participants, similar to observations made in marathon runners (Takayama et al, 2018 ). Higher CRP levels have been linked to increased HbA1c levels (Liu et al, 2015 ).…”

Changes in running economy and attainable maximal oxygen consumption in response to prolonged running: The impact of training status

“…This raises the question whether prolonged running may lead to larger drift in physiological characteristics than prolonged cycling 4 . Arguably, the repetitive foot strikes during running may have larger impact on the working musculature, possibly leading to muscle damage, 23 especially in subjects that are not used to prolonged running, such as AA. Exercising in the heat (35°C), Wingo, Stone and Ng 9 observed similar decrements in VO 2max after 45 min of running and cycling at 60% of VO 2max , advocating that this may not be the case.…”

Exercise Intensity during Olympic-Distance Triathlon in Well-Trained Age-Group Athletes: An Observational Study

“…The gross efficiency during cycling was calculated as described in a previous study [ 34 ]. The running economy was expressed as the O 2 cost (ml·kg −1 ·km −1 ) and was calculated based on the last 1-min O 2 while running for 5 min (9.0 km·h −1 ) [ 35 ].…”