Relationship between ovarian response and number of euploid embryos in oocyte donor cycles

Labarta, E.; Bosch, Ernesto; Mercader, Amparo; Alamá, Pilar; Mateu, Emilia; Pellicer, A.

doi:10.1016/j.fertnstert.2012.07.1025

Cited by 2 publications

(2 citation statements)

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“…This is in line with recent studies, which do not support the idea that ovarian stimulation is so detrimental to oocyte and embryo quality. In fact, it has been shown that high ovarian response to conventional ovarian stimulation does not increase embryo aneuploidy rates in preimplantational genetic screening (PGS) cycles using array comparative genomic hybridization, either in infertile patients or in oocyte donors (52,53). Moreover, the more euploid blastocysts that are available, the higher the clinical pregnancy rate, even in fresh cycles (54,55), and the higher the ovarian response, the higher the cumulative pregnancy rate after including thawed embryo transfers (5,6).…”

Section: Gonadotropin Doses and Oocyte Qualitymentioning

confidence: 99%

Regimen of ovarian stimulation affects oocyte and therefore embryo quality

Bosch

Labarta

Kolibianakis

et al. 2016

Fertility and Sterility

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Without any doubt the regimen used to mature multiple capable oocytes for IVF impacts IVF outcomes. Studies have indicated that the inclusion of LH activity, adjuvant agents such as growth hormone (GH), and regimens providing for simultaneous action of both LH and FSH during final oocyte maturation may have beneficial effects on IVF outcomes. Because of the difficulty in improving IVF outcomes in poor responders, the studies on GH are of particular interest. As pointed out in this review, the apparent beneficial effects of GH on oocyte competence may also apply to older women or to normal responders with reduced embryo quality. A much more difficult question is whether and how much ovarian stimulation impacts on oocyte competence. Paradoxically it seems that there are not demonstrated differences between the stimulated and the natural unstimulated cycle, whereas studies in laboratory animals and IVF patients have shown deleterious effects of higher compared with lower doses of gonadotropins. Recent studies suggest that the use of high doses of gonadotropins as an independent factor correlates negatively with the probability of live birth, whereas a high ovarian response per se is associated with better cumulative pregnancy rates, owing to the availability of more euploid and good-quality embryos. Although adjunctive use of androgens has not been discussed here, it is briefly covered in the first review of this series.

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Section: Gonadotropin Doses and Oocyte Qualitymentioning

confidence: 99%

Regimen of ovarian stimulation affects oocyte and therefore embryo quality

Bosch

Labarta

Kolibianakis

et al. 2016

Fertility and Sterility

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show abstract

“…As for humans, it was suggested that the euploid oocyte rate was directly proportional to the number of mature oocytes and inversely proportional to the number of gonadotropin units used per mature oocyte obtained [29,30]. Studies conducted with preimplantation genetic screening (PGS) showed that high ovarian response to conventional ovarian stimulation did not raise embryo aneuploidy rates [31,32].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Clinical Outcomes after Poor-Quality Embryo Transfer and Prognostic Parameters

Kadioglu,

Kahyaoğlu,

Kaplanoğlu

et al. 2023

JCM

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We aimed to investigate the clinical results following poor-quality embryo transfer and the parameters to foresee the prognosis. In this study, 2123 cycles that had day 3 and day 5 single-fresh embryo with poor-quality embryo transfers and good-quality embryo transfers were compared. The cycles according to transfer day were evaluated by conducting a subgroup analysis. The correlation between all the obtained demographic characteristics, controlled ovarian stimulation parameters, and cycle results were analysed. Clinical pregnancy was established in 53 patients that underwent transfer in the poor-quality embryo group (14.9%). Of these patients, 36 had live birth (live birth rate per clinical pregnancy 67.9%). In cleavage-stage embryos, live birth rates per clinical pregnancy were higher in poor-quality blastocyst transfer. When analysing the factors affecting live births in the poor-quality embryo group, as the total gonadotropin dose increases, the probability of live birth decreases, as in the probability of hCG positivity. In conclusion, although the probability of pregnancy is low, when clinical pregnancy is established, there is a high chance of having a live birth after poor-quality embryo transfers. This could be regarded as an acceptable option in cycles when only poor-quality embryos are available.

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Relationship between ovarian response and number of euploid embryos in oocyte donor cycles

Cited by 2 publications

References 0 publications

Regimen of ovarian stimulation affects oocyte and therefore embryo quality

Regimen of ovarian stimulation affects oocyte and therefore embryo quality

Evaluation of Clinical Outcomes after Poor-Quality Embryo Transfer and Prognostic Parameters

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