Relationship Between Ovarian Production of Estrone, Estradiol, Testosterone, and Androstenedione and the Ovarian Degree of Stromal Hyperplasia in Postmenopausal Women

Sluijmer, Alexander V.; Heineman, Maas Jan; Koudstaal, J; Theunissen, P. H. M. H.; Jong, Frank H. de; Evers, J.L.H.

doi:10.1097/00042192-199805040-00004

Cited by 28 publications

(30 citation statements)

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“…Because of the unique anatomic proximity of the ovary and the uterus, and anastomozing ovarian and uterine vessels, testosterone secreted from the postmenopausal ovary may constitute a significant portion of the precursors of estradiol, which contribute to tumorigenesis of endometrial cancer (27). It has been noted that androgen secretion is increased from ovaries showing stromal hyperplasia (24,28,29), and women with endometrioid endometrial cancer show ovarian stromal hyperplasia more frequently than women without endometrial cancer (28,30).…”

Section: Discussionmentioning

confidence: 99%

Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival

Segawa

Shozu

Murakami

et al. 2005

Clinical Cancer Research

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Section: Discussionmentioning

confidence: 99%

Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival

Segawa

Shozu

Murakami

et al. 2005

Clinical Cancer Research

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“…These stromal cells contain both 3 -HSD and type 5 17 -HSD, thus permitting the transformation of DHEA into 4-dione and then into testosterone. The amount of stromal hyperplasia in postmenopausal ovaries is correlated with the ovarian vein levels of 4-dione and testosterone (Sluijmer et al 1998). These hyperplastic stromal cells are thus responsible for the synthesis of 4-dione and testosterone in the postmenopausal ovary.…”

Section: Steroidogenic Enzymesmentioning

confidence: 99%

Is dehydroepiandrosterone a hormone?

Labrie¹,

Luu‐The²,

Bélanger³

et al. 2005

Journal of Endocrinology

384

242

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Dehydroepiandrosterone (DHEA) is not a hormone but it is a very important prohormone secreted in large amounts by the adrenals in humans and other primates, but not in lower species. It is secreted in larger quantities than cortisol and is present in the blood at concentrations only second to cholesterol. All the enzymes required to transform DHEA into androgens and/or estrogens are expressed in a cellspecific manner in a large series of peripheral target tissues, thus permitting all androgen-sensitive and estrogensensitive tissues to make locally and control the intracellular levels of sex steroids according to local needs. This new field of endocrinology has been called intracrinology. In women, after menopause, all estrogens and almost all androgens are made locally in peripheral tissues from DHEA which indirectly exerts effects, among others, on bone formation, adiposity, muscle, insulin and glucose metabolism, skin, libido and well-being. In men, where the secretion of androgens by the testicles continues for life, the contribution of DHEA to androgens has been best evaluated in the prostate where about 50% of androgens are made locally from DHEA. Such knowledge has led to the development of combined androgen blockade (CAB), a treatment which adds a pure anti-androgen to medical (GnRH agonist) or surgical castration in order to block the access of the androgens made locally to the androgen receptor. In fact, CAB has been the first treatment demonstrated to prolong life in advanced prostate cancer while recent data indicate that it can permit long-term control and probably cure in at least 90% of cases of localized prostate cancer. The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women's health at menopause.

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“…In a study of 112 women with endometrioid endometrial carcinoma and 47 women with benign diseases, Jongen et al [14] found that increasing degrees of ovarian stromal hyperplasia were related to significantly higher levels of ovarian vein androstenedione and testosterone concentrations and endometrial carcinoma. Similarly, Sluijmer et al [15] in a smaller investigation reported significant associations between ovarian stromal hyperplasia and venous androgen levels. Lucisano et al [16] also found significant associations between ovarian stromal hyperplasia and ovarian vein androgen levels, but not with endometrial carcinoma based on an analysis of 35 cancer patients and 23 patients with benign diseases.…”

Section: Introductionmentioning

confidence: 75%

“…Ovarian volumes were estimated as the product of the three ovarian dimensions X 0.523 [15,21,22]. Ovaries that contained cysts ≥ 1.0 cm in maximum dimension (or multiple cysts measuring ≥ 1.0 cm in aggregate) or benign tumors were excluded.…”

Section: Ovarian Volume Epidemiologic Exposures and Serum Hormone Lementioning

confidence: 99%

Ovarian volumes among women with endometrial carcinoma: Associations with risk factors and serum hormones

Sherman¹,

Madigan²,

Lacey³

et al. 2007

Gynecologic Oncology

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Objectives-Data suggest that post-menopausal women with larger ovaries are at increased risk for endometrial carcinoma; however, analyses comparing ovarian volume to serum hormone levels are limited. Accordingly, we assessed ovarian volumes in relation to serum sex hormone levels among post-menopausal women with endometrial carcinoma who participated in a multi-center case control study.Methods-Data for established risk and protective factors for endometrial carcinoma were collected via in-person interviews. Ovarian volumes were estimated from pathology reports. Associations between exposures and age-adjusted ovarian volumes were analyzed for 175 cases with available data. For a subset of 135 cases, we analyzed relationships between ovarian volume, adjusted for age and body mass index (BMI), and serum hormone levels by analysis of variance.Results-Ovarian volume declined progressively from 1.83 cm 3 among women ages 55-59 years to 1.23 cm 3 among women age 70 years or older (p-trend = 0.02). Larger ovarian volume was associated with early menarche (p-trend = 0.03), having given birth (p = 0.01), and weakly with elevated BMI (p-trend = 0.06). After adjustment, increased ovarian volume, was associated with higher estradiol (p -trend = 0.007); albumin-bound estradiol (p -trend = 0.01); and free estradiol (p -trend = 0.006) levels; androstenedione, estrone and estrone sulfate showed similar, though nonsignificant associations.Conclusions-Among women with endometrial carcinoma, larger ovaries were associated with higher serum levels of estrogens. Further studies examining the role of the ovaries in post-menopausal hormonal carcinogenesis are warranted.

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Relationship Between Ovarian Production of Estrone, Estradiol, Testosterone, and Androstenedione and the Ovarian Degree of Stromal Hyperplasia in Postmenopausal Women

Cited by 28 publications

References 0 publications

Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival

Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival

Is dehydroepiandrosterone a hormone?

Ovarian volumes among women with endometrial carcinoma: Associations with risk factors and serum hormones

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