Relationship between ovarian cortisol:cortisone ratios and the clinical outcome of <i>in vitro</i> fertilization and embryo transfer (IVF‐ET)

Michael, Anthony E.; Collins, Tracey D.; Norgate, Dean P.; Gregory, Linda; Wood, Peter; Cooke, Brian A.

doi:10.1046/j.1365-2265.1999.00892.x

Cited by 37 publications

(20 citation statements)

References 24 publications

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“…This results in a rapid increase in follicular cortisol just before follicular rupture (Harlow et al 1997). The physiological importance of this event is not clear but it may enhance oocyte maturation (Fateh et al 1989, Michael et al 1999 or prevent excess inflammation caused by ovulation (Hillier & Tetsuka 1998). In the present study, however, all follicles were collected before the gonadotrophin surge and thus the presence of a similar mechanism in the bovine preovulatory follicles is still to be clarified.…”

Section: Discussionmentioning

confidence: 59%

“…The physiological importance of this phenomenon is not clear. It is suggested, however, that the increased level of cortisol may enhance oocyte maturation (Fateh et al 1989, Michael et al 1999 or suppress inflammation associated with ovulation, thereby promoting rapid healing of the wound left by follicular rupture (Hillier & Tetsuka 1998). In pregnant rat corpora lutea (CL), the expression of 11HSD2 was shown to be dramatically up-regulated, which was coincident with the rise in circulating glucocorticoid just prior to parturition (Waddell et al 1996).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of 11beta-hydroxysteroid dehydrogenases in bovine follicle and corpus luteum

Tetsuka¹,

Yamamoto²,

Hayashida³

et al. 2003

Journal of Endocrinology

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In glucocorticoid target organs, local concentrations of active glucocorticoid are determined by the relative expression of two 11 -hydroxysteroid dehydrogenases (HSDs): bi-directional 11 -HSD type1 (11HSD1) that mainly activates cortisone to cortisol, and dehydrogenase 11 -HSD type2 (11HSD2) that inactivates cortisol to cortisone. In this study, we examined the expression of mRNA encoding these two 11 -HSDs in bovine granulosa cells harvested from preovulatory follicles and corpora lutea (CL). Ovaries were obtained from Holstein cows at a local slaughterhouse. Follicles larger than 10 mm in diameter and CL were dissected and follicular fluid and granulosa cells were taken. Corpora lutea were weighed and their stages were morphologically assessed (stage I, days 1-4; stage II, days 5-10; stage III, days 11-17; stage IV, days 8-20). Follicles were classified into four groups according to their hormonal status (oestradiol (E 2 ): progesterone (P 4 )>1: oestrogen active; E 2 :P 4 <1: oestrogen inactive) and stage of the oestrous cycle (luteal or follicular phase). Total RNA was extracted with phenol-chloroform and subjected to a semi-quantitative RT-PCR for 11HSD1, 11HSD2 and -actin. Concentrations of steroids in follicular fluid were determined by an enzyme immunoassay. In granulosa cells, only 11HSD1 mRNA was detected. There was a negative correlation between the expression of 11HSD1 and the concentration of cortisol in follicular fluid (P<0·05), indicating 11HSD1 may act as a dehydrogenase in the bovine follicle. Both types of 11 -HSDs were expressed in CL. The levels of mRNA for both isozymes were high in stage I and II, and were decreased in stage III CL. In stage IV CL, the expression of 11HSD2 but not 11HSD1 mRNA increased. These results indicate that the bovine granulosa cells and CL express 11HSD1 and 11HSD2, and they may play an important physiological role in the bovine ovary through modulating the local glucocorticoid environment.

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Expression of 11beta-hydroxysteroid dehydrogenases in bovine follicle and corpus luteum

Tetsuka¹,

Yamamoto²,

Hayashida³

et al. 2003

Journal of Endocrinology

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“…Three studies reported significant associations between elevated cortisol in follicular fluid and increased likelihood of clinical pregnancy (Andersen and Hornnes., 1994;Keay et al, 2002;Thurston et al, 2003). Four studies showed the opposite relationship albeit at different stages of treatment (Demytteneare et al, 1992;Micheal et al, 1999;An et al, 2011;An et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Second, studies measured cortisol at different stages of treatment. Whilst IVF is a useful clinical model for exploring the effects of stress on reproductive outcomes, over half of the studies (7/12) measured cortisol following gonadotrophin administration (Andersen et al, 1994;Keay et al, 2002;Thurston et al, 2003;Micheal et al, 1999;Lovely et al, 2003;Lewicka et al, 2003;Nouri et al, 2011). Gonadotrophins have profound effects on the HPA axis and, therefore, are likely to have confounded any observed associations between HPA function and pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF

Massey

Campbell

Raine‐Fenning

et al. 2016

Psychoneuroendocrinology

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A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.uk These findings provide preliminary evidence that longer term systemic cortisol may influence reproductive outcomes; and in turn suggests that interventions to reduce cortisol prior to commencing IVF could improve treatment outcomes.

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“…Cortisol is a glucocorticoid hormone which plays an important role in numerous processes including metabolism, blood pressure, and immune response regulation, and thus has proved a reliable biological correlate of many adverse health outcomes [5]. In the context of IVF, a growing body of evidence suggests that stress may exert its deleterious effects on IVF treatment outcomes through activation of the HPA axis [6][7][8][9][10][11].This hypothesis is plausible because both physical and emotional stress can cause alterations to the endocrine axis which may, in turn, affect the reproductive system through immunosuppression [12]. However, although a relationship between the HPA axis and reproductive success is possible, the evidence for a cortisol and IVF association appears inconclusive, with a number of studies reporting an association [7,8,11,[13][14][15] and others reporting no association between cortisol levels and IVF treatment outcomes [9,10,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

The association of physiological cortisol and IVF treatment outcomes: a systematic review

Massey

Campbell

Raine‐Fenning

et al. 2014

Reprod Medicine & Biology

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Purpose A systematic review was conducted to (1) collate and synthesise the available evidence for the role of cortisol in relation to IVF treatment outcomes; (2) to establish the strength of an association between cortisol and IVF; and (3) to assess the overall quality of the studies and guide future research in this area. Methods Seven electronic databases, including the reference lists of published papers, were searched. Inclusion criteria qualified any prospective/observational cohort study that reported original data. Quality assessment of eligible studies was conducted using the STROBE statement, which was used to assess the risk of bias and the quality of observational studies included in this review. Result(s) A total of eight studies reported a significant association between cortisol and IVF outcomes. Three studies found that higher cortisol may be associated with more favourable IVF outcomes, whereas five studies found that lower cortisol levels may be conducive to IVF success. Eleven of all studies included in this review were regarded as low quality publications. Conclusion(s) Study findings were that the evidence for the role of cortisol in relation to IVF outcomes is currently mixed. Future researchers are encouraged to consider the methodological limitations highlighted in this review and to utilise more robust assessment methods when examining the influence that chronic, rather than acute, stress may have on IVF outcomes.

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Relationship between ovarian cortisol:cortisone ratios and the clinical outcome of in vitro fertilization and embryo transfer (IVF‐ET)

Cited by 37 publications

References 24 publications

Expression of 11beta-hydroxysteroid dehydrogenases in bovine follicle and corpus luteum

Expression of 11beta-hydroxysteroid dehydrogenases in bovine follicle and corpus luteum

Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF

The association of physiological cortisol and IVF treatment outcomes: a systematic review

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