Relationship Between Oropharyngeal Geometry and Vocal Parameters in Subjects With Parkinson's Disease

Paulino, Clarissa Evelyn Bandeira; Silva, Hilton Justino da; Gomes, Adriana de Oliveira Camargo; Silva, Joice Maely Souza da; Cunha, Daniele Andrade da; Coriolano, Maria das Graças Wanderley de Sales; Lopes, Leonardo Wanderley; Lira, Zulina Souza de

doi:10.1016/j.jvoice.2022.01.020

Cited by 1 publication

(1 citation statement)

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“…Various acoustic parameters measured by the state-of-the-art technologies such as the Praat 12 , wavesurfer 13 , Dysarthria Analyzer 14 , and commercial Visi-Pitch 15 proved to be sensitive to prodromal, early, and developed stages of PD for non-tonal languages 16 . However, one of the main prerequisite for acoustic analyses is that the speech paradigms are suitable for the language given its pronunciation characteristics.…”

Section: Introductionmentioning

confidence: 99%

Acoustic assessment in mandarin-speaking Parkinson’s disease patients and disease progression monitoring and brain impairment within the speech subsystem

Diao,

Xie,

Wang

et al. 2024

npj Parkinsons Dis.

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Approximately 90% of Parkinson’s patients (PD) suffer from dysarthria. However, there is currently a lack of research on acoustic measurements and speech impairment patterns among Mandarin-speaking individuals with PD. This study aims to assess the diagnosis and disease monitoring possibility in Mandarin-speaking PD patients through the recommended speech paradigm for non-tonal languages, and to explore the anatomical and functional substrates. We examined total of 160 native Mandarin-speaking Chinese participants consisting of 80 PD patients, 40 healthy controls (HC), and 40 MRI controls. We screened the optimal acoustic metric combination for PD diagnosis. Finally, we used the objective metrics to predict the patient’s motor status using the Naïve Bayes model and analyzed the correlations between cortical thickness, subcortical volumes, functional connectivity, and network properties. Comprehensive acoustic screening based on prosodic, articulation, and phonation abnormalities allows differentiation between HC and PD with an area under the curve of 0.931. Patients with slowed reading exhibited atrophy of the fusiform gyrus (FDR p = 0.010, R = 0.391), reduced functional connectivity between the fusiform gyrus and motor cortex, and increased nodal local efficiency (NLE) and nodal efficiency (NE) in bilateral pallidum. Patients with prolonged pauses demonstrated atrophy in the left hippocampus, along with decreased NLE and NE. The acoustic assessment in Mandarin proves effective in diagnosis and disease monitoring for Mandarin-speaking PD patients, generalizing standardized acoustic guidelines beyond non-tonal languages. The speech impairment in Mandarin-speaking PD patients not only involves motor aspects of speech but also encompasses the cognitive processes underlying language generation.

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