Relationship Between Obstructive Sleep Apnea Severity and Brain Activation During a Sustained Attention Task

Ayalon, Liat; Ancoli‐Israel, Sonia; Aka, Allison A.; McKenna, Benjamin S.; Drummond, Sean P.A.

doi:10.1093/sleep/32.3.373

Cited by 115 publications

(75 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previously, we examined group differences between OSA and control subjects in performance and brain activation (4,6). Here, we extend those analyses by specifically examining the combined impact of increasing age and OSA on cognition and brain activation.…”

Section: What This Study Adds To the Fieldmentioning

confidence: 85%

Obstructive Sleep Apnea and Age

Ayalon¹,

Ancoli‐Israel

Drummond³

2010

Am J Respir Crit Care Med

Self Cite

View full text Add to dashboard Cite

Rationale: Healthy aging is associated with cognitive deficits similar to those found in obstructive sleep apnea (OSA). As in OSA, older adults show compensatory cerebral activation during cognitive demands in the face of neurocognitive decline. Objectives: The current study examines whether the combination of increasing age and sleep apnea will lead to a stronger compensatory response than either factor alone, or overwhelm the brain's capacity to compensate. Methods: A total of 14 treatment-naive patients with sleep apnea (aged 25-59 yr) and 14 age-matched healthy control subjects were each divided into two age groups of young (,45 yr) and middleaged (> 45 yr). All underwent a sleep study, followed the next morning by a functional magnetic resonance imaging session that included a sustained attention and a verbal encoding task. A priori contrast analyses compared middle-aged patients with OSA to young patients, young control subjects, and middle-aged control subjects. Measurements and Main Results: Middle-aged patients with OSA showed reduced performance for immediate word recall and slower reaction time during sustained attention compared with the other three groups (middle-aged control, young sleep apnea, and young control). For both tasks, decreased activation was detected for middle-aged sleep apnea relative to the other groups in task-related brain regions. Conclusions: These results suggest that the presence of both sleep apnea and increasing age overwhelmed the brain's capacity to respond to cognitive challenges with compensatory recruitment and to maintain performance. The findings that sleep apnea impairs performance and brain function at a younger age than what might ordinarily be expected underscore the importance of early diagnosis and treatment of sleep apnea.

show abstract

Section: What This Study Adds To the Fieldmentioning

confidence: 85%

Obstructive Sleep Apnea and Age

Ayalon¹,

Ancoli‐Israel

Drummond³

2010

Am J Respir Crit Care Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…Defi cits in memory and in short and sustained attention have been attributed to daytime sleepiness due to fragmented sleep, while defi cits in verbal functioning, problem-solving, and executive functions have been attributed to nocturnal hypoxemia. 1,2 Vigilance and alertness are considered vital not only in traffi c, but in many high-risk occupations as well. Furthermore, vigilance is fundamental to all other aspects of cognition.…”

Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%

The Oxford Sleep Resistance test (OSLER) and the Multiple Unprepared Reaction Time Test (MURT) Detect Vigilance Modifications in Sleep Apnea Patients

Alakuijala

Maasilta

Bachour

2014

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

“…21,22 Sustained attention, in particular, is one of the most commonly affected cognitive problems for OSA patients. [23][24][25][26][27] Such cogni-…”

Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%

The Relationship between Psychomotor Vigilance Performance and Quality of Life in Obstructive Sleep Apnea

Lee

Bardwell²,

Ancoli‐Israel³

et al. 2011

Journal of Clinical Sleep Medicine

Self Cite

View full text Add to dashboard Cite

Objective: Patients with obstructive sleep apnea (OSA) commonly have cognitive complaints, particularly in attention, and report decreased quality of life. We examined how vigilance and sustained attention, as assessed by the Psychomotor Vigilance Task (PVT), were related to quality of life after controlling for apnea severity and depression in subjects with OSA. Subjects and Methods: Fifty-seven patients with newly diagnosed and untreated OSA had their sleep monitored with polysomnography. Quality of life was assessed by the Short Form-36 health survey questionnaire (SF-36). Mood was assessed by the Center for Epidemiologic Studies-Depression (CES-D) Scale. After sleep monitoring and psychological assessments were performed, the 10-minute PVT was administered. The main outcome variables were PVT lapse count and average response time (RT). Simple correlations and multiple linear regression were used to examine the association between PVT performance and age, body mass index, sleep variables, apnea hypopnea index, oxygen desaturation index, and CES-D. Results and Conclusion: Both the PVT lapse count and RT were significantly associated with the SF-36 physical component summary score (PCS). In multiple linear regression, PVT RT was an independent predictor of the SF-36 PCS (full model R 2 = 0.331, p = 0.003). PVT lapse was also an independent predictor of the SF-36 PCS (full model R 2 = 0.320, p = 0.004). However, neither PVT RT nor lapse was a significant independent predictor of the SF-36 mental component summary score (MCS). Only CES-D was an individual predictor of the SF-36 MCS (β = -0.676, p < 0.001). Impairments in sustained attention and vigilance may underlie the limitations in physical health-related quality of life reported by people with OSA, even after controlling for demographic variables, apnea severity, and depression. S C I E N T I F I C I N V E S T I G A T I O N SO bstructive sleep apnea (OSA) is a chronic condition characterized by repetitive upper airway obstruction during sleep, leading to apneic episodes, hypoxemia, and recurrent arousals from sleep.1 It has been estimated that 2% to 4% of middle-aged men and 1% to 2% of middle-aged women suffer from OSA, 2 and the rate is even higher in older adults. 3 OSA is associated with considerable morbidity and mortality, particularly from hypertension, cardiovascular disease, and insulin resistance.4,5 Furthermore, the excessive daytime sleepiness associated with OSA can result in an increased risk for motor vehicle crashes 6 or serious industrial accidents. 7People with OSA commonly report having a decreased quality of life (QoL). 8,9 Previous studies have reported that these patients have a significant impairments in virtually every domain of health-related QoL, with the most consistent impairments found in the domains of sleep and vitality/energy. 10 Interestingly, studies have not consistently demonstrated a linear relationship between physiologic measures of OSA severity (i.e., apnea hypopnea index [AHI] or degree of nocturnal oxygen desaturat...

show abstract

Relationship Between Obstructive Sleep Apnea Severity and Brain Activation During a Sustained Attention Task

Cited by 115 publications

References 36 publications

Obstructive Sleep Apnea and Age

Obstructive Sleep Apnea and Age

The Oxford Sleep Resistance test (OSLER) and the Multiple Unprepared Reaction Time Test (MURT) Detect Vigilance Modifications in Sleep Apnea Patients

The Relationship between Psychomotor Vigilance Performance and Quality of Life in Obstructive Sleep Apnea

Contact Info

Product

Resources

About