Relationship Between Neutrophil-To-Lymphocyte Ratio, Muscle Mass and Fat Mass Percentage with Quality of Life in Non-Small Cell Lung Cancer

Abstract

Background: Cachexia is a challenging condition characterized by the loss of muscle and/or fat mass, often seen in cancer patients. Assessing the impact of inflammatory markers like Neutrophil-to-Lymphocyte Ratio (NLR) along with muscle and fat mass on quality of life can provide valuable insights for improving the management and treatment of patients with non-small cell lung cancer. Method: This was an analytical observational analytic study conducted using a cross-sectional design in Bali from August to September 2023. Univariate analysis presents data in the form of frequency, median, mean and standard deviation. Bivariate analysis was carried out using Chi-Square and multivariate analysis using multiple logistic regression. Result: The total number of research subjects who met the requirements were 93 patients. The analysis showed a significant relationship between NLR and muscle mass (CI: 95%, OR: 2.373, p-value = 0.042) while there was no relationship between NLR and fat mass percentage (CI: 95%, OR: 1.568, p value = 0.382). Variables NLR (CI: 95%, adjOR: 0.217, p value=0.032), muscle mass (CI: 95%, adjOR: 12.207, p value=0.002), fat mass (CI: 95%, adjOR: 9.128, p-value =0.020) is significantly related to quality of life. Conclusion: NLR levels, muscle mass, and fat mass percentage have a significant relationship with the quality of life of NSCLC patients. The NLR was related to muscle mass, while there is no relationship between NLR and the percentage of muscle mass.