Relationship between Neuron-specific Enolase Serum Levels with Lesion Volume and Clinical Outcome in Acute Stroke Patients

Abstract

BACKGROUND: Neuron-specific enolase (NSE) is released in the cerebrospinal fluid and bloodstream in response to brain damage. Serum NSE levels can be used as a marker of brain nerve cells either in ischemic or hemorrhagic stroke, associated with lesion volume and functional outcome. AIM: The aim of the study was to evaluate the correlation between NSE serum level with lesion volume and functional outcome in acute stroke patients. METHODS: A cross-sectional study was conducted on 29 patients with ischemic stroke and 29 hemorrhagic strokes admitted to Haji Adam General Hospital. All the subjects were assessed with the National Institute of Health Stroke Scale (NIHSS) score, modified Rankin scale (mRS), and assessment of lesion volume. RESULTS: Subjects consist of 27 male (46.4%) and 31 female (53.4%), with mean age of 61.67 ± 12.26 years. The mean serum NSE levels in stroke patients were 19.79 ± 8.88 ng/ml and lesion volume was 25.09 ± 24.52 ml. There was a significant positive correlation of increase in serum NSE levels with infarct volume (r = 0.863 and p < 0.001) and hemorrhagic volume (r = 0.644 and p < 0.001) and clinical outcome assessed by NIHSS score (r = 0.761 and p < 0.001) and mRS score (r = 0.762 and p < 0.001) in ischemic stroke and NIHSS score (r = 0.525 and p = 0.003), and mRS score (r = 0.468 and p = 0.010) in hemorrhagic stroke. CONCLUSION: High NSE serum levels in the acute phase were associated with lesion volume and poor outcomes in stroke patients.

Neuron-specific enolase in hypertension patients with acute ischemic stroke and its value forecasting long-term functional outcomes

“…In addition, a significant correlation between serum NSE level and NIHSS score in ischemic stroke (r = 0.216, p < 0.023) was found in this study, which is similar to Nasution et al [ 19 ]. The results indicated that the serum NSE level in AIS patients was positively correlated with the severity of the disease.…”

“…Using the developmental cohort of the forward-looking and continuous hospital stroke registry at the First Affiliated Hospital of Wenzhou Medical University, we have established a nomogram based on age, the NIHSS, PT and serum NSE levels, which was constructed to explore the underlying influence of NSE in the prediction of functional outcomes. While high NSE serum levels in the acute phase were associated with poor outcomes in stroke patients were confirmed in previous research [ 19 ], this is the first study to explore the relationship between serum NSE levels and long-term prognosis of acute ischemic stroke in hypertension patients.…”

Biomarkers for prognostic functional recovery poststroke: A narrative review

“…NSE levels were measured in blood samples taken between 12 and 48 h after symptom onset, and NSE has positively correlated to the neurological outcome in stroke patients ( González-García et al, 2012 ). In CSF and blood samples taken from both ischemic and hemorrhagic stroke patients, NSE was identified between four and 8 hours after symptom onset ( Nasution and Bangun, 2022 ). NSE levels positively correlated with functional outcomes assessed using the NIHSS and mRS at 14 days post-stroke ( Nasution and Bangun, 2022 ).…”

“…In CSF and blood samples taken from both ischemic and hemorrhagic stroke patients, NSE was identified between four and 8 hours after symptom onset ( Nasution and Bangun, 2022 ). NSE levels positively correlated with functional outcomes assessed using the NIHSS and mRS at 14 days post-stroke ( Nasution and Bangun, 2022 ). In blood samples taken within the first 48 h after ischemic stroke, high NSE levels were correlated with the severity of neurological symptoms, assessed by the NIHSS ( Kurakina et al, 2021 ).…”

Assessment of Serum Neuron Specific Enolase (NSE) and Other Biochemical Parameters in Iraqi Patients with Ischemic Stroke

“…In cases of ischemic or hemorrhagic stroke neuron specific enolase concentrations can serve as an indication for brain's nerve cells. Immediately following hemorrhagic or ischemic brain injury, cerebrospinal fluid (CSF) and blood show rising NSE levels (11) . Following an ischemic stroke and other brain tissue traumas like intracerebral hemorrhage, head injury and subarachnoid hemorrhage, NSE concentrations rise in the CSF.…”