Relationship Between Mycobacterium tuberculosis Phylogenetic Lineage and Clinical Site of Tuberculosis

Click, Eleanor S.; Moonan, Patrick K.; Winston, Carla A.; Cowan, Lauren S.; Oeltmann, John E.

doi:10.1093/cid/cir788

Cited by 101 publications

(100 citation statements)

References 20 publications

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“…Spoligotype and 12-locus MIRU-VNTR results were used to assign phylogenetic lineage, as described elsewhere. 26 To establish the likelihood of transmission in the USA, we classified cases on the basis of genotype, report date, and epidemiological link. Unlikely transmission was defined as cases of MDR tuberculosis with non-clustered genotypes reported in the same state (with or without extended typing data), and no epidemiological link.…”

Section: Methodsmentioning

confidence: 99%

Transmission of multidrug-resistant tuberculosis in the USA: a cross-sectional study

Moonan¹,

Teeter²,

Salcedo³

et al. 2013

The Lancet Infectious Diseases

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Section: Methodsmentioning

confidence: 99%

Transmission of multidrug-resistant tuberculosis in the USA: a cross-sectional study

Moonan¹,

Teeter²,

Salcedo³

et al. 2013

The Lancet Infectious Diseases

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“…Genotypic definitions-Four major phylogenetic lineages for M. tuberculosis [East African Indian, East Asian (i.e., Beijing strains), Euro-American, Indo-Oceanic], along with speciation of Mycobacterium africanum, were assigned using a set of rules correlating spoligotype with lineages defined by large sequence polymorphisms (LSP) (Click et al, 2012b;Supply et al, 2006). In cases that did not meet the full requirement for phylogenetic lineage assignment based on spoligotype, 12-locus MIRU-VNTR results was used in addition to spoligotype to assign lineage, as described elsewhere (Click et al, 2012b;Shabbeer et al, 2012). We excluded patients with M. africanum or Mycobacterium bovis isolates.…”

Section: Genotyping Methodsmentioning

confidence: 99%

Allopatric tuberculosis host–pathogen relationships are associated with greater pulmonary impairment

Pasipanodya

Moonan

Vecino

et al. 2013

Infection, Genetics and Evolution

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Background-Host pathogen relationships can be classified as allopatric, when the pathogens originated from separate, non-overlapping geographic areas from the host; or sympatric, when host and pathogen shared a common ancestral geographic location. It remains unclear if hostpathogen relationships, as defined by phylogenetic lineage, influence clinical outcome. We sought to examine the association between allopatric and sympatric phylogenetic Mycobacterium tuberculosis lineages and pulmonary impairment after tuberculosis (PIAT).

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“…However, we and others have demonstrated that the various lineages and sublineages of M.tb have distinct clinical and epidemiological phenotypes, including their pathogenicity (11,(39)(40)(41)(42). If bacterial factors associated with pathogenicity are found, it may be possible in the future to determine which patients are more likely to transmit and cause secondary cases among their contacts, enabling implementation of specific strategies directed toward these contacts.…”

Section: Policy Implicationsmentioning

confidence: 97%

Molecular Epidemiology of Tuberculosis in Foreign-Born Persons Living in San Francisco

Suwanpimolkul

Jarlsberg²,

Grinsdale³

et al. 2013

Am J Respir Crit Care Med

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Rationale: In San Francisco, 70% of the tuberculosis cases occur among foreign-born persons, mainly from China, the Philippines, and Mexico. We postulate that there are differences in the characteristics and risk factors for tuberculosis among these populations. Objectives: To determine the clinical, epidemiological and microbiological characteristics of tuberculosis caused by recent infection and rapid evolution in the major groups of foreign-born and the U.S.-born populations. Methods: We analyzed data from a 20-year prospective communitybased study of the molecular epidemiology of tuberculosis in San Francisco. We included all culture-positive tuberculosis cases in the City during the study period. Measurements and Main Results: We calculated and compared incidence rates, clinical and microbiological characteristics, and risk factors for being a secondary case between the various foreign-born and U.S.-born tuberculosis populations. Between 1991 and 2010, there were 4,058 new cases of tuberculosis, of which 1,226 (30%) were U.S.-born and 2,832 (70%) were foreign-born. A total of 3,278 (81%) were culture positive, of which 2,419 (74%) had complete data for analysis. The incidence rate, including the incidence rate of tuberculosis due to recent infection and rapid evolution, decreased significantly in the U.S.-born and the major foreign-born populations. The clinical and microbiological characteristics and the risk factors for tuberculosis due to recent infection differed among the groups. Conclusions: There are differences in the characteristics and the risk factors for tuberculosis due to recent transmission among the major foreign-born and U.S.-born populations in San Francisco. These differences should be considered for the design of targeted tuberculosis control interventions.

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Relationship Between Mycobacterium tuberculosis Phylogenetic Lineage and Clinical Site of Tuberculosis

Abstract: Phylogenetic lineage of M. tuberculosis is associated with the site of tuberculosis disease.

Cited by 101 publications

References 20 publications

Transmission of multidrug-resistant tuberculosis in the USA: a cross-sectional study

Transmission of multidrug-resistant tuberculosis in the USA: a cross-sectional study

Allopatric tuberculosis host–pathogen relationships are associated with greater pulmonary impairment

Molecular Epidemiology of Tuberculosis in Foreign-Born Persons Living in San Francisco

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