Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome

Vecchiet, Jacopo; Cipollone, Francesco; Falasca, Katia; Mezzetti, Andrea; Pizzigallo, Eligio; Bucciarelli, Tonino; Laurentis, Silvana De; Affaitati, Giannapia; Cesare, Domenico De; Giamberardino, Maria Adele

doi:10.1016/s0304-3940(02)01058-3

Cited by 125 publications

(121 citation statements)

References 13 publications

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“…22;23 CFS patients are less able to respond to oxidative stress, such as during strenuous exercise, compared with healthy control subjects. 21 Thus, it is of interest that our exploratory study revealed a general trend of higher basal levels HSP27 in PBMC lysates among CFS patients, and that both HSP27, HSP60 and HSP90 declined following treadmill exercise in contrast to control subjects.…”

Section: Discussionmentioning

confidence: 82%

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Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls

Thambirajah¹,

Sleigh²,

Stiver³

et al. 2008

CIM

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Clin Invest Med 2008; 31 (6): E319-E327. AbstractPurpose: Since physical exertion is known to exacerbate the symptoms of chronic fatigue syndrome (CFS) and metabolic changes and including oxidative stress can modulate heat shock protein (HSP) expression responses, we sought to determine whether HSP expression is altered in CFS patients before and after exercise. Heat shock proteins (HSPs) in peripheral blood mononuclear cells (PBMC) were examined from 6 chronic fatigue syndrome (CFS) patients and 7 controls before and after a standardized treadmill exercise. Basal hsp27 was significantly higher among CFS patients compared to controls, and decreased immediately post-exercise, remaining below basal levels even at 7 days. A similar pattern was observed for HSP60, which gradually decreased in CFS patients but increased in controls post-exercise. These findings suggest an abnormal adaptive response to oxidative stress in CFS, and raise the possibility that HSP profiling may provide a more objective biologic marker for this illness. Methods: HSP27, HSP60, HSP70 and HSP90 expression from 6 CFS patients and 7 age-and sex-matched controls were examined by western blot analysis of peripheral blood mononuclear cells immediately before, after, and at 1 day and 7 days following a standardized treadmill exercise. Results: Basal HSP27 was higher among CFS patients than in controls (0.54 ± 0.13 vs. 0.19 ± 0.06, mean ± SEM; P < 0.01). In addition, these levels in CFS patients decreased immediately post-exercise (0.25 ± 0.09; P < 0.05) and remained below basal levels at day 1 post-exercises (0.18 ± 0.05; P < 0.05). P < 0.05). This declining expression of HSP27 during the post-exercise period among CFS patients was confirmed by one-way ANOVA analysis with repeated measures (P < 0.05). In contrast, HSP27 levels remained relatively constant following exercise among control subjects. Similar patterns of declining ORIGINAL RESEARCH

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Section: Discussionmentioning

confidence: 82%

“…This is supported by previous reports of increased circulating oxidative stress coupled with diminished antioxidant defences in CFS patients compared to healthy individuals. 21 Our exploratory study has several limitations. The number of patients and controls in this preliminary study was small.…”

Section: Discussionmentioning

confidence: 99%

Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls

Thambirajah¹,

Sleigh²,

Stiver³

et al. 2008

CIM

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show abstract

“…[1][2][3] Increase in oxidative stress as a result of an imbalance between free radical production and antioxidant defense has been well documented in several clinical studies. [4] In humans, strenuous exercise promotes the generation of reactive oxygen species (ROS) in the working muscle.…”

Section: Introductionmentioning

confidence: 99%

In-vitro studies on the antioxidant assay profiling of Withania somnifera L. (Ashwagandha) Dunal root: Part 1

Pal¹,

Naika²,

Khanum³

et al. 2011

Pharmacognosy Journal

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a b s t r a c tWithania somnifera Dunal, commonly known as ashwagandha, has been used for centuries in ayurvedic medicine to increase longevity and vitality. Various groups of researchers support its polypharmaceutical uses by confirming anti-inflammatory, immuno-modulatory and antistress properties in the whole plant extract. The present investigation adds up the antioxidant assay profiling in this list. The Ashwagandha root extracts were prepared in different solvents of varied polarity in a sequential fashion. The maximum yield (5.8%) and total polyphenolic compounds (TPC, 88.58 µg GAE/mg extract) were recorded in methanolic fraction. All the extracts were screened for their potential antioxidant activities using tests such as free radical scavenging activity, metal chelation activity, hydroxyl radical scavenging activity, superoxide radical scavenging activity and hydrogen peroxide scavenging activity. Results of study showed methanolic extract as the most potent fraction and a strong correlation could be established with its TPC. Overall, the study suggests that Ashwagandha root extract could be of great use for the preparation of antioxidant rich nutraceuticles to treat various human diseases and its complications. It is quite likely that the antioxidant capacity of plant/root is one of the reasons for its established anti-stress, anti-inflammatory and immunomodulatory properties.

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“…Ischemia, particularly during contractile activity, is associated with increased levels of Reactive Oxygen Species (ROS), such as the superoxide and hydrogen peroxide (H2O2), which are responsible for destructive processes in muscle cells [12][13][14][15]. Ischemia also has important consequences for the cellular metabolic status, with a significantly worsened metabolic and acid-base status when acidosis is predominate in individuals with work-related myalgia [16,17].…”

Section: Introductionmentioning

confidence: 99%

Translating Laboratory Research of BIOCERAMIC Material, Application on Computer Mouse and Bracelet, to Ameliorate Computer Work-Related Musculoskeletal Disorders

Lin

Chan²,

Choy

et al. 2014

Transl Med (sunnyvale)

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We investigated the effects of a room temperature-emitting far infrared ray ceramic material (BIOCERAMIC) on computer work-related pain and coldness. Thirty-two computer users reporting complaints in upper extremities and shoulders were assigned to play 30-cycles of specially-designed computer game. Each subject was provided with a normal and BIOCERAMIC-made mouse for the game on two different days. When using BIOCERAMIC mouse for the computer game, the most significant improvements among the upper extremity complaints were for wrist, finger, forearm, and partially shoulder soreness. Greater differences in surface temperatures of mouse and hand in BIOCERAMIC group were seen. The most significant difference occurred when using both the BIOCERAMIC cover and bracelet were found to reduce pain sensations. It was concluded that pain intensity and disability were significantly reduced after using BIOCERAMIC mouse for the game. The effect remained during follow-up when using BIOCERAMIC mouse cover and bracelet during their usual computer work.

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Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome

Cited by 125 publications

References 13 publications

Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls

Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls

In-vitro studies on the antioxidant assay profiling of Withania somnifera L. (Ashwagandha) Dunal root: Part 1

Translating Laboratory Research of BIOCERAMIC Material, Application on Computer Mouse and Bracelet, to Ameliorate Computer Work-Related Musculoskeletal Disorders

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