Relationship between muscle sympathetic nerve activity and aortic wave reflection characteristics in aerobic- and resistance-trained subjects

Smith, Michael; Buffington, C.A. Tony; Hamlin, Robert L.; Devor, Steven T.

doi:10.1007/s00421-015-3230-9

Cited by 19 publications

(21 citation statements)

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“…activity, oxidative, or endothelial function for this study, which would have helped better interpret our findings. However, we speculate these factors may be implicated in the stiffening of central arteries following maximal exercise (Park et al 2012;Smith and Minson 2012;Smith et al 2015).…”

Section: Limitationsmentioning

confidence: 92%

“…Mechanisms underlying acute maximal exerciseinduced central arterial stiffening in obese individuals are unclear. Increases in sympathetic nerve activity have been associated with central arterial stiffening (Hart et al 2013;Smith et al 2015), and obese individuals have demonstrated increases in sympathetic nerve activity at rest and exaggerated sympathetic reactivity to stress (Kuniyoshi et al 2003;Park et al 2012;Huber and Schreihofer 2016). Obesity-related sympathetic overactivity has also been attributed to oxidative stress (Smith and Minson 2012), which increases postexercise in obese individuals (Vincent et al 2004), thus possibly contributing to central arterial stiffening (Chen et al 2012).…”

Section: Obesity Hemodynamics and Arterial Stiffness At Restmentioning

confidence: 99%

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The effect of acute maximal exercise on postexercise hemodynamics and central arterial stiffness in obese and normal-weight individuals

et al. 2017

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Central arterial stiffness is associated with incident hypertension and negative cardiovascular outcomes. Obese individuals have higher central blood pressure (BP) and central arterial stiffness than their normal‐weight counterparts, but it is unclear whether obesity also affects hemodynamics and central arterial stiffness after maximal exercise. We evaluated central hemodynamics and arterial stiffness during recovery from acute maximal aerobic exercise in obese and normal‐weight individuals. Forty‐six normal‐weight and twenty‐one obese individuals underwent measurements of central BP and central arterial stiffness at rest and 15 and 30 min following acute maximal exercise. Central BP and normalized augmentation index (AIx@75) were derived from radial artery applanation tonometry, and central arterial stiffness was obtained via carotid‐femoral pulse wave velocity (cPWV) and corrected for central mean arterial pressure (cPWV/cMAP). Central arterial stiffness increased in obese individuals but decreased in normal‐weight individuals following acute maximal exercise, after adjusting for fitness. Obese individuals also exhibited an overall higher central BP (P < 0.05), with no exercise effect. The increase in heart rate was greater in obese versus normal‐weight individuals following exercise (P < 0.05), but there was no group differences or exercise effect for AIx@75. In conclusion, obese (but not normal‐weight) individuals increased central arterial stiffness following acute maximal exercise. An assessment of arterial stiffness response to acute exercise may serve a useful detection tool for subclinical vascular dysfunction.

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Section: Limitationsmentioning

confidence: 92%

Section: Obesity Hemodynamics and Arterial Stiffness At Restmentioning

confidence: 99%

The effect of acute maximal exercise on postexercise hemodynamics and central arterial stiffness in obese and normal-weight individuals

et al. 2017

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“…Previous studies have shown that LVH and carotid intima-media thickness are associated with raised BP (38,39). Another possible explanation is that skeletal muscle hypertrophy-related physical activity (e.g., resistance training) could increase arterial stiffness and activate the sympathetic nervous system (40,41), which may elevate BP in humans, according to previous studies (42,43). In addition, the diversity of muscle fiber type may also able to explain the relationships.…”

Section: Resultsmentioning

confidence: 86%

Associations of Body Composition with Blood Pressure and Hypertension

Zhu

Chen

et al. 2018

Obesity

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Objective The present study investigated the associations of body composition, including skeletal muscle and fat mass, with blood pressure (BP) and hypertension. Methods Data from 3,130 participants aged 18 to 80 years were analyzed. Body composition and total skeletal muscle (TSM) were measured or calculated based on dual‐energy x‐ray absorptiometry. Multivariate linear and logistic regression models were used to analyze the associations of TSM, body fat percentage, android to gynoid fat ratio, and leg and arm lean body mass (LBM) with BP and hypertension. The Wald test was used to estimate the differences in the coefficients. Results TSM indices, body fat percentage, and android to gynoid fat ratio were significantly associated with higher odds ratio for prehypertension and hypertension, except for TSM/weight, after controlling for potential confounders. The standardized beta coefficients of arm LBM indices for systolic and diastolic BP were higher than relevant indices of leg LBM. Conclusions Different indices of TSM, especially in arm LBM, were all positively associated with elevated BP, prehypertension, and hypertension in Chinese adults, after considering potential confounding factors, including body fat and fat distribution. Future longitudinal studies are warranted to confirm our findings.

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“…It has already been demonstrated that traditional high intensity strength exercise can acutely compromise flow-mediated vasodilation, reducing NOx levels in sedentary people. 18,19 In such a scenario, reduced nitric oxide bioavailability, combined with the high intensity, could be the result of two factors: increased sympathetic activation during exercise and consequent acetylcholine-mediated vasoconstriction 20 and increased muscle compression of blood vessels when large muscle groups are recruited. 19,20 In the present study, a significant reduction in SOD activity was observed in the LIBFR condition.…”

Section: Discussionmentioning

confidence: 99%

Efeito agudo do exercício de força com restrição do fluxo sanguíneo sobre parâmetros antioxidantes em indivíduos jovens saudáveis

et al. 2018

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Resumo Contexto O treinamento de força com restrição do fluxo sanguíneo (TFRFS) promove adaptações neuromusculares semelhantes às do treinamento de força tradicional utilizando pequenas cargas de treinamento. No entanto, sua repercussão sobre parâmetros antioxidantes e sobre a função vascular precisa ser mais bem compreendida. Objetivos: O objetivo do presente estudo foi investigar o efeito de uma sessão de exercício de força de baixa intensidade com restrição do fluxo sanguíneo, em comparação ao exercício de força de alta intensidade e de baixa intensidade sem restrição do fluxo sanguíneo, sobre os níveis de subprodutos do oxido nítrico e a atividade de enzimas antioxidantes em jovens saudáveis. Métodos: Onze indivíduos jovens realizaram três sessões de exercício de força: baixa intensidade com restrição do fluxo sanguíneo (BIRFS), alta intensidade (AI) ou baixa intensidade (BI). Foram avaliadas a atividade das enzimas antioxidantes catalase (CAT), superóxido dismutase (SOD) e dos metabólitos do óxido nítrico (NOx). Resultados: Não houve modificações nos níveis plasmáticos de NOx nas diferentes condições de exercício (p > 0,05). A atividade da SOD apresentou uma diminuição significativa na condição BIRFS (p < 0,05). A atividade da CAT diminuiu significativamente na condição BI (p < 0.05). Conclusões: A partir do presente estudo sugere-se que uma sessão de treinamento de força de baixa intensidade com restrição do fluxo sanguíneo não reduz a biodisponibilidade do óxido nítrico, bem como não induz desequilíbrio redox em indivíduos jovens saudáveis.

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Relationship between muscle sympathetic nerve activity and aortic wave reflection characteristics in aerobic- and resistance-trained subjects

Abstract: These results confirm previous reports of a positive association between MSNA and AIx in young male resistance-trained subjects. Furthermore, RT is associated with increased arterial stiffness and elevated sympathetic outflow.

Cited by 19 publications

References 50 publications

The effect of acute maximal exercise on postexercise hemodynamics and central arterial stiffness in obese and normal-weight individuals

The effect of acute maximal exercise on postexercise hemodynamics and central arterial stiffness in obese and normal-weight individuals

Associations of Body Composition with Blood Pressure and Hypertension

Efeito agudo do exercício de força com restrição do fluxo sanguíneo sobre parâmetros antioxidantes em indivíduos jovens saudáveis

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