Relationship between MTA1 and spread through air space and their joint influence on prognosis of patients with stage I-III lung adenocarcinoma

Liu, Yangyang; Chen, Donglai; Xie, Qiu; Duan, Shanzhou; Zhang, Yongsheng; Li, Feng; Chen, Chang; Zhou, Yongzhao; Chen, Yongbing

doi:10.1016/j.lungcan.2018.07.040

Cited by 30 publications

(33 citation statements)

References 27 publications

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“…17,18 Positive STAS was observed to be associated with old age (>65 years), male sex, smoking, abnormal serum carcinoembryonic antigen level, larger tumor size, nonlepidic (micropapillary/solid) predominant, cribriform component, moderate/poor differentiation, visceral pleural invasion, lymphovascular invasion, presence of nodal and distant metastasis and higher T, N and pathological stage. [16][17][18][19][20][21] In survival analyses, STAS was an independent risk factor for worse recurrence-free survival (RFS) and overall survival (OS). 17,18,20 Similar results were identified in particular studies of stage I and stage III (N2) ADC.…”

Section: Clinicopathologic Features and Prognosis Of Stasmentioning

confidence: 98%

<p>Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review</p>

Meng¹,

Yu²,

Gao³

et al. 2020

CMAR

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Background: Spread through air spaces (STAS) is a spreading phenomenon of lung cancers, which is defined as tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. To date, several articles have reviewed the studies concerning the significance of STAS; however, most articles focused on the prognosis without summarizing the significance of STAS on other aspects. In this review, we comprehensively summarized the current literature related to STAS, so as to explore the clinical significance of STAS from multiple perspectives. Main Body: This section provided a comprehensive overview of the significance of STAS from multiple perspectives and summarized current controversies and challenges in the diagnosis and clinical application. Conclusion: STAS is a conspicuous spreading phenomenon of lung cancers indicating worse prognosis; nevertheless, the treatment strategy for patients with STAS remains to be discussed. Further studies are needed to elaborate whether a STAS-positive patient who underwent limited resection needs a second operation or postoperative adjuvant treatment. Meanwhile, the internal mechanism of STAS formation is largely undiscovered. Whether the capability of detachment-migration-reattachment in STAS tumor cells is achieved at the time of primary tumorigenesis or in the progress of tumor development needs to be studied, and the related signal pathways or genetic alterations need to be explored. With this information, it may be possible to improve the prognosis of patients with STAS-positive lung cancers.

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Section: Clinicopathologic Features and Prognosis Of Stasmentioning

confidence: 98%

<p>Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review</p>

Meng¹,

Yu²,

Gao³

et al. 2020

CMAR

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“…Based on current research, STAS has important significance as a reference in patient prognosis. It was reported that MTA1 might provide potential information on the mechanism of STAS . However, further studies are still needed to identify the molecular characteristics and mechanisms underlying STAS.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that MTA1 might provide potential information on the mechanism of STAS. 11 However, further studies are still F I G U R E 2 Kaplan-Meier survival analysis of recurrence-free survival (RFS) and overall survival (OS) according to spread through air spaces (STAS), Twist and Slug in patients with lung adenocarcinoma. A, RFS in patients with vs without STAS (P < .001).…”

Section: Discussionmentioning

confidence: 99%

“…STAS was associated with invasive characteristics, such as lymphovascular invasion, visceral pleura invasion and invasive patterns . It was reported that metastasis‐associated protein 1 (MTA1) might provide potential information on the mechanism of STAS . However, further studies are still needed to identify the molecular characteristics and mechanisms underlying STAS.…”

Section: Introductionmentioning

confidence: 99%

“…2,3,[5][6][7][8][9][10] It was reported that metastasis-associated protein 1 (MTA1) might provide potential information on the mechanism of STAS. 11 However, further studies are still needed to identify the molecular characteristics and mechanisms underlying STAS.…”

Section: Introductionmentioning

confidence: 99%

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Relevance and prognostic ability of Twist, Slug and tumor spread through air spaces in lung adenocarcinoma

Liu

Sun

et al. 2020

Cancer Medicine

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Background Tumor spread through air spaces (STAS) is a novel pathologic characteristic in lung adenocarcinomas that indicates invasive tumor behavior. We aimed to explore the relationship between Twist, Slug and STAS in lung adenocarcinoma and to investigate the potential relationship between epithelial‐mesenchymal transition (EMT) and STAS. Materials and methods Our study retrospectively analyzed 115 patients with resected lung adenocarcinomas to evaluate the relationship between Twist, Slug and STAS. STAS was diagnosed using hematoxylin‐eosin (H&E) staining. Immunohistochemistry was used to evaluate the expression levels of Slug and Twist. Results In this study, 56 (48.7%) patients had STAS, 40 (34.8%) patients had Slug overexpression, and 28 (24.3%) patients had Twist overexpression. Patients with either STAS or Slug and Twist overexpression experienced poor recurrence‐free survival (RFS) and overall survival (OS). There were significant associations between Twist overexpression, Slug overexpression and the presence of STAS. The logistic model further revealed that pathological stage, Twist overexpression and Slug overexpression were independent risk factors for STAS. A multivariate analysis that contained Twist, Slug, pathologic stage and STAS, showed that pathologic stage and STAS were independent prognostic factors for poor RFS and OS. Another multivariate model that contained Twist, Slug and pathologic stage, showed that pathologic stage, Twist overexpression and Slug overexpression were independent risk factors for poor RFS and OS. In the cohort with STAS, the multivariate analysis showed that pathologic stage and Twist overexpression were independent risk factors for poor survival. The subgroup analysis showed that patients with both Slug overexpression and Twist overexpression with STAS received a poor prognosis. Conclusions STAS, Slug and Twist were correlated with poor RFS and OS in resected lung adenocarcinomas. Additionally, STAS was correlated with the overexpression of Twist and Slug, which could potentially provide information on the mechanism of STAS.

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Metastasis‐associated 1 localizes to the sarcomeric Z‐disc and is implicated in skeletal muscle pathology

Xue,

Han,

Sun

et al. 2024

Cytoskeleton

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Metastasis‐associated 1 (MTA1), a subunit of the nucleosome remodeling and histone deacetylation (NuRD) corepressor complex, was reported to be expressed in the cytoplasm of skeletal muscles. However, the exact subcellular localization and the functional implications of MTA1 in skeletal muscles have not been examined. This study aims to demonstrate the subcellular localization of MTA1 in skeletal muscles and reveal its possible roles in skeletal muscle pathogenesis. Striated muscles (skeletal and cardiac) from C57BL/6 mice of 4–5 weeks were collected to examine the expression of MTA1 by Western blotting and immunohistochemistry. Immunofluorescence and immunoelectron microscopy were performed for MTA1, α‐actinin (a Z‐disc marker protein), and SMN (survival of motor neuron) proteins. Gene Expression Omnibus (GEO) data sets were analyzed using the GEO2R online tool to explore the functional implications of MTA1 in skeletal muscles. MTA1 expression was detected by Western blotting and immunohistochemistry in skeletal and cardiac muscles. Subcellular localization of MTA1 was found in the Z‐disc of sarcomeres, where α‐actinin and SMN were expressed. Data mining of GEO profiles suggested that MTA1 dysregulation is associated with multiple skeletal muscle defects, such as Duchenne muscular dystrophy, Emery‐Dreifuss muscular dystrophy, nemaline myopathy, and dermatomyositis. The GEO analysis also showed that MTA1 expression gradually decreased with age in mouse skeletal muscle precursor cells. The subcellular localization of MTA1 in sarcomeres of skeletal muscles implies its biological roles in sarcomere structures and its possible contribution to skeletal muscle pathology.

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Relationship between MTA1 and spread through air space and their joint influence on prognosis of patients with stage I-III lung adenocarcinoma

Cited by 30 publications

References 27 publications

<p>Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review</p>

<p>Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review</p>

Relevance and prognostic ability of Twist, Slug and tumor spread through air spaces in lung adenocarcinoma

Metastasis‐associated 1 localizes to the sarcomeric Z‐disc and is implicated in skeletal muscle pathology

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