Relationship Between Mood, Thinking, and Walking: A Systematic Review Examining Depressive Symptoms, Executive Function, and Gait

Patience, James; Lai, Ka Sing Paris; Russell, Elizabeth M.; Vasudev, Akshya; Montero‐Odasso, Manuel; Burhan, Amer M.

doi:10.1016/j.jagp.2019.07.007

Cited by 31 publications

(28 citation statements)

References 45 publications

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“…Zhang et al 37 reported that the anterior thalamic radiation, prefrontal corticopontine tracts, thalamo‐striate, and striate‐striate tracts converge in the ALIC. Thus, the ALIC contains a large number of WM fiber tracts connecting neurons in the frontal‐subcortical neural circuits, 38 and they play critical roles in emotion stability, motivation, decision‐making, and executive function in MDD 39 . Our study further demonstrated functional abnormalities in the ALIC with decreased FC between the ALIC and temporal GM regions in MDD.…”

Section: Discussionsupporting

confidence: 60%

Desynchronized Functional Activities Between Brain White and Gray Matter in Major Depression Disorder

Zhang

Kong

Liu

et al. 2020

Magnetic Resonance Imaging

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Background Alterations in gray matter (GM) have been recognized as playing an important role in the neurobiological mechanism underlying major depressive disorder (MDD) and antidepressant responses. However, little is known about white matter (WM) connectivity in MDD, leaving an incomplete understanding of the pathophysiology of the disorder. Purpose To examine the functional connectivity (FC) of WM, GM, and WM‐GM in MDD patients and explore the relationship between FC and antidepressant response. Study Type Longitudinal study. Subjects In all, 129 MDD patients and 89 healthy controls (HC). Field Strength/Sequence Whole‐brain blood oxygen level‐dependent (BOLD) single‐shot echo planar imaging was acquired at 3.0T. Assessment At baseline, all participants received Hamilton depression rating scale (HAMD) assessment and an fMRI scan. After 2‐ and 8‐week antidepressant treatment, patients completed the HAMD again. The HAMD reductive rate of 2‐ and 8‐weeks were calculated. Statistical Tests The comparisons of age, education, HAMD scores, and FC values (false discovery rate correction) between patients and controls were calculated with a two‐sample t‐test. The chi‐square test was employed to compare the differences of gender between these two groups. Correlations between FC and HAMD, as well as the reductive rate of HAMD, were analyzed with Pearson or Spearman correlation. Receiver operator curve analysis was performed to predict the antidepressant response. Results Compared to HC, MDD patients exhibited widespread decreases in FC of WM‐GM. Furthermore, 28 GM regions and 11 WM bundles had lower connectivity in MDD patients. At baseline, four FC of WM‐GM showed negative correlations with the HAMD scores. Six FC of WM‐GM correlated with the 2‐week reductive rate of HAMD. Moreover, FC in GM, WM, and WM‐GM also exhibited significantly positive correlations with an 8‐week reductive rate of HAMD. Data Conclusion The FC of WM‐GM was decreased in MDD and may play a role in its pathophysiology and antidepressant responses. Level of Evidence 2. Technical Efficacy Stage 2.

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Section: Discussionsupporting

confidence: 60%

Desynchronized Functional Activities Between Brain White and Gray Matter in Major Depression Disorder

Zhang

Kong

Liu

et al. 2020

Magnetic Resonance Imaging

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“…First, there is no question about the high risk of falls in older people and the validity of paradigms linking shared brain pathways in mobility, falls and cognition. 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 Key to this discussion is the association between specific gray matter networks, normal pace walking speed, dual-task costs and different cognitive domains 76 and the strong evidence that shared neural systems responsible for gait speed and processing speed are indeed subjected to age and dementia-associated pathological changes. 83 On the other hand, the extensive work on the Motoric Cognitive Risk Syndrome (MCR) defined as a pre-dementia syndrome characterized by subjective cognitive complaints and slow gait, the association between gait decline and mild cognitive impairment (MCI) and the cognitive and motor trajectories in their path to dementia are obligated topics in this discussion.…”

Section: Discussionmentioning

confidence: 99%

Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young

Calderón‐Garcidueñas

Torres-Solorio

Kulesza

et al. 2020

Environmental Research

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To determine whether gait and balance dysfunction are present in young urbanites exposed to fine particular matter PM 2.5 ≥ annual USEPA standard, we tested gait and balance with Tinetti and Berg tests in 575 clinically healthy subjects, age 21.0±5.7y who were residents in Metropolitan Mexico City, Villahermosa and Reynosa. The Montreal Cognitive Assessment was also applied to an independent cohort n:76, age 23.3± 9.1y. In the 575 cohort, 75.4% and 34.4% had abnormal total Tinetti and Berg scores and high risk of falls in 17.2% and 5.7% respectively. BMI impacted negatively Tinetti and Berg performance. Gait dysfunction worsen with age and males performed worse than females. Gait and balance dysfunction were associated with mild cognitive impairment MCI (19.73%) and dementia (55.26%) in 57/76 and 19 cognitively intact subjects had gait and balance dysfunction. Seventy-five percent of urbanites exposed to PM 2.5 had gait and balance dysfunction. For MMC residents-with historical documented Alzheimer disease (AD) and CSF abnormalities, these findings suggest Alzheimer Continuum is in progress. Early development of a Motoric Cognitive Risk Syndrome ought to be considered in city dwellers with normal cognition and gait dysfunction. The AD research frame in PM 2.5 exposed young urbanites should include gait and balance measurements. Multicity teens and young adult cohorts are warranted for quantitative gait and balance measurements and neuropsychological and brain imaging studies in high vs low PM 2.5 exposures. Early identification of gait and balance impairment in young air pollution-exposed urbanites would facilitate multidisciplinary prevention efforts for modifying the course of AD.

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“…Also, depression was found to increase the risk of POCD and delirium ( Tully et al, 2010 ; Oldham et al, 2019 ). Geriatric depression seems to be related with cognitive deficits in general ( Brailean et al, 2017 ), especially in executive functions ( Patience et al, 2019 ). Moreover, depression is known to be related to cognitive decline in Alzheimer’s disease (AD) ( Butters et al, 2008 ; Byers and Yaffe, 2011 ) and Parkinson’s disease (PD) ( Stefanova et al, 2006 ; Santangelo et al, 2009 ; Barone et al, 2011 ; de la Riva et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Impaired Executive Function and Depression as Independent Risk Factors for Reported Delirium Symptoms: An Observational Cohort Study Over 8 Years

Mychajliw

Herrmann

Suenkel

et al. 2021

Front. Aging Neurosci.

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BackgroundAcute medical illnesses, surgical interventions, or admissions to hospital in older individuals are frequently associated with a delirium. In this cohort study, we investigated the impact of specific cognitive domains and depression before the occurrence of delirium symptoms in an 8-year observation of older non-hospitalized individuals.MethodsIn total, we included 807 participants (48–83 years). Deficits in specific cognitive domains were measured using the CERAD test battery, and depressive symptoms were measured using Beck Depression Inventory and the Geriatric Depression Scale (GDS) before the onset of a delirium. Delirium symptoms were retrospectively assessed by a questionnaire based on the established Nursing Delirium Screening Scale.ResultsFifty-eight of eight hundred seven participants (7.2%) reported delirium symptoms over the 8-year course of the study. Sixty-nine percent (n = 40) of reported delirium symptoms were related to surgeries. In multivariate regression analysis, impaired executive function was an independent risk factor (p = 0.034) for the occurrence of delirium symptoms. Furthermore, age (p = 0.014), comorbidities [captured by the Charlson Comorbidity Index (CCI)] (p < 0.001), and depression (p = 0.012) were significantly associated with reported delirium symptoms.ConclusionEspecially prior to elective surgery or medical interventions, screening for impaired executive function and depression could be helpful to identify patients who are at risk to develop delirium symptoms.

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Relationship Between Mood, Thinking, and Walking: A Systematic Review Examining Depressive Symptoms, Executive Function, and Gait

Cited by 31 publications

References 45 publications

Desynchronized Functional Activities Between Brain White and Gray Matter in Major Depression Disorder

Desynchronized Functional Activities Between Brain White and Gray Matter in Major Depression Disorder

Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young

Impaired Executive Function and Depression as Independent Risk Factors for Reported Delirium Symptoms: An Observational Cohort Study Over 8 Years

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