Relationship between monocytes to lymphocytes ratio and axial spondyloarthritis

Huang, Yung-Cheng; Deng, Weiming; Zheng, Shaoling; Feng, Fan; Huang, Zhixiang; Huang, Q.; Guo, Xin; Huang, Zhengping; Huang, Xiaoyu; Pan, Xia; Li, Tianwang

doi:10.1016/j.intimp.2018.02.008

Cited by 73 publications

(73 citation statements)

References 23 publications

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“…The elevated MLR level may be a result of the increased monocyte counts or/and decreased lymphocyte counts. In the present study, the MLR levels of SAP patients were higher than non-SAP patients (0.53 vs. 0.30, P < 0.001; Table 1 ), and the MLR level of all AIS patients was higher than the non-stroke control patients in a previous study of axial spondyloarthritis (0.31 vs. 0.20, respectively; Table 1 ) ( 24 ). This could be attributed to the inflammatory response led by the occurrence of stroke.…”

Section: Discussionsupporting

confidence: 52%

“…Monocyte-to-lymphocyte ratio (MLR) is the absolute monocyte count divided by the absolute lymphocyte count and has been demonstrated to be a novel hematological and inflammatory parameter. MLR is associated with various diseases, such as community-acquired pneumonia, axial spondylarthritis, and coronary angiography, as well as the systemic inflammatory response, which reflects the abnormal immune status of diseases ( 22 – 24 ); however, the relationship between SAP and MLR remains unclear. In 2017, a study found that lymphocyte-to-monocyte ratios (LMRs) at admission were lower in AIS patients with pneumonia or urinary tract infection compared with patients without infections ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

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High Monocyte-To-Lymphocyte Ratio Is Associated With Stroke-Associated Pneumonia

et al. 2020

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Purpose: Stroke-associated pneumonia (SAP), a common complication in acute ischemic stroke (AIS) patients, is associated with poor prognosis after AIS. Inflammation plays an important role in the development of SAP. In this study, we aimed to explore the association between the monocyte-to-lymphocyte ratio (MLR) and SAP in AIS patients. Methods: We continuously enrolled 972 AIS patients. SAP was diagnosed by two trained neurologists and confirmed by radiography, meeting the modified Centers for Disease Control and Prevention criteria. MLR values were measured for all participants, and all patients were evenly classified into three tertiles according to the MLR levels. We used the values that Youden's index max points corresponded to represent the optimal cutoffs, which represented the balance in sensitivity and specificity. Results: 104 (10.7%) patients were diagnosed with SAP. SAP patients showed a significant increased ( P < 0.001) MLR when compared with non-SAP. The optimal cutoff points of MLR were (T1) <0.2513, (T2) 0.2513–0.3843, and (T3) > 0.3843. The incidence of SAP was significantly higher in the third MLR tertile than the first and second MLR tertiles (21.7 vs. 4 vs. 6.5%, respectively, P < 0.001). After adjusting for confounding and risk factors, multivariate regression analysis showed that the third MLR tertile was an independent variable predicting the occurrence of SAP (odds ratio = 3.503, 95%CI = 1.066–11.515, P = 0.039). Conclusions: Our study showed that higher MLR was significantly associated with SAP in AIS patients. MLR is beneficial for clinicians to recognize patients with a high risk of SAP at an early stage and is an effective way to improve clinical care of SAP patients. Higher MLR could be a helpful and valid biomarker for predicting SAP in clinical practice.

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Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

High Monocyte-To-Lymphocyte Ratio Is Associated With Stroke-Associated Pneumonia

et al. 2020

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“…The optimal cutoff value for the MLR for AS was 0.279, with a sensitivity of 47.2% and a specificity of 91.2%, while values for the NLR were 2.156, 57.3%, and 88.9%, respectively. The AUC and sensitivity of the MLR and NLR were lower than reported previously, 11 which could be explained by differences in inclusion criteria. An explanation for the observed relationship between higher levels of NLR and MLR with AS is not yet clear.…”

Section: Discussioncontrasting

confidence: 77%

Clinical significance of the monocyte:lymphocyte ratio for ankylosing spondylitis patients with thoracolumbar kyphotic deformities

2020

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This study aimed to determine the clinical significance of the monocyte:lymphocyte ratio (MLR) in ankylosing spondylitis (AS) patients with thoracolumbar kyphotic deformity. Methods: Ninety AS patients and 45 healthy controls were retrospectively enrolled. AS patients were divided into thoracolumbar kyphotic deformity (AS deformity) and spine normal (AS normal) groups. Blood parameters including C-reactive protein and erythrocyte sedimentation rate were determined. Receiver operating characteristic (ROC) curves and binary logistic regression analysis were conducted. Results: Counts of white blood cells, neutrophils, and monocytes, and the neutrophil:lymphocyte ratio, platelet:lymphocyte ratio, and MLR were significantly higher in the AS than the control group. ROC curve results showed that the MLR yielded a higher area under the curve (AUC) value than other parameters, compared with controls. The MLR and monocyte count were higher in the AS deformity group than the AS normal group. ROC curve results indicated that the MLR yielded a higher AUC value than other parameters, compared with the AS normal group. Logistic regression suggested that the MLR was an independent predictor for thoracolumbar kyphotic deformity. Conclusions: The MLR was elevated in AS patients, and was shown to be an independent predictor for thoracolumbar kyphotic deformity.

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“…It has been shown that the monocyte/lymphocyte ratio (MLR), the platelet/lymphocyte ratio (PLR), and the neutrophil/lymphocyte ratio (NLR) are associated with many autoimmune and rheumatic diseases [5], and the PLR and NLR can be used for assessing inflammatory response and monitoring disease activity in patients with systemic lupus erythematosus (SLE) [6] and also in assessing disease activity in patients with rheumatoid arthritis (RA) [7]. Also, the MLR can be used to evaluate disease severity in axial spondyloarthritis [8]. Sahin et al [9] reported that the mean platelet volume (MPV) was negatively correlated with ESR and CRP in some rheumatic diseases and negatively correlated with disease activity in ankylosing spondylitis and rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

The C-Reactive Protein/Albumin Ratio and Complete Blood Count Parameters as Indicators of Disease Activity in Patients with Takayasu Arteritis

et al. 2019

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Background This study aimed to evaluate the ratio of C-reactive protein (CRP) to albumin, inflammatory markers, and parameters from the complete blood count (CBC) in patients with Takayasu arteritis and the association with disease activity. Material/Methods A retrospective study included thirty-two patients with Takayasu arteritis and 32 healthy controls. Clinical and demographic characteristics of patients with Takayasu arteritis were recorded at baseline, before medication and on remission. Similar data were obtained for the controls at recruitment. Remission was defined as more than six months of stable disease without new vascular lesions in patients who previously had active disease. Kerr’s criteria were used to define active Takayasu arteritis. Results In patients with Takayasu arteritis, the erythrocyte sedimentation rate (ESR), CRP, CRP/albumin ratio, red cell distribution width (RDW), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) were significantly higher, and albumin and MPV were significantly lower compared with controls. The ESR, CRP, CRP/albumin ratio, NLR, PLR, and MLR were decreased in remission, whereas MPV was increased. CRP and the CRP/albumin ratio were positively correlated and albumin and MPV were negatively correlated with disease activity. The CRP/albumin ratio had the highest correlation with disease activity in Takayasu arteritis. The CRP/albumin ratio, RDW, NLR, PLR, and MLR were positively correlated with CRP and ESR. Conclusions The CRP/albumin ratio, RDW, NLR, PLR, MLR, and MPV were markers of remission of active disease, and the CRP/albumin ratio, total albumin, and MPV were markers of disease activity in Takayasu arteritis.

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Relationship between monocytes to lymphocytes ratio and axial spondyloarthritis

Cited by 73 publications

References 23 publications

High Monocyte-To-Lymphocyte Ratio Is Associated With Stroke-Associated Pneumonia

High Monocyte-To-Lymphocyte Ratio Is Associated With Stroke-Associated Pneumonia

Clinical significance of the monocyte:lymphocyte ratio for ankylosing spondylitis patients with thoracolumbar kyphotic deformities

The C-Reactive Protein/Albumin Ratio and Complete Blood Count Parameters as Indicators of Disease Activity in Patients with Takayasu Arteritis

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