Relationship between miRNA and ferroptosis in tumors

Dai, Shang-Ming; Li, Feng‐Jiao; Long, Hui-Zhi; Zhou, Ziwei; Luo, Hongyu; Xu, Shuo-Guo; Gao, Lichen

doi:10.3389/fphar.2022.977062

Cited by 14 publications

(11 citation statements)

References 169 publications

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“…This is the case for breast cancer, which was treated with Metformin to target the mir-324-3p/GPX4 axis in a pro-ferroptotic manner [ 110 ]. In addition, Icariside II is a natural active flavonoid that affects this axis and promotes ferroptosis in renal cell carcinoma [ 111 ]. Curcumenol is another natural molecule able to act as a ferroptosis inducer via the lncRNA H19/miR-19b-3p/FTH1 axis.…”

Section: Role Of Micrornas In Ferroptosismentioning

confidence: 99%

Modulation of Ferroptosis by microRNAs in Human Cancer

Velkova

Pasino

Khalid

et al. 2023

JPM

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Ferroptosis is a cell death pathway triggered by an imbalance between the production of oxidants and antioxidants, which plays an emerging role in tumorigenesis. It is mainly regulated at three different levels including iron metabolism, the antioxidant response, and lipid metabolism. Epigenetic dysregulation is a “hallmark” of human cancer, with nearly half of all human cancers harboring mutations in epigenetic regulators such as microRNA. While being the crucial player in controlling gene expression at the mRNA level, microRNAs have recently been shown to modulate cancer growth and development via the ferroptosis pathway. In this scenario, some miRNAs have a function in upregulating, while others play a role in inhibiting ferroptosis activity. The investigation of validated targets using the miRBase, miRTarBase, and miRecords platforms identified 13 genes that appeared enriched for iron metabolism, lipid peroxidation, and antioxidant defense; all are recognized contributors of tumoral suppression or progression phenotypes. This review summarizes and discuss the mechanism by which ferroptosis is initiated through an imbalance in the three pathways, the potential function of microRNAs in the control of this process, and a description of the treatments that have been shown to have an impact on the ferroptosis in cancer along with potential novel effects.

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Section: Role Of Micrornas In Ferroptosismentioning

confidence: 99%

Modulation of Ferroptosis by microRNAs in Human Cancer

Velkova

Pasino

Khalid

et al. 2023

JPM

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“…In addition to the enhanced glycolysis process, the enhancement of glutamine decomposition is also a characteristic of tumor cells, and GLS is a key enzyme in the glutamine decomposition process. GLS can decompose glutamine (Gln) into glutamic acid (Glu), and then Glu generates α-ketoglutarate (α-KG) under the action of glutamic acid transaminase 1 (GOT1) [ 89 , 90 ]. The α-KG is an important intermediate product of the tricarboxylic acid (TCA) cycle, and the increase of α-KG can promote the TCA cycle to produce more energy, nucleotides, lipids, amino acids and other substances required by cells, which is conducive to cell growth and survival [ 91 – 93 ].…”

Section: Role Of Mir-1-3p In Tumor Occurrence and Developmentmentioning

confidence: 99%

“…First, they have poor specificity and a rather large number of targets. Second, the mechanism of targeting miR-1-3p is also unclear [ 90 ]. Therefore, in order to better target the target molecule, gene drugs will become a hot spot for future research.…”

Section: Approaches To Targeting Mir-1-3pmentioning

confidence: 99%

The important role of miR-1-3p in cancers

Dai,

Li,

et al. 2023

J Transl Med

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Cancer is a malignant tumor that seriously threatens human life and health. At present, the main treatment methods include surgical resection, chemotherapy, radiotherapy, and immunotherapy. However, the mechanism of tumor occurrence and development is complex, and it produces resistance to some traditional treatment methods, leading to treatment failure and a high mortality rate for patients. Therefore, exploring the molecular mechanisms of tumor occurrence, development, and drug resistance is a very important task. MiRNAs are a type of non-coding small RNA that regulate a series of biological effects by binding to the 3′-UTR of the target mRNA, degrading the mRNA, or inhibiting its translation. MiR-1-3p is an important member of them, which is abnormally expressed in various tumors and closely related to the occurrence and development of tumors. This article introduces miR-1-3p from multiple aspects, including its production and regulation, role in tumor occurrence and development, clinical significance, role in drug resistance, and approaches for targeting miR-1-3p. Intended to provide readers with a comprehensive understanding of the important role of miR-1-3p in tumors. Graphical Abstract

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“…MiRNAs, short single-stranded RNAs, regulate ferroptosis by targeting essential regulators involved in this process, such as GPX4 and acyl-CoA synthetase long-chain family member 4 (ACSL4). Through binding to specific mRNA sequences, miRNAs influence the expression of these proteins ( Wen et al, 2015 ), thereby contributing to the regulation of ferroptosis ( Tabnak et al, 2021 ; Dai et al, 2022 ). Conversely, lncRNAs and circRNAs impact ferroptosis by acting as competitive endogenous RNAs (ceRNAs) or sponges for miRNAs ( Zhou et al, 2022a ; Dabbaghi et al, 2023 ; Tabnak et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis-related exosomal non-coding RNAs: promising targets in pathogenesis and treatment of non-malignant diseases

Zhang,

Xie

2024

Front. Cell Dev. Biol.

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Ferroptosis, an iron-dependent form of programmed cell death, introduces a novel perspective on cellular demise. This study investigates the regulatory network of exosomal non-coding RNAs (ncRNAs), including miRNAs, circRNAs, and lncRNAs, in ferroptosis modulation. The primary goal is to examine the pathological roles of ferroptosis-related exosomal ncRNAs, particularly in ischemic reperfusion injuries. The research reveals intricate molecular interactions governing the regulatory interplay between exosomal ncRNAs and ferroptosis, elucidating their diverse roles in different non-malignant pathological contexts. Attention is given to their impact on diseases, including cardiac, cerebral, liver, and kidney ischemic injuries, as well as lung, wound, and neuronal injuries. Beyond theoretical exploration, the study provides insights into potential therapeutic applications, emphasizing the significance of mesenchymal stem cells (MSCs)-derived exosomes. Findings underscore the pivotal role of MSC-derived exosomal ncRNAs in modulating cellular responses related to ferroptosis regulation, introducing a cutting-edge dimension. This recognition emphasizes the importance of MSC-derived exosomes as crucial mediators with broad therapeutic implications. Insights unveil promising avenues for targeted interventions, capitalizing on the diverse roles of exosomal ncRNAs, providing a comprehensive foundation for future therapeutic strategies.

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Relationship between miRNA and ferroptosis in tumors

Cited by 14 publications

References 169 publications

Modulation of Ferroptosis by microRNAs in Human Cancer

Modulation of Ferroptosis by microRNAs in Human Cancer

The important role of miR-1-3p in cancers

Ferroptosis-related exosomal non-coding RNAs: promising targets in pathogenesis and treatment of non-malignant diseases

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