Relationship between miR-92b expression and hypertension, the degree of heart disease and cerebral hemorrhage

Abstract

Objective: To delve into the correlation between miR-92b expression in peripheral plasma and hypertension, heart disease and cerebral hemorrhage. Methods: We enrolled 204 patients hospitalized in our institution from March 2016 to May 2017, including patients with hypertension (group B), hypertensive left ventricular hypertrophy (HTN-LVH) (group C), HTN-LVH complicated heart failure (group D), with 68 cases each group, and recruited another 60 healthy volunteers as control group (group A). Our team compared miR-92b level in peripheral plasma, and ultrasound indexes among the four groups and inquired into their correlation. The patients were followed up to assay miR-92b level in the peripheral plasma, cerebral edema volume and cerebral hematoma volume before and after treatment. Results: (1) In contrast to group B, the LVDs and LVMI in group C, D waxed, whereas LVEF and E/A waned (P<0.05). In contrast to group C, group D owned increased LVDs and LVMI, and decreased LVEF (all P<0.05). (2) In contrast to group A, miR-92b expression decreased in groups B, C and D, among which group D were the lowest and group B were the highest (all P<0.05). (3) miR-92b held negative relationship with SBP, DBP, LVDd and LVMI (all P<0.001), and had positive link with LVEF (r=0.649, P<0.001). (4) In contrast to before treatment, miR-92b expression in plasma was up-regulated after treatment (P<0.05). miR-92b level in plasma after treatment possessed negative association with brain edema volume and hematoma volume (P<0.001), and no correlation with the edema/hematoma ratio. Conclusion: miR-92b expression in peripheral plasma of patients with hypertension, myocardial hypertrophy and cerebral hemorrhage is down-regulated. miR-92b probably harbors a defensive impact and participates in the pathophysiological process of hypertension, heart disease and cerebral hemorrhage.