Relationship between microRNA expression profiling and gestational diabetes: A systematic review

Borrero, Ana María Arboleda; García‐Perdomo, Herney Andrés; Mosquera, Mildrey

doi:10.1016/j.obmed.2023.100487

Cited by 1 publication

(2 citation statements)

References 81 publications

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“… 60 But in GDM, some miRNAs like miR‐222, miR‐132, miR‐29a, miR‐30d, miR‐96, and miR‐185 were underexpressed. 24 , 61 , 62 , 63 , 64 Animal studies showed that the increase of miR‐26a through the insulin signaling pathway is involved in the increase of glucose absorption. A study on diabetic mice showed that miR‐26a improves insulin resistance and glucose balance and increases the quality of bone formation, and administration of miR‐26a to diabetic mice promotes phosphorylation of downstream mediators in the insulin signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…miR‐33a affects INS‐1 (Gene encoding insulin 1) and insulin production by targeting ABCA1 (ATP‐binding cassette transporter) 60 . But in GDM, some miRNAs like miR‐222, miR‐132, miR‐29a, miR‐30d, miR‐96, and miR‐185 were underexpressed 24,61–64 . Animal studies showed that the increase of miR‐26a through the insulin signaling pathway is involved in the increase of glucose absorption.…”

Section: Discussionmentioning

confidence: 99%

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Are miR‐26a and miR‐26b microRNAs potent prognostic markers of gestational diabetes?

Ghaneialvar,

Mohseni,

Kenarkoohi

et al. 2024

Health Science Reports

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BackgroundGestational diabetes mellitus is a common public health problem, accompanied by complications for the mother and fetus. So, introducing new biomarkers to identify early diabetes is essential. As serum miRNAs are potentially appropriate markers, we investigated miR‐26a and miR‐26b expression levels in pregnant women with and without gestational diabetes.MethodDemographic and clinical characteristics of 40 gestational diabetic patients and 40 healthy controls were assessed. The expression level of miR‐26a and miR‐26b microRNAs was measured by real‐time PCR. Statistical analysis was done with GraphPad Prism software (version 8.4.3).ResultThe findings of this study showed that the expression level of miR‐26a and miR‐26b increased in women with gestational diabetes compared with healthy pregnant women, but the increase in expression was only significant for miR‐26a (p < 0.05).ConclusionAccording to the statistical and ROC curves, we suggest miR‐26a as a potential biomarker for the early diagnosis of gestational diabetes mellitus.

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