Relationship between methylation status of vitamin D-related genes, vitamin D levels, and methyl-donor biochemistry

Beckett, Emma L.; Duesing, Konsta; Martin, Charlotte; Jones, Patrice; Furst, John; King, Katrina; Niblett, Suzanne; Yates, Zoë; Veysey, Martin; Lucock, Mark

doi:10.1016/j.jnim.2016.04.010

Cited by 35 publications

(47 citation statements)

References 38 publications

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“…In the same study no differential methylation was found for CYP27B1 (Zhou et al, 2014). Beckett et al (2016) In another study, dietary sources of vitamin D (fatty fish and vitamin D-fortified low-fat dairy products) was associated to vitamin D status among older Swedish women during winter (Burgaz, Åkesson, Öster, Michaëlsson, Wolk, 2007). In many regions, serum 25(OH)D levels are reported to be lower in dark skinned than fair-skinned individuals (Harris & Dawson-Hughes, 1998;Mithal et al, 2009;Nesby-O'Dell et al, 2002).…”

Section: Genome Wide Association Studiesmentioning

confidence: 91%

“…In the same study no differential methylation was found for CYP27B1 (Zhou et al, ). Beckett et al () described a negative relationship between CYP2R1 / CYP27B1 methylation status and circulating 25(OH)D. Also, the association between serum 25(OH)D and CYP24A1 without correction for vitamin D intake was significant, this suggests that alteration in CYP24A1 methylation happens in response to serum 25(OH)D concentrations, rather than methylation status.…”

Section: Genetic Studies Of Vitamin Dmentioning

confidence: 99%

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Genetic and epigenetic factors influencing vitamin D status

Bahrami

Sadeghnia

Tabatabaeizadeh

et al. 2017

Journal Cellular Physiology

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The global prevalence of vitamin D deficiency appears to be increasing, and the impact of this on human health is important because of the association of vitamin D insufficiency with increased risk of osteoporosis, cardiovascular disease and some cancers. There are few studies on the genetic factors that can influence vitamin D levels. In particular, the data from twin and family-based studies have reported that circulating vitamin D concentrations are partially determined by genetic factors. Moreover, it has been shown that genetic variants (e.g., mutation) and alteration (e.g., deletion, amplification, inversion) in genes involved in the metabolism, catabolism, transport, or binding of vitamin D to it receptor, might affect vitamin D level. However, the underlying genetic determinants of plasma 25-hydroxyvitamin D3 [25(OH)D] concentrations remain to be elucidated. Furthermore, the association between epigenetic modifications such as DNA methylation and vitamin D level has now been reported in several studies. The aim of current review was to provide an overview of the possible value of loci associated to vitamin D metabolism, catabolism, and transport as well epigenetic modification and environmental factors influencing vitamin D status.

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Section: Genome Wide Association Studiesmentioning

confidence: 91%

Section: Genetic Studies Of Vitamin Dmentioning

confidence: 99%

Genetic and epigenetic factors influencing vitamin D status

Bahrami

Sadeghnia

Tabatabaeizadeh

et al. 2017

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…For instance, OMI total ozone column data have been used in several studies to understand the impact of UV exposure on human health (e.g., Beckett et al, 2016;Lucock et al, 2016) similar to the earlier TOMS records (e.g., Boscoe and Schymura, 2006;Chang et al, 2010). A consistent long-term global satellite UV radiation time series is useful for several health-related studies (Langston et al, 2017).…”

Section: Applications Of Omi Data For Health and Air Quality Studiesmentioning

confidence: 99%

The Ozone Monitoring Instrument: overview of 14 years in space

et al. 2018

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Abstract. This overview paper highlights the successes of the Ozone Monitoring Instrument (OMI) on board the Aura satellite spanning a period of nearly 14 years. Data from OMI has been used in a wide range of applications and research resulting in many new findings. Due to its unprecedented spatial resolution, in combination with daily global coverage, OMI plays a unique role in measuring trace gases important for the ozone layer, air quality, and climate change. With the operational very fast delivery (VFD; direct readout) and near real-time (NRT) availability of the data, OMI also plays an important role in the development of operational services in the atmospheric chemistry domain.

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“…The vitamin D receptor (VDR) is a transcription factor belonging to the steroid nuclear receptor superfamily. Its activity is regulated by 1,25‐dihydroxycholecalciferol (1,25(OH)D3; calcitriol), a ligand that is derived from both diet and UV‐mediated skin photosynthesis (Beckett, Duesing, et al, ). Calcitriol liganded VDR action modulates gene expression including that of chromatin modifiers and remodelers, and may influence DNA methylation (Fetahu, Hobaus, & Kallay, ).…”

Section: Introductionmentioning

confidence: 99%