Relationship between metabolic syndrome and osteoarthritis: The Fasa Osteoarthritis Study

Askari, Alireza; Ehrampoush, Elham; Homayounfar, Reza; Arasteh, Peyman; Naghizadeh, Mohammad Mehdi; Yarahmadi, Mohammadreza; Tarbiat, Niloofar; Eghbali, Seyed Sajjad

doi:10.1016/j.dsx.2017.07.002

Cited by 29 publications

(25 citation statements)

References 30 publications

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“…This study did not account for sampling weights in the statistical analysis, even though the study, a nationwide survey, had a stratified, multistage probability sampling design. Contrary to other literature, the small Fasa Osteoarthritis Study showed that the odds ratio between MetS and OA paradoxically increased from 6.8 to 10.9 after adjusting for age, sex, and BMI .…”

Section: Resultscontrasting

confidence: 96%

“…In the Fasa Osteoarthritis Study, the odds ratio paradoxically increased from 6.8 to 10.9 after adjustment for age, sex, and BMI . Despite consistent findings from the literature that age is a strong risk factor for OA, this study showed a paradoxically reduced risk of OA with advanced age .…”

Section: Discussioncontrasting

confidence: 77%

“…In unadjusted analyses from all of these studies, there was a significantly increased risk of OA, and in all, this association diminished greatly and became nonsignificant in all but 1 when analyses were adjusted for BMI . In the Fasa Osteoarthritis Study, the odds ratio paradoxically increased from 6.8 to 10.9 after adjustment for age, sex, and BMI . Despite consistent findings from the literature that age is a strong risk factor for OA, this study showed a paradoxically reduced risk of OA with advanced age .…”

Section: Discussioncontrasting

confidence: 66%

“…For knee OA, 7 studies met our inclusion criteria, of which 2 were cross‐sectional , 1 was a case–control study , and 4 were cohort studies (Table ). Most of the reported effect estimates suggested a null association of MetS with knee OA after adjustment for BMI or weight .…”

Section: Resultsmentioning

confidence: 99%

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What Is the Evidence to Support the Association Between Metabolic Syndrome and Osteoarthritis? A Systematic Review

Felson

2019

Arthritis Care & Research

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Section: Resultscontrasting

confidence: 96%

Section: Discussioncontrasting

confidence: 77%

Section: Discussioncontrasting

confidence: 66%

Section: Resultsmentioning

confidence: 99%

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What Is the Evidence to Support the Association Between Metabolic Syndrome and Osteoarthritis? A Systematic Review

Felson

2019

Arthritis Care & Research

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“…After Puenpatom and Victor (2009) have suggested for the first time that MeS may be associated with OA, multiple studies have documented a relationship between OA and MeS components (Askari et al 2016), which have led to the introduction of the term of metabolic OA (Courties et al 2017). Our findings support the notion that a metabolic factor (or factors), independent from weight, is part of the pathogenesis of OA (Askari et al 2017b).…”

Section: Discussionsupporting

confidence: 80%

The role of adipose tissue secretion in the creation and pain level in osteoarthritis

Askari

Arasteh

Homayounfar

et al. 2020

Endocrine Regulations

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Objectives. With increasing evidence regarding the metabolic basis of osteoarthritis (OA), we studied the relationship between adipose tissue and OA.Methods. This study is part of an OA registry in the eastern part of Fars Province, Iran. Overall, 150 patients with OA and 300 sex matched individuals were selected as a control group. They were compared regarding adipokine concentration (leptin, adiponectin, resistin and visfatin), anthropo-metric indices, the Western Ontario and McMaster universities arthritis index score (WOMAC).Results. All adipokine levels were higher among OA patients (p<0.001). After adjusting for age, sex, and body mass index (BMI), adipokines showed a significant and positive association with OA (B: 14.12, B: 9.92, B: 24.71 and B: 12.29 for leptin, adiponectin, visfatin, and resistin, respectively; p<0.001). Except the adiponectin that had a negative relationship with BMI in the OA group (r=–0.570, p<0.001), other adipokines had positive relationships with BMI (r=0.781, p<0.001; r=0.530, p<0.001; r=0.549, p<0.001 for leptin, visfatin, and resistin, respectively). Only leptin and adiponectin levels were correlated with pain (B: 0.045, –0.079 and p<0.05).Conclusion. The present study shows that aside to the well-known role of mechanical stress in OA pathogenesis (weight load), leptin, adiponectin, visfatin, and resistin, which represent the adi-pose tissue independent on the weight, may play a chemical role in OA pathogenesis. In addition, leptin and adiponectin may be involved in the pain levels among patients with OA.

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Healthy beverage index could decrease odds of metabolic syndrome: A cross‐sectional study

Nouri

Shateri

Rezaei

et al. 2023

Food Science & Nutrition

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Some studies indicated that sugar‐sweetened beverages (SSBs) were related to MetS risk, and others found no relationship between MetS and SSBs. Therefore, the present study aimed to investigate the relationship between healthy beverage index (HBI) and MetS in Iranian adults. This cross‐sectional study was performed on baseline data FASA cohort. Out of 10,127 participants in the FASA cohort study, 8838 participants were included in this study. The National Cholesterol Education Program's Adult Treatment Panel (ATP) III was used for MetS definition. The HBI was calculated by a 125‐item food frequency questionnaire with standard criteria. The association between HBI and MetS and its components was evaluated by univariate regression. Multivariate regression with the backward method was used for adjusting confounders. p < .05 was considered as statistically significant. Compared to the first quartile, it was observed that HBI in the last quartile was significantly related to lower odds of MetS in the multivariate analysis (odds ratio [OR] = 0.72; 95% confidence interval [CI]: 0.60–0.87, p < .001). Also, we observed a significant association between the last quartile of HBI with lower odds of high waist circumference (WC) (OR = 0.55; 95% CI: 0.45–0.67, p < .002). Our findings showed that the higher HBI score reduced MetS odds and WC. Therefore, to reduce the odds of MetS, a healthy pattern of beverage consumption, including drinking water, low‐fat milk, unsweetened tea, and coffee, and reducing the consumption of SSB are recommended. More studies are needed to confirm the findings.

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Relationship between metabolic syndrome and osteoarthritis: The Fasa Osteoarthritis Study

Cited by 29 publications

References 30 publications

What Is the Evidence to Support the Association Between Metabolic Syndrome and Osteoarthritis? A Systematic Review

What Is the Evidence to Support the Association Between Metabolic Syndrome and Osteoarthritis? A Systematic Review

The role of adipose tissue secretion in the creation and pain level in osteoarthritis

Healthy beverage index could decrease odds of metabolic syndrome: A cross‐sectional study

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