Relationship between medication synchronization and antiretroviral adherence

Ghassemi, Emily; Smith, Jennifer; Owens, Laura; Herring, C. T.; Holland, Melissa L.

doi:10.1016/j.japh.2018.05.002

Cited by 4 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Characteristics of included studies are provided in Table C1. Study designs varied, with 1 (4%) randomized controlled trial, 24 3 (11%) quasiexperimental studies, 7,25,26 10 (41%) retrospective cohort studies, [27][28][29][30][31][32][33][34][35][36] 4 (15%) pre-post studies, 37-40 1 (4%) prospective cohort study, 41 1 (4%) cost-benefit analysis, 42 6 (19%) cross-sectional surveys, [43][44][45][46][47][48] and 1 (4%) chart review. 10 Med-sync was provided at different pharmacy settings, such as independent, chain, outpatient, and mail-order pharmacies.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 27 studies, 26 were observational and had moderate to serious bias due to confounding and bias in selection of participants for the study (Table B1). 7,10,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][43][44][45][46][47] All the non-randomized studies had a moderate bias in measurement of outcomes, while two studies had serious bias in measurement of outcomes. 42,48 Confounding was commonly seen as most of the med-sync programs were in conjunction with other programs, such as Medication Therapy Management (MTM), home delivery services, medication reconciliation, adherence packaging, or educational interventions.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 21 studies with clinical outcomes were identified. 7,10,[24][25][26][27][28][29][30][31][32][33][34][35][37][38][39][43][44][45][46] Out of these studies, adherence was the most commonly measured outcome (n = 16). 7,[24][25][26][28][29][30][31][32][33]35,[37][38][39][44][45][46] The study group size ranged from 8 to 126 597.…”

Section: Clinical Outcomesmentioning

confidence: 99%

“…In studies using time as a control, there was an increase in adherence from pre to post-measurement (Table 2). 25,26,33,35,38,39 In studies having a control cohort, the medsync group had a significantly higher adherence to medications compared to the non-med sync group 7,24,26,28,[30][31][32][33]35,37 and less synchronized group (Table 3). 29,45 Other studies using both a cohort and time, showed an increase in adherence from pre to post-measurement (Table 4).…”

Section: Clinical Outcomesmentioning

confidence: 99%

See 3 more Smart Citations

Systematic review of the impact of medication synchronization on healthcare utilization, economic, clinical, and humanistic outcomes

Waghmare

Lindsey

Reed³

et al. 2023

J Am Coll Clin Pharm

View full text Add to dashboard Cite

Medication synchronization (med-sync) or appointment-based medication synchronization (ABMS) programs allow patients to have their chronic medication refills aligned to one pickup day. For patients on multiple chronic medications, it provides a more manageable way of picking up those medications. The objective of the study was to systematically characterize literature describing economic and healthcare utilization, clinical, and humanistic outcomes for patients enrolled in med-sync. A literature search was conducted on PubMed, International Pharmaceutical Abstracts (Ovid), CINAHL (EBSCO), EMBASE (Elsevier), and Cochrane Library. Studies were included if they were conducted at a pharmacy in the United States, between January 2008 and October 2022, and evaluated the impact of med-sync on at least one of the four outcomes of interest (utilization, economic, clinical, and humanistic).The title and abstracts were screened, followed by a full-text review and final data extraction by two researchers. A data extraction template and Cochrane risk of bias tool were used for data collection and quality assessments, respectively. The search resulted in 1617 studies and finally, 27 studies were included in the systematic review. All studies included patients enrolled in either ABMS, med-sync, or in conjunction with other pharmacy services. Across all studies evaluating medication adherence, proportion of days covered (PDC) increased. All studies that administered patient surveys showed a majority of patients were satisfied with their med-sync program. One study showed a reduction in healthcare utilization and costs, while another study indicated no change. Med-sync programs have shown clinical outcomes, specifically to improve adherence in patients taking chronic medications. In terms of humanistic outcomes, patient surveys have shown high rates of satisfaction with med-sync programs. Additional studies are needed to determine if med-sync can lead to improvements in healthcare utilization and cost outcomes.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Clinical Outcomesmentioning

confidence: 99%

Section: Clinical Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

Systematic review of the impact of medication synchronization on healthcare utilization, economic, clinical, and humanistic outcomes

Waghmare

Lindsey

Reed³

et al. 2023

J Am Coll Clin Pharm

View full text Add to dashboard Cite

show abstract

“…For example, Ghassemi and colleagues examined the relationship between enrollment in a medication synchronization program and adherence to antiretroviral therapy (ART) among patients with HIV and found that mean proportion of days covered for patients enrolled in the program was significantly higher than patients not enrolled in the program. 3 This research has the potential to improve health care, as poor adherence to ART may create treatment resistance to that particular antiretroviral agent or group of agents within a given combination therapy regimen. 4 Pharmacists' public health roles were also the focus of practice innovations by community-based pharmacy residents and their preceptors.…”

mentioning

confidence: 99%