Relationship between maternal hemodynamics and plasma natriuretic peptide concentrations during pregnancy complicated by preeclampsia and fetal growth restriction

Giannubilo, Stefano Raffaele; Pasculli, Angela; Tidu, Elisa; Biagini, Alessandra; Boscarato, Virginia; Ciavattini, Andrea

doi:10.1038/jp.2016.264

Cited by 27 publications

(19 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cardiac assessment may also prove useful for guiding antihypertensive therapy and improving outcomes for women with preeclampsia. 79–82 The choice of antihypertensive agent varies between national guidelines despite the fact that drugs of choice have vastly different mechanisms of action and side effect profiles. For instance, labetalol is the first line drug for treatment of pregnancy hypertension in United Kingdom.…”

Section: Putative Roles For Cardiovascular Assessment In the Managemementioning

confidence: 99%

Cardiovascular System in Preeclampsia and Beyond

2019

View full text Add to dashboard Cite

show abstract

Section: Putative Roles For Cardiovascular Assessment In the Managemementioning

confidence: 99%

Cardiovascular System in Preeclampsia and Beyond

2019

View full text Add to dashboard Cite

show abstract

“…NT-proBNP levels are associated with the phase of left ventricular dysfunction; therefore, they reflect the degree of heart failure [19]. It has been determined that NT-proBNP levels are high in women with late-onset preeclampsia [20]. It has been reported that maternal hemodynamic status worsens and NT-proBNP levels are even higher in pregnant women with preeclampsia accompanied by IUGR [21].…”

Section: Discussionmentioning

confidence: 99%

Is ProBNP a New Marker for Predicting Intrauterine Growth Restriction?

Eroğlu¹,

Tonyalı²,

Örgül³

et al. 2021

Z Geburtshilfe Neonatol

View full text Add to dashboard Cite

Purpose To evaluate the usability of first-trimester maternal serum ProBNP levels in the prediction of intrauterine growth restriction (IUGR). Methods In this prospective study, blood samples taken from 500 women who applied to our polyclinic for routine serum aneuploidy screening between the 11–14th gestational weeks were centrifuged. The obtained plasma samples were placed in Eppendorf tubes and stored at −80+°C. For the final analysis, first-trimester maternal serum ProBNP levels of 32 women diagnosed with postpartum IUGR and 32 healthy women randomly selected as the control group were compared. FGR was defined as estimated fetal weight below the 10th percentile for the gestational age. Results The mean ProBNP levels were statistically and significantly higher in the women with intrauterine growth restriction (113.73±94.69 vs. 58.33±47.70 pg/mL, p<0.01). At a cut-off level of 50.93, ProBNP accurately predicted occurrence of IUGR (AUC+= 0.794 (95% confidence interval 0.679–0.910), p+= 0.001) with sensitivity and specificity rates of 78.1 and 69.0%, respectively. Conclusion First-trimester serum ProBNP level was significantly higher in women who developed IUGR compared to healthy controls. First-trimester ProBNP level can be used as a potential marker to predict the development of IUGR in pregnant women.

show abstract

“…Recently a new device has been introduced for the measurement of SV and CO in pregnancy, the UltraSonic Cardiac Output Monitor (USCOM 1A®). This is a non‐invasive hemodynamic monitor that measures cardiovascular values by using a non‐imaging continuous‐wave Doppler transducer placed on the suprasternal notch to determine ascending transaortic blood flow (Figure ).…”

Section: Methods Of Co Measurementmentioning

confidence: 99%

Methods and considerations concerning cardiac output measurement in pregnant women: recommendations of the International Working Group on Maternal Hemodynamics

Bijl

Valensise

Novelli³

et al. 2019

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

Cardiac output (CO), along with blood pressure and vascular resistance, is one of the most important parameters of maternal hemodynamic function. Substantial changes in CO occur in normal pregnancy and in most obstetric complications. With the development of several non‐invasive techniques for the measurement of CO, there is a growing interest in the determination of this parameter in pregnancy. These techniques were initially developed for use in critical‐care settings and were subsequently adopted in obstetrics, often without appropriate validation for use in pregnancy. In this article, methods and devices for the measurement of CO are described and compared, and recommendations are formulated for their use in pregnancy, with the aim of standardizing the assessment of CO and peripheral vascular resistance in clinical practice and research studies on maternal hemodynamics. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.

show abstract

Relationship between maternal hemodynamics and plasma natriuretic peptide concentrations during pregnancy complicated by preeclampsia and fetal growth restriction

Abstract: The elevated NT-proBNP in preeclampsia may reflect ventricular stress and subclinical cardiac dysfunction worsening if FGR is present. This may have implications for the acute management of the preeclampsia and FGR women and for appropriately timed therapeutic interventions later in life.

Cited by 27 publications

References 37 publications

Cardiovascular System in Preeclampsia and Beyond

Cardiovascular System in Preeclampsia and Beyond

Is ProBNP a New Marker for Predicting Intrauterine Growth Restriction?

Methods and considerations concerning cardiac output measurement in pregnant women: recommendations of the International Working Group on Maternal Hemodynamics

Contact Info

Product

Resources

About