Relationship between maternal and fetal lung growth

Faridy, Edmund E.; Bucher, Sherri; Sanii, M.R.

doi:10.1016/0034-5687(88)90004-7

Cited by 5 publications

(1 citation statement)

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“…Since the experimental plan involved estimation of inhaled dose from measurements of ventilation, cohorts were sought that had lungs of the same capacity so that ventilation could be compared directly without correction for lung size. According to data published by Faridy et al (1988), lactating rats have larger lungs than virgin females of the same age due to accelerated lung growth during pregnancy. A significant difference in lung capacity between lactating rats and age-matched virgin females would complicate the correlation of ventilation and tissue dose.…”

Section: Selection Of Lactating and Postlactating Cohorts For Investimentioning

confidence: 84%

Enhanced Pulmonary Inflammatory Response to Ozone During Lactation in Rats: Evaluation of the Influence of Inhaled Dose

Weideman

Chen

Gunnison

1996

Inhalation Toxicology

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We previously demonstrated that rats in a late stage of pregnancy and throughout lactation were more susceptible to pulmonary inflammation induced by exposure to 1 ppm ozone than were age-matched virgin females or rats following lactation. The purpose of the study reported here was to extend the comparison of ozone-induced pulmonary inflammation in lactating and postlactating rats to lower concentrations of ozone and to investigate the hypothesis that the enhanced response demonstrated by lactating rats is attributable to a greater inhaled ozone dose. During pregnancy and lactation the metabolic demands on the female are substantially increased above prepregnancy levels. In response to this metabolic demand, it was shown in this study that the minute volume of air-breathing postpartum rats on day 73 of lactation increased to approximately 150% of that of age-matched postlactating rats with the same lung size. Heightened ventilation in lactating rats was maintained during exposure to 0.3, 0.5, and 1.0 ppm ozone for 6 h, resulting in greater inhaled ozone doses in lactating rats compared to postlactating rats exposed identically. The pulmonary inflammatory response to ozone was assessed in the same rats 18 h after expcsure by comparison of protein concentration and polymorphonuclear cell (PMN) numbers in bronchoalveolar lavage fluid ( B A LF).Both of these parameters were significantly greater m lactating than postlactating rats at 0.3, 0.5, and 1.0ppm ozone. Statistical analysis indicated that most or all of the greater BALF protein in lactating rats could be accounted for by their greater inhaled dose, whereas a significant portion of the enhanced PMN influx in lactating rats remained unexplained by inhaled ozone dose.A recent study from this laboratory demonstrated that acute exposure to 1 ppm ozone induced more severe pulmonary inflammation in late-stage pregnant and lactating rats than in age-matched virgin females or postlactating rats (Gunnison et al., 1992). The experiments described here were undertaken to confirm, at lower ozone concentrations, this earlier observation, and to explore the hypothesis that the enhanced inflammatory response of lactating rats relative to that of postlactating or virgin female rats is attributable to a greater inhaled dose in the lactating rats.

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Section: Selection Of Lactating and Postlactating Cohorts For Investimentioning

confidence: 84%