Relationship between markers of metabolic control and inflammation on severity of periodontal disease in patients with diabetes mellitus

Abstract

The level of glycaemic control as measured by HbA1c emerged as the most consistent risk factor associated with the extent and severity of periodontal disease in this study cohort.

The Relationship between Body Mass Index and Periodontitis in Arab Patients with Type 2 Diabetes Mellitus

“…28 On the contrary, other researchers have demonstrated that glycemic control worsens with the increase in the severity of periodontal disease. 29,30 For example, Lim et al, 29 results depict a positive association between HbA 1c levels and the percentage of sites with PD >5mm. The reason suggested by the authors for poorer periodontal health among patients with poor glycaemic control was that the hyperglycaemic state results in accumulation of advanced glycated end products.…”

Microbiological changes after periodontal therapy in diabetic patients with inadequate metabolic control

“…2,3 Persons with poorly controlled DM also present more severe periodontal disease than do those with well-controlled DM. 4,5 Several mechanisms have been proposed to explain the periodontal etiopathogenesis in patients with DM. 3,6 Significant differences may be present in…”

Lipid Peroxidation Is Associated with the Severity of Periodontal Disease and Local Inflammatory Markers in Patients with Type 2 Diabetes

“…However, it has been reported that periodontitis is one of the first clinical manifestations of diabetes (7) and is recognized as a common complication in diabetic patients (8), particularly in poorly controlled diabetics (9). As an infectious-initiated inflammatory condition, periodontal disease may result in a systemic chronic inflammatory challenge that may have a significant impact on metabolic control in diabetics (10).…”