Relationship between macular ganglion cell complex parameters and visual field parameters after tumor resection in chiasmal compression

Ohkubo, Shinji; Higashide, Tomomi; Takeda, Hisashi; Murotani, Eiji; Hayashi, Yasuhiko; Sugiyama, Kazuhisa

doi:10.1007/s10384-011-0093-4

Cited by 71 publications

(46 citation statements)

References 18 publications

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“…Monteiro et al (9) described hemianopic full-thickness macular thinning in patients with chiasmal compression. Others reported inner retinal thickness (combined RNFL, ganglion cell layer, and inner plexiform layer) thinning with similar results (7,8), and a more recent study showed preferential ganglion cell loss in the nasal hemirentina in patients with pituitary tumors (16). …”

Section: Discussionmentioning

confidence: 52%

“…Some reports indicate that postoperative improvement in VF occurs with preserved RNFL or preserved inner retinal thickness (RNFL, ganglion cell layer, and inner plexiform layer) (7–9,17) An additional report described nasal thinning of the inner retinal layers postoperatively (8). In our study, 93% of eyes had nasal GCC loss postoperatively and 87% experienced VF improvement postoperatively.…”

Section: Discussionmentioning

confidence: 99%

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Ganglion Cell Complex Loss in Chiasmal Compression by Brain Tumors

Tieger

Hedges

et al. 2017

Journal of Neuro-Ophthalmology

128

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Background Patterns of ganglion cell complex (GCC) loss detected by optical coherence tomography provide an objective measure of optic nerve injury. These patterns aid in early diagnosis and localization of chiasmal lesions. Methods Twenty-three patients with chiasmal compression seen between 2010 and 2015 were imaged with the Cirrus high-definition optical coherence tomography macular cube 512 × 128, retinal nerve fiber layer (RNFL) scan protocols and automated (30-2 Humphrey) visual fields (VFs). Age-matched controls were included for comparison. Generalized estimating equations were performed comparing RNFL and GCC thicknesses between patients and their controls. Effect size (d) was calculated to assess the magnitude of difference between patients and controls. The average GCC and RNFL thicknesses also were correlated with VF mean deviation (MD). Pre operative average GCC thickness was correlated to post operative VF MD. Results Patterns of GCC thinning corresponded to VF defects. The average GCC thickness was 67 ± 9 μm in patients and 86 ± 5 μm in controls (P < 0.001). The effect size was the greatest for GCC thickness (d = 2.72). The mean deviation was better correlated with GCC thickness (r2 =0.25) than RNFL thicknesses (r2 =0.15). Postoperatively, VF MD improved in 7 of 8 patients with persistent nasal GCC thinning. Six patients had no VF defect and showed statistically significant loss of GCC compared with controls (P = 0.001). Conclusions Distinct patterns of GCC loss were identified in patients with chiasmal compression. Binasal GCC loss was typical and could be seen with minimal or no detectable VF loss. Thinning of the GCC may be detected before loss of the RNFL in some patients. After decompression, the majority of patients showed improvement in VF despite persistent GCC loss. Patients with less GCC loss before decompression had better postoperative VFs. Therefore, GCC analysis may be an objective method to diagnose and follow patients with chiasmal lesions.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Ganglion Cell Complex Loss in Chiasmal Compression by Brain Tumors

Tieger

Hedges

et al. 2017

Journal of Neuro-Ophthalmology

128

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“…Ohkubo et al [ 55 ] evaluated the relationship between macular GCL and VF parameters in chiasmal compression and the potential for GCL parameters in order to predict the short-term post-surgical VF. Examining the macular GCL was useful for evaluating structural damage in patients with chiasmal compression.…”

Section: Compressive Chiasmal Diseasesmentioning

confidence: 99%

OCT and Compressive Optic Neuropathy

Monteiro

2016

OCT in Central Nervous System Diseases

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Optical coherence tomography (OCT) has provided new and important resources for quantifi cation of retinal neural loss in many different optic nerve diseases including compressive optic neuropathies. As in other optic neuropathies OCT can be useful for diagnosis and follow-up of both optic nerve and chiasmal compressive diseases. Axonal loss can be assessed both through peripapillary retinal nerve fi ber layer measurements as well as using macular thickness measurements, particularly when segmented analysis of different retinal layers are analyzed. By analyzing the amount of axonal loss OCT can also be of help in estimating the possibility of visual improvement in such conditions. In this chapter we discuss the main use of OCT in compressive optic neuropathies including primary optic nerve tumors, extrinsic optic nerve compression by tumors or other orbital lesions and the important group of diseases causing chiasmal compression.

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“…Chiasmal compression from pituitary tumours can result in retrograde degeneration of the ganglion cell axons and thinning of the nasal and temporal retinal nerve fibre layer, [41][42][43][44][45][46][47][48] for which ganglion cell complex analysis can provide more sensitive measurements. 49 Future advances in optical coherence tomography technology will allow further improvements in the detection and quantification of optic nerve dysfunction and subtle changes in nerve head morphology resulting from ocular tumours.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Pituitary macroadenoma: a case report and review

Herse¹

2014

Clinical and Experimental Optometry

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Pituitary adenomas are the most common tumours of the sellar region. They generally have a slow but severe impact on vision due to compression of the optic nerves, optic chiasm and cavernous sinus. This case report reviews the clinical presentation, management and treatment of the major classifications of pituitary adenoma. As Australian optometrists perform over 300,000 visual field assessments per year, it is vital they are aware of this important cause of visual field loss.

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Relationship between macular ganglion cell complex parameters and visual field parameters after tumor resection in chiasmal compression

Abstract: Examining the macular GCC was useful for evaluating structural damage in patients with chiasmal compression. Preoperative GCC parameters, especially FLV, may be useful in predicting visual function following surgical decompression of chiasmal compression.

Cited by 71 publications

References 18 publications

Ganglion Cell Complex Loss in Chiasmal Compression by Brain Tumors

Ganglion Cell Complex Loss in Chiasmal Compression by Brain Tumors

OCT and Compressive Optic Neuropathy

Pituitary macroadenoma: a case report and review

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