Relationship between lung function and blood pressure in Chinese men and women of Beijing and Guangzhou

Abstract

These results suggest a statistically significant, though weak, inverse relationship between lung function and blood pressure in Chinese men and women. This association is largely attributable to age and is present prospectively only in women.

South African and International Reference Values for Lung Function and its Relationship with Blood Pressure in Africans

“…It has been hypothesised that the association can be explained by the confounding effect of age, since lung function decreases and BP increases with age [17]. However, our results remained significant after adjustment for age.…”

“…This is especially notable in patients with chronic obstructive pulmonary disease (COPD) where it has been shown that even moderate reductions in expiratory flow volumes elevate the risk for CVD two-to three-fold [10][11][12][13]. An inverse relationship between lung function and blood pressure has been reported in several studies [14][15][16][17]. Although the mechanism underlying this relationship remains unclear, it has been shown that individuals with reduced lung function have higher levels of C-reactive protein, fibrinogen and other systemic inflammatory markers when compared to those with normal lung function [18,19].…”

Rate of Decline of Forced Vital Capacity Predicts Future Arterial Hypertension

“…These findings were consistent with previous studies that found that inter-individual variation in lung function level in early adulthood to be associated with future development of hypertension. 9,11,12 Our study extended this previous understanding of association between inter-individual differences in lung function and hypertension to include intra-individual change of lung function from peak and hypertension in a generally healthy sample. Lung function deterioration can be seen as an independent factor associated with future hypertension incidence, even for those with low normal lung function.…”

“…Reports have shown inverse cross-sectional associations between lung function measures (especially FVC and FEV1 but not FEV1/FVC) and blood pressure; 5,9,10 however, analyses have been inconsistent. 9,11 On the contrary, cohort studies have shown that lower lung function measures at baseline were consistently associated with higher incidence of subsequent hypertension, 9,11,12 suggesting more rapid blood pressure elevation in persons who initially have lower lung function. This study aimed to assess whether steeper decline in lung function, even within the normal range, is associated with higher incidence of hypertension statistically controlling for level of baseline lung function.…”

Inflammation as Possible Mediator for the Relationship Between Lung and Arterial Function

“…Reduced lung function, as measured by forced expiratory volume in 1 s (FEV 1 ) and forced vital capacity (FVC), is associated with an increased risk for the development of hypertension [1][2][3] and cardiovascular disease (CVD) [4]. Although the association between lung function and CVD is clear, the mechanistic underpinnings of this association remain largely unexplained.…”