Relationship Between Lower Urinary Tract Symptoms and Metabolic Syndrome in a Community-based Elderly Population

Park, Hyoung Keun; Lee, Hae Won; Lee, Kwang Soo; Byun, Seok‐Soo; Jeong, Sung‐Jin; Hong, Sung Kyu; Lee, Sang Eun; Park, Joon Hyuk; Lee, Seok Bum; Kim, Ki Woong

doi:10.1016/j.urology.2008.03.043

Cited by 57 publications

(48 citation statements)

References 15 publications

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“…A weakness to this study was the fact that BPH was determined through medical record coding, without the aid of validated questionnaires or biopsy data. However, similar results were also found by Park et al [ 33 ], who analyzed data from 348 men enrolled in the Korean Longitudinal Study on Health and Aging and found no signifi cant difference in LUTS as measured by the IPSS in men with and without metabolic syndrome as strictly defi ned by the ATPIII.…”

Section: Obesity Obesity-related Disorders and Bph/lutssupporting

confidence: 86%

Lower urinary tract symptoms, benign prostatic hyperplasia, and obesity

Mongiu¹,

McVary

2009

Curr Urol Rep

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Obesity has emerged as a global public health challenge. During the past 20 years, there has been a dramatic increase in obesity in the United States. In 2007, only one state had a prevalence of obesity less than 20%. In this growing epidemic of national concern is an emerging relationship between lower urinary tract symptoms (LUTS), benign prostatic hyperplasia (BPH), and obesity. BPH is the most common neoplastic condition afflicting men and constitutes a major factor impacting the health of the American male. Associations among obesity, physical inactivity, and BPH/LUTS resulting from epidemiological studies have not been explored via clinical trial methodology. A review of the available data appears to support a strong independent relationship between obesity and BPH/LUTS. This review also indicates that gene expression within the prostate varies with prostate size and can be affected by lifestyle modifications. Future studies may lead to office detection of a patient's particular polymorphisms, which may help guide individual treatment and lifestyle modifications that are more likely to succeed.

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Section: Obesity Obesity-related Disorders and Bph/lutssupporting

confidence: 86%

Lower urinary tract symptoms, benign prostatic hyperplasia, and obesity

Mongiu¹,

McVary

2009

Curr Urol Rep

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“…Using a comprehensive literature review, Parsons [24] reported that obesity, DM and physical activity might influence the risk of BPH and LUTS in older men. Although Park et al [25] found no relationship between LUTS and metabolic syndrome in Korean elderly men, their results showed that DM itself was significantly associated with moderate to severe LUTS. Furthermore, the present study showed that metabolic syndrome did not aggravate the severity of LUTS, or emptying function in men with DM and aged <45 years.…”

Section: Discussionmentioning

confidence: 86%

Type 2 diabetes but not metabolic syndrome is associated with an increased risk of lower urinary tract symptoms and erectile dysfunction in men aged <45 years

et al. 2010

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metabolic syndrome with LUTS and ED was also evaluated. RESULTSThe mean ( SD , range) age of the patients was 38.9 (6.1, 20-45) years and the mean duration of diabetes was 2.8 (3.1, 0.5-20) years. Compared with controls, men with T2DM had a significantly mean ( SD ) higher IPSS, of 6.1 (5.8) vs 4.1 (4.6) ( P < 0.001), an increased of odds ratio (95% confidence interval) of having moderate to severe LUTS of 1.78 (1.12-2.84) ( P = 0.01), greater voiding volume of 376 (177) vs 326 (102) mL ( P = 0.04), a worse IIEF-5 score of 17.3 (6.4) vs 20.0 (3.8) ( P < 0.001), an increased of odds ratio of having moderate to severe ED of 3.5 (2.1-5.8) ( P < 0.001) but a similar maximum flow rate and postvoid residual. The IIEF-5 score was negatively correlated with the IPSS ( P < 0.0001, coefficient = − 0.23, 0.35-0.11) and glycosylated haemoglobin ( P = 0.02, coefficient = − 0.14, 0.26-0.01). In all, 156 (69%) patients met the criteria for metabolic syndrome. The mean age, duration of diabetes, glycosylated haemoglobin, IPSS, voided volume, maximum urinary flow rate and IIEF-5 score were similar between patients with and without metabolic syndrome. CONCLUSIONSMen with T2DM and aged < 45 years had more LUTS but a similar bladder emptying function than the controls. ED was highly prevalent and was associated with the severity of LUTS. Metabolic syndrome did not aggravate the severity of LUTS, emptying function or ED in the early stage of DM. OBJECTIVETo investigate the association of type 2 diabetes mellitus (T2DM) and metabolic syndrome with lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) in Taiwanese men aged < 45 years.

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“…While some studies showed a positive association between hyperlipidemia or obesity and LUTS or PV [22,23], others showed no association [24,25]. …”

Section: Discussionmentioning

confidence: 99%

The Relationship between the Clinical Progression of Benign Prostatic Hyperplasia and Metabolic Syndrome: A Prospective Study

Zhou

Yang

et al. 2016

Urol Int

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Objective: To investigate whether metabolic syndrome (MetS) may be associated with the clinical progression of benign prostatic hyperplasia (BPH). Methods: A total of 525 community-dwelling men (aged 45-78) with lower urinary tract symptoms (LUTS) who had complete data at 3-year follow-up were included in this prospective study. International Prostate Symptom Score (IPSS) questionnaire, prostate ultrasonography for prostate volume (PV), maximum urine flow rate (Q_max) and biological parameters were recorded. Participants were divided into a BPH with the MetS group and a BPH without the MetS group, and all received a 3-year follow-up to monitor possible correlations between LUTS/BPH clinical progression and MetS. Results: The results showed that MetS was associated with IPSS, Q_max and PV (p < 0.05) after 3-year follow-up. The mean change of IPSS, PV and Q_max were positively and negatively correlated with time in the BPH with MetS group during the 3-year follow-up. In addition, the BPH clinical progression rate was significantly higher in the BPH with MetS group, compared with the BPH without MetS group (p < 0.05). Diabetes mellitus (DM) and hypertension were related to increased risk of BPH clinical progression. Conclusions: The present results suggest that MetS, in particular, DM and hypertension, may accelerate the clinical progression of BPH in community-dwelling middle-aged and older men.

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Relationship Between Lower Urinary Tract Symptoms and Metabolic Syndrome in a Community-based Elderly Population

Cited by 57 publications

References 15 publications

Lower urinary tract symptoms, benign prostatic hyperplasia, and obesity

Lower urinary tract symptoms, benign prostatic hyperplasia, and obesity

Type 2 diabetes but not metabolic syndrome is associated with an increased risk of lower urinary tract symptoms and erectile dysfunction in men aged <45 years

The Relationship between the Clinical Progression of Benign Prostatic Hyperplasia and Metabolic Syndrome: A Prospective Study

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